Both established at end of 2001

1
GeneCopoeia and FulenGen

• Both established at end of 2001
• FulenGen, Co. Ltd. (Guangzhou, China)
  production facility, sales in China, RD
• GeneCopoeia (Maryland, USA) worldwide
  marketing, sales, and business development, RD
• Combined 85 employees

2
Model of Business Operation
Independent auditing firm, selected and approved
by the Board
Board of Directors

• Venture
• Management
• Administrative
• Production
• RD
• QC/QA
• Sales/marketing
• Export and Import

• Major overseas partner
• Investor/shareholder
• Technologies and product development expertise
• World-wide distribution and new production
  development

• Major partners in China
• Investor/shareholder
• Co-development of products
• Distribution and sales in China

New products
New products
Recruitments of key scientific group leaders and
principal scientists
Collaborative relationships with academic and
business partners
New technology and know-how Licensing and
acquisitions
3
Business Operations and Product lines
20,000 Unique Human Full length ORF Clones.
Selected Groups of ORF Clones from Model Animals
Genomics Products
BioMarker for Diagnostics
Protein Antibody Based Proteomics Products
4
ORFExpress ORF Shuttle Vector and Clones
5
16,000 Human Full Length ORF Clones in Multiple
Expression Systems
Fusion tags
Promoter Host Cell
T7 E. coli
Trac E. coli
GAL1 S. cerevisiae
AcMNPV polyhedrin Insect cells
CMV Mammalian cells
SP6 Translational Enhancer Sequence Cell Free System

• Hisx6
• GFP
• Flag
• GST
• MBP
• His-MBP
• HA
• cMyc
• His-cMyc
• Halo
• Sumo
• AviTag
• His-AviTag

• Adenoviral expression system
• Lentiviral expression system

6
Partial List of Commercial Customers
7
Partial List of Academia Customers
8
Our Partners

• Expertise in biochemical reagent production,
  characterization and quality assessment
• Strong market presence
• Good track record in life science research
  products
• Long time vision about biotech industry in the
  future
• protein, cell line, antibody and biomarker
  business
• Solid finance situation

9
Collaboration by Using OmicsLink Expression
Clones

1. More than 3000 Full ORF Clones for RNAi
   Validation
2. More than 1000 Transcription Factors in
   Lentiviral Vector for Stem Cell Research
3. More than 16,000 Full ORFs for High Density
   Protein Chip Expressed in Cell Free System
4. More than 1000 Full ORFs for Sub-cellular Imaging
   and Trafficking

10
Seamless Cloning Technology
Protein cleavage site
Protein cleavage site
Spacer peptide
Tag
Tag
Protein
Protein
---
---
Protease Cut
Protease Cut
Spacer peptide
Protein
Protein
Allows construction of full length ORF and/or
domain clones that produce proteins without
spacer peptides between Tag and desired proteins
11
Cleavage Efficiency of Peptide-Tag from the
Fusion Protein at 16?C and 25?C by ColdCut
Protease
Tagged-W1269
Tagged-W1269
ColdCut
at 16?C
at 25?C
M
0 3 5 10 20 40

0 3 5 10 20 40

97kD
66kD
43kD
31kD
20kD
12
Cleavage Efficiency of Peptide-Tag from the
Fusion Protein at 4?C by ColdCut Protease
Tagged-W1269)
13
Example of Target Selection for Production of
Protein and Antibody
Highly pancreas specific expression
Expression Level
14
Example of Target Selection for Production of
Protein and Antibody
Highly specific in brain tissues
Expression Level
15
Example of Target Selection for Production of
Protein and Antibody
High expression levels in white blood cells
Expression Level