????????-?????? ???????

1
????????-?????? ??????? ??????????? ???????1.
???????? ??????????????-????????? ??????? ???????
????????????(??????????? ????????? ?????????)2.
??????? ???????? ??????????? ?
???????????-????????????? ?????????
2
3. ???????(????????? ??????)-???????????,
???????, ???? ???????-???????????????
?????????4. ??????????-??? 160/95(??????
2)-?????????????????
3
ß-??????? (??????????? ?? -??????????????
?????????)
ß

• 1958 ?., ??????? ?? ??????????? ??
  Dichloroisoprotenerol.

Isoprenaline
4
?????????????????????
????? ?? beta-??????????????
????????? ????????????
??????????? ???????? ?????????
?? ???????? ?? ?????????
??????? ?? ????????? ???????????? ???????? ????
??????? ?? ?????????
???????? ?????????????? ????????
5
??? ????? ?? ??????????
6
???????????? ? ????????? Propranolol
1-(??????????????)-3-(1-??????????)-2-????????
???????????
Ph Eur
(2RS)-1-(1-methylethyl)amino-3-(naphthalen-1-ylo
xy)propan-2-ol hydrochloride
7
??????????
Naphthoxylactic Acid
8
(No Transcript)
9
??????????1962 US Pat.
10
(No Transcript)
11
4-3-(??????????????)-2-????????-?????????????
Ph Eur
(2RS)-1-(1H-indol-4-yloxy)-3-(1-methylethyl)amin
opropan-2-ol
12
Oxprenolol Hydrochloride
3-(??????????????)-1-2-(????????)-???????- 2-???
????? ???????????
(2RS)-1-(1-methylethyl)amino-3-2-(prop-2-enylox
y)phenoxypropan-2-ol hydrochloride
Ph Eur
13
?????????? ?? ?????????
14
(No Transcript)
15
(No Transcript)
16
Metoprolol Succinate
Ph Eur
Bis(2RS)-1-4-(2-methoxyethyl)phenoxy-3- (1-met
hylethyl)aminopropan-2-ol butanedioate
1-??????????????-3-(4-???????????)???????-2-??????
??
Metoprolol Tartrate
Ph Eur
Bis(2RS)-1-4-(2-methoxyethyl)phenoxy-3- (1-met
hylethyl)aminopropan-2-ol (2R,3R)-2,3-dihydroxyb
utanedioate.
17
4-3-(??????????????)-2-????????????????-????????
??????
Ph Eur
2-4-(2RS)-2-hydroxy-3-(1-methylethyl)aminoprop
oxyphenylacetamide
18
N-3-??????-4-2-????????-3- (1-?????-????)?????
?????????????????????? ???????????
Acebutolol Hydrochloride
Ph Eur
N-3-Acetyl-4-(2RS)-2-hydroxy-3- (1-methylethyl)
aminopropoxyphenylbutanamide hydrochloride
19
???????????
20
Bisoprolol
1-4-2-(1-???????????)??????????????????- 3-
(1-?????????)?????-2-???????? ???????
21
?????? beta1-c???????????

• Propranolol 0
• Metoprorol 1,1
• Atenolol 1,7
• Bisoprolol 2,5

22
??? ?????????
23

• ß-??????? ? ?????????? ??????????????
  ?????????
• Labetalol

Antihypertensive
5-1-????????-2-(1-?????-3-???????????)?????????
??????????? ???????????
Labetalol Hydrochloride
Ph Eur
alpha-and beta-adrenoceptor antagonist
2-hydroxy-5-1-hydroxy-2-(1-methyl-3- phenylpropy
l)aminoethylbenzamide hydrochloride