MEDS 371, Systems Neuroscience

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MEDS 371, Systems Neuroscience Pain System Dr.
D. O. Kim
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dorsal horn of the spinal cord
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CGRP calcitonin gene related
peptide 5-HT serotonin
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VR-1 vanilloid receptor type 1
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Kandel Fig. 24-4
synapse of a C-fiber (C) on the dendrite
(D) of a dorsal-horn neuron. small vesicles
glutamate large vesicles neuropeptides.
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discriminative pain pathways (except face/head)
anterolateral system (ALS) spinothalamic tract
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discriminative pain pathways face/head
trigemino- thalamic tract
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trigeminal pathways
somatosensory cortex
principal trigem. sensory nucleus
trigemino- thalamic tract
trigeminal ganglion
pons
spinal trigem. tract nucleus
medulla
Haines Fig 8-9
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affect
n. the conscious subjective aspect of an
emotion apart from bodily changes. Websters
New Collegiate Dictionary
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Two distinct aspects of the experience of pain
modified from Purves Fig 10-5
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thamaic nuclei
Netter
CM centromedian LD laterodorsal LP
lateroposterior MD mediodorsal VA ventral
anterior VL ventral lateral VPL ventral
posterolateral VPM ventral posteromedial
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Purves Fig. A-12
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affective pain pathways unpleasant quality of
pain
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endogenous opioids enkephalin dynorphin
endorphin
in midbrain periaqueductal gray rost. vent.
medulla spinal cord
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descending control of pain pathways
hypothalamus
Kandel Fig 24-11
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descending control of pain pathways
Purves Fig 10-8B
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placebo effect
a physiological response following the
administration of an inert "remedy"
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referred pain
Kandel Fig. 24-5
Purves
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Methods for Rainville et al., 1997 To immerse a
hand in painfully hot water (47 C) for 75
sec Hypnosis high or low unpleasantness
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Activation of anterior cingulate cortex (ACC)
by pain
PET imaging of human brains
Rainville et al 1997