PowerPoint-presentatie

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Mx Practical Monday afternoon 2 Group analysis 6
Group analysis Trivariate analysis
Based on the paper Marian Beekman, Bastiaan T.
Heijmans, Nicholas G. Martin, Nancy L. Pedersen,
John B. Whitfield, Ulf DeFaire, G. Caroline M.
van Baal, Harold Snieder, George P. Vogler,
P.Eline Slagboom, and Dorret I. Boomsma (2002).
Heritability of Apolipoprotein and Lipid Level in
Three Countries. Twin Research, 5(2) 87-97.
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
2
Monday Practical

• get scripts and data F\meike\
• - 2 group analysis
• - 6 group analysis
• - trivariate analysis
• Practical in two ways
• rookies listen to CAROLINE!!!
• advanced students work independently

The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
3
Description of the data
Variables NIH_ID identification
number POPUL/COUNTRY population (1 Dutch
younger population 2 Dutch older population 3
Australian population 4 Swedish
population) ZYGOT6 zygosity (1 MZM 2 DZM 3
MZF 4 DZF 5 DOS m-f 6 DOS f-m) REAR how
are the twins reared (relevant for Swedish
population only 1 reared apart 2 reared
together AGE age at time of measurement (years)
SEXA sex oldest (expressed by
A) LDLLNA LDL oldest (Ln-transformed) APOBLNA
ApoB oldest (Ln transformed) APOELNA ApoE
oldest (Ln transformed) SEXB sex
youngest (expressed by B) LDLLNB LDL
youngest (Ln transformed) APOBLNB ApoB
youngest (Ln transformed) APOELNB ApoE
youngest (Ln transformed)
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
4
Twin correlations LDL
MZM .86 DZM .26 MZF .77 DZF .53 DOS-mf .
73 DOS-fm .07
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
5
Advanced students
F\meike\6 group analysis - 6
group_practical.mx - Fix the script, run the job
and dont forget to look at your
output! - reduce model to models without sex
differences and/or AE, CE and E models -
change this script to a trivariate
cholesky and calculate genetic
correlations
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
6
The Univariate Model
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
7
Go to Mx
F\meike\2 group analysis open script 2
group.mx
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
8
The Univariate Model
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
9
The Trivariate Model
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
10
The Trivariate Model
a31
a32
a21
a33
a11
a22
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003
11
The Trivariate Model
a11 0 0 a11 a21 a31 a21 a22 0 0 a22 a32 a31 a3
2 a33 0 0 a33


a11 a11 a11 a21 a11 a31 a21 a11 a21 a21
a22 a22 a21 a31 a22 a32 a31 a11 a31 a21 a32
a22 a31 a31 a32 a32 a33 a33
The Sixteenth
International Workshop on Methodology of Twin and
Family Studies, Boulder, CO, March 2003