FORMATS OF NIH APPLICATIONS

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FORMATS OF NIH APPLICATIONS
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Acknowledgment

• James S. Panagis, MD, MPH
• Director, Orthopaedics Program
• NIAMS, NIH, DHHS
• 6701 Democracy Boulevard, 800Bethesda, MD
  20892(P) 301-594-5055(F) 301-480-4543jp149d_at_nih
  .gov

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NIH

• 27 Institutes and Centers
• Budgets (FY 2005)
• NIH 28 Billion
• NIAMS 511 Million
• gt 70,000 applications in FY 2004

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Types of Applications

• Unsolicited
• Solicited
• Program Announcement (PA)
• Request for Applications (RFA)
• Request for Contracts (RFC)

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NIH Receipt, Review Award Cycles
Cycle I Cycle II Cycle III
All New Competing Applications February 1 June 1 October 1
Revised Proposals March 1 July 1 November 1
Scientific Review June-July Oct-Nov Feb-March
Advisory Council Sep-Oct Jan-Feb May-June
Earliest Start December April July
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Funding Mechanisms

• Training F 31, 32, 33
• Career Development K 01, 02, 08, 22, 23, 24, 25
• P 01
• P 30, 50, 60
• Research R 01, 03, 15, 21, 37
• R 41, 42, 43, 44
• T 32
• U 01

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Career Timeline NIH Mechanisms

• Medical School
• Residency
• Fellowship
• Junior Faculty
• Career

• T32
• T32
• F32
• K01, K08, K22, K23, R03, R21
• R01, R21, K24

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What is the Right Mechanism?

• Your training experience
• What you need
• What you would like to do (time amount)

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Career Development Award

• K Awards

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Mentored Research Scientist Development Award

• K01
• http//grants.nih.gov/grants/guide/pa-files/PA-00-
  019.html

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K01

• Purpose is to develop outstanding scientists
• 3 5 yrs of supervised research experience
• 75 effort
• Ineligible if prior R01, R29, K(01,07,23),
  P(01,50)
• Salary Salary determined by I/C
• NIAMS75,000)

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K01

• Research Dev. Support i.e., tuition, fees
  research support. Amount varies (NIAMS
  20,000)
• Facilities Admin costs Fixed at 8
• Mentor should have independent research support
  (mentor is not salaried)
• Standard receipt dates

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Mentored Clinician Scientist Development Award

• K08
• http//grants.nih.gov/grants/guide/pa-files/PA-00-
  003.html

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K08

• Purpose is to develop clinical research
  scientists
• Similar format/regulations to K01
• 52.3 success rate

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NIAMS Career Transition Award

• K22
• http//www.niams.nih.gov/rtac/funding/grants/pa/pa
  r_02_056.pdf

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K22

• Provides training within a NIAMS intramural lab
  followed by support in an extramural institution
• Ineligible if prior R01, R29, SBIR/STTR, P01,
  P50, K08
• Provides up to 150,000/YR for all years

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K22

• Intramural (Phase I) Salary based upon training
  experience.
• Extramural (Phase II) Salary up to 75,000.
  Can be supplemented. 75 effort. Up to 75,000
  for research supplies.
• F A 8
• Standard receipt dates
• 40.2 success rate

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Mentored Patient-Oriented Research Career
Development Award

• K23
• http//grants.nih.gov/grants/guide/pa-files/PA-00-
  004.html

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K23

• Purpose is to develop clinical researchers
• 3 5 yrs of support 75 effort
• Same eligibility as the other Ks
• Salary Varies by I/C. May be supplemented
  (NIAMS 75,000)
• Res. Development Support Up to 25,000
• F A 8

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K23

• Mentors should have independent research support
• Can not be salaried.
• Standard receipt dates
• 46.6 success rate

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Mentored Quantitative Research Career Development
Award

• K25
• http//grants.nih.gov/grants/guide/pa-files/PA-02-
  127.html

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K25

• Purpose is to foster interdisciplinary
  collaboration in biomedical research by
  supporting career development experiences for
  scientists with quantitative and engineering
  backgrounds
• 3-5 YRS of support
• 75 effort
• Similar format/regulations as other Ks

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NIAMS Small Grant Award for New Investigators

• R03
• http//www.niams.nih.gov/rtac/funding/grants/pa/pa
  r_04_002.pdf

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R03

• Funding for pilot/preliminary data
• Ineligible if previous/current large mechanism
  support, or NIAMS R21
• Receipt dates 2/24/05, 6/24/05, 10/24/05
• Up to 3 YRS of support
• Up to 50,000 direct costs/YR
• Limited to 2 small grant awards/career
• Lower success rate due to of apps

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Exploratory/Developmental Research Grant

• R21

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R21

• Appropriate for early stages of research that are
  high risk because of possible failure, but if
  successful, may be of significant benefit
• 2 YRS of support 275,000 split over the 2 yrs

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R21 Program Announcements

• PA-03-058 Exploratory/Developmental (R21)
  Bioengineering Research Grant (EBRG)
  http//www.niams.nih.gov/rtac/funding/grants/pa/pa
  _03_058.pdf
• PA-03-107 NIH Exploratory/Developmental
  Research Grant Award (R21) http//www.niams.nih.go
  v/rtac/funding/grants/pa/pa_03_107.pdf

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Shorter Duration R01

• Prove feasibility, setting stage for what to
  follow in a competing continuation
• Suggest 3 years
• Avoids being overly ambitious in an R03, or if
  limited preliminary data, high risk for a
  longer duration R01

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NIH Loan Repayment Program for Clinical
Researchers

• Purpose To recruit retain clinical
  investigators
• Re-pays up to 35,000/YR of educational loan
  expenses for each YR of obligated service
• Also pays 39 of loan repayment to IRS
• Must agree to engage in clinical research a
  minimum of 2 years
• http//www.lrp.nih.gov

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Tips

• Contact NIH Program Officer (PO)
• Read application instructions carefully
• Focus on perfecting the abstract specific aims
• Communicate clearly thoroughly
• Allow time for a thorough editing proofreading
• Have knowledgeable colleagues review application
• Send in supplemental progress materials, papers
• Speak with NIH PO post-review
• Be prepared to revise in response to critique

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BE PERSISTENT
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Resources

• NIAMS Homepage http//www.niams.nih.gov
• NIH Grants Page http//grants1.nih.gov/grants/oer
  .htm
• Welcome Wagon http//grants1.nih.gov/grants/fun
  ding/welcomewagon.htm
• Getting Started at the NIH http//grants1.nih.g
  ov/grants/useful_links.htm
• Grant Writing Tips http//grants1.nih.gov/grant
  s/grant_tips.htm

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Resources Tutorials

• How to Write a Grant Application
  www.niaid.nih.gov/ncn/grants/write/write.pdf
• Advice on Research Training Career Awards
  www.niaid.nih.gov/ncn/grants/advice/advice.pdf
• How to Write an Application Involving Animals
  www.niaid.nih.gov/ncn/clinical/researchanimals/tut
  orial/researchanimals.pdf
• How to Write a Human Subjects Application
  www.niaid.nih.gov/ncn/clinical/humansubjects/human
  subjects.pdf
• Annotated R01 Grant Application
  www.niaid.nih.gov/ncn/grants/app/default.htm