Agenda:

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XVIII PMT meeting June 5, 2013

• Agenda
• Validation Harmonized Protocol update
• Validation vs pathology
• Hippocampal Label Expansion project update
• - News
• Congress presentations
• Papers

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Validation versus pathology
1 tracer (Greg)
Mony DeLeon 15 AD 5 CTRL at 1.5T postmortem MRI
and quantitative histology (possible additional
AD cases) (Bobinsky paper on 9 AD4 NL sbj
scanned with Philips)
Mayo Clinic AD CTRL MCI dataset with
pathologically confirmed diagnosis (Braaks
stages), but not postmortem hippocampal
measurement
15 Philips 18 GE 13 post-mortem 10 post-m T1
PD
50 antem
Segmentation based on Harmonized Protocol
Analysis based on the information available for
each dataset and vs Bobinskys paper
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de Leon GE PD
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Partial volume??
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de Leon Philips T1
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Hippocampal Label Expansion project update
Subjects 135 Hippocampi 270 MRI tracer tra
cing QC/correction Certification 68/68
1.5 T Masami Complete I-II Complete (67
3T) 30/30 Dominik Complete I-II
Complete 12/12 Rossana Complete I-II
Complete 10/10 Martina Complete I-II
Complete 15/15 Michel Complete I-II
Complete
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Hippocampal Label Expansion project SD update

• SD received all of the certified labels
• Tracers are Masters or platform-Qualified.
  Anyway, exact ICCs across the 5 can be computed
  using the volumes of the Qualification round.
• PLATFORM
• SD has tech support from PAVI, at Université de
  Sherbrooke
• They are looking into file formats for the
  contours
• - SD has scheduled a meeting with the Technical
  Advisory group

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News Subfields
Group composed by Paul Yushkevich, Susan Mueller
and Lei Wang aims to converge hippo-subfields
imagers for protocol harmonization. They asked
for our participation, to tune the protocols and
import harmonizaton methods. We are invited to
present the Hippo Harmonization project a-remoto
to their HS3 meeting, June 21-2
http//hippos3.wordpress.com/
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News Duvernoy
Duvernoy explained some unclear anatomy issues
and approved AC-PC standard orientation Inclusi
on of vestigial tissue Choices of the Delphi
panel Participation as a coauthor
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Congress Presentations

• NEXT HARMONIZATION MEETING JULY 17 H 12-14
• AIC-AAIC (Boston, July 13-18, 2013)
• Training of Naïve Tracers Statistics for
  Certification Platform POSTERS
• - AIC-AAIC developing topics
• Validation phase 1 preliminary data Expansion
  project preliminary data on 1.5T images
• SUBMITTED
• CTAD (San Diego, Nov 3-5, 2011)
• Validation phase 1 preliminary data Expansion
  project preliminary data on 1.5T images
  SUBMITTED

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Papers

1. Survey of protocols (preliminary phase JAD 2011)
2. Operationalization (preliminary phase
   Alzheimers Dementia, published online)
3. Axes check short report (Brescia Team,
   ADJ-D-13-00030, I revision)
4. Master tracers practice and reliability (Brescia
   Team, Sent to coauthors)
5. Development of certification platform (Duchesne
   and coll)
6. Consensual Protocol definition (Brescia Team
   companion paper 1)
7. Validation data (Brescia Team companion paper
   2)
8. Validation vs pathology (TBD)

DONE ONGOING PLANNED
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VALIDATION VS CURRENT PROTOCOLS ASSESSMENT OF
SOURCES OF VARIANCE TRAINING SET DEVELOPMENT
VALIDATION VS PATHOLOGY
GOLD STANDARD
20 naïve tracers
5 master tracers
1 tracer
Local Protocol ADNI scans 2 x 5 Scheltenss
atrophy scores x 2 sides x 2 magnet strengths
(1.5-3T)
Training ADNI scans 10 at 1.5T x 2 sides x 7 SUs
x 2 tracing rounds Total per rater 40 hippos
QUALIFICATION
QUALIFICATION
Harmonized Protocol ADNI scans 2 x 5 Scheltenss
atrophy score x 2 sides x 2 magnet strengths
(1.5-3T) Total per rater 40 hippos
Harmonized Protocol ADNI scans 2 x 5 Scheltenss
atrophy score x 2 sides x 2 magnet strength
(1.5-3T) Total per rater 40 hippos
Harmonized Protocol Pathological datasets Mayo
Clinic and NYU Total about 40 hippos
Assessment of variance due to rater and center
REFERENCE PROBABILISTIC MASKS with 95 C.I.
Best 5 naïve tracers
Assessment of agreement with volume on pathology
or ex vivo MRI and correlation with neuronal
density
Harmonized Protocol ADNI scans 2 sides x 5
Scheltenss atrophy scores x 3 time points
(bl-1y-2y) x 3 scanners ( retracing _at_ bl) x 2
magnet strengths (1.5-3T) Total per rater 240
hippos
Assessment of variance due to side,
trace-retrace, atrophy, time, scanner, rater
TRAINING SET
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GANTT