ZINC 96

1
????? ?????? ??????? ????? ??????? ?? ??????
??? ???????
?"? ????? ???????
???? ????? ???????? ????????? ????? ??????
?????? ???????? ?"? ??? ???? -??? ???"? ??????
?????? ??????? ??????? ????
2
? ? ? ? ????? ?????? ??????? ?????? ???
???????
?????? ???? ??? ???? ?? ?????? ????????
????????????
22-23 ?????? 2003 - ???? ???? ??????????????, ??
????
3
EXPANDING HEALTH FRONTIERS IN THE 21ST
CENTURY

• HOW CAN WE PROMOTE HEALTH FOR PEOPLE
• IN ALL AGE GROUPS

PREVENTIVE MEDICINE
4
EXPANDING HEALTH FRONTIERS IN THE 21ST
CENTURY

• HOW CAN WE PROMOTE HEALTH FOR PEOPLE IN
  ALL AGE GROUPS

IN THE PRESENCE OF THE GERIATRIC BOOM
CATASTROPHE?
5
GERIATRIC BOOM CATASTROPHE
B U R D E N

• THE SUM OF
  THE EXPONENTIALLY
  ACCUMULATING MEDICAL, ECONOMIC AND SOCIAL
  AGE - RELATED PROBLEMS

GARFINKEL 1997
6
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
THROUGHOUT HISTORY, THE MAJOR
FACTORS AFFECTING HEALTH OF THE GENERAL
POPULATION

IMPROVED HYGIENE SANITATION

MALNUTRITION
ENVIRONMENTAL
INFECTIONS EPIDEMICS
2000
1900
1800
B.C.
7
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
IN THE 21st. CENTURY , THE MAJOR FACTOR
AFFECTING HEALTH OF THE GENERAL
POPULATION

21st. CENTURY
2000
1900
1800
A G I N G !!!
IS BIOLOGICAL -
B.C.
8
DEFINITION OF AGING
ANY TIME - DEPENDENT CHANGES
WHICH OCCUR AFTER MATURITY OF
SIZE, FORM AND FUNCTION IS REACHED.

(Rockstein , 1977)
THE PROGRESSIVE PHYSIOLOGIC, CELLULAR,
BIOSOCIAL, CULTURAL AND PSYCHOLOGICAL
CHANGES THAT TAKE PLACE AT LEAST FROM
THE MOMENT OF CONCEPTION UNTIL DEATH.

(Young, 1983)
9
THEORIES OF AGING
AT THE PRESENT TIME, IT IS IMPOSSIBLE
TO TELL WHETHER ALL THE PIECES OF THE
AGING PUZZLLE ARE AT HAND...

UNTIL A GENERAL THEORY APPEARES
THAT WILL UNIFY THE
FACTS..
NO ONE CAN OFFER MORE THAN AN
INFORMED GUESS AS TO WHERE THE KEY FACTS
LIE.
(G.B. Moment 1982)
10
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
The BIOLOGY of AGING - GENETICS
Has NOT Changed Much Throughout History A Fixed,
Species Specific Maximal Life Span

DEMOGRAPHIC Changes -
11
SURVIVAL CURVES
Survival
25
75
50
100
12
SURVIVAL CURVES
survival
21ST. CENTURY
25
75
50
100
13
SURVIVAL CURVES
SURVIVAL
75
50
25
100
14
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
The BIOLOGY of AGING GENETICS
Has NOT Changed Much Throughout History A Fixed,
Species Specific Maximal Life Span

• A Rapid Increase in the Average Life Span
• More People Reach Advanced Age
• Population Aging Elders Birth rate

DEMOGRAPHIC - Changes
AGING DISEASES -
15
DEFINITION OF AGING
Aging is the Process that Converts
Fit Adults into Frailer Adults
With a Progressive Increased Risk
of Illness, Injury and Death.
Richard A. Miller J Gerontol,
Biological Sciences 1999 54A B297 - B307.
16
DISEASES OR DISFUNCTIONS ASSOCIATED
WITH AGING

• ATHEROSCLEROSIS HEART ATTACK, STROKE, PVD
  
• CANCER MOST TYPES
• CATARACT SENILE TYPE
• DEMENTIA SENILE,
  ALZHEIMER
• DEPRESSION MONOPOLAR
• DIABETES MELLITUS TYPE II
• GLAUCOMA
• HYPOTHERMIA INCREASED
  SUSCEPTIBILITY

17
DISEASES OR DISFUNCTIONS ASSOCIATED
WITH AGING

• IMPAIRED HEALING WOUND AND FRACTURE
• IMPAIRED IMMUNITY CELLULAR HUMORAL
• I N F E C T I O N S
  INCREASED SUSCEPTIBILITY
• OSTEOPOROSIS OSTEOARTHROSIS

PARKINSONS DISEASE PRESBYOPIA
PRESBYACUSIS PROSTATIC HYPERTROPHY SENILE
MACULAR DEGENERATION - AMD URINARY INCONTINENCE
18
THE BAD SIDE OF AGINGAGE - RELATED
DISEASES DISFUNCTIONS
ATHEROSCLEROSIS
C A N C E R
D E M E N T I A
D E P R E S S I O N

• IMPAIRED IMMUNITY
  INCONTINENCE
• OSTEOPOROSIS OSTEOARTHROSIS

DIABETES MELLITUS CATARACT,
GLAUCOMA, AMD, RESBYOPIA,
HEARING LOSS, PRESBYACUSIS PROSTATIC
HYPERTROPHY, PARKINSONS DISEASE
19
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
The BIOLOGY of AGING - GENETICS
Has NOT Changed Much Throughout History A Fixed,
Species Specific Maximal Life Span

• A Rapid Increase in the Average Life Span
• More People Reach Advanced Age
• Population Aging Elders gt Birth rate

DEMOGRAPHIC - Changes
AGING DISEASES -
Increased Rate Complexity of
Age-related,
Chronic, Debilitating Diseases
MEDIAL CARE Changes -
20
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
MEDIAL CARE CHANGES
Better Treatment for Acute Diseases
Increased Need for Chronic Palliative Care
21
PALLIATIVE CARE

• DEFINITION
• The Active Total Care of Patients
• Whose Disease is Not Responsive
• to Curative Treatment
• 
  
  

(W.H.O.)
22
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
The BIOLOGY of AGING - GENETICS
Has NOT Changed Much Throughout History A Fixed,
Species Specific Maximal Life Span

• A Rapid Increase in the Average Life Span
• More People Reach Advanced Age
• Population Aging Elders gt Birth rate

DEMOGRAPHIC - Changes
AGING DISEASES -
Increased Rate Complexity of
Age-related,
Chronic, Debilitating Diseases
Better Treatment for Acute Diseases Increased
Need for Chronic Palliative Care
MEDIAL CARE Changes -
POPULATION BALANCE - Changes
23
POPULATION BALANCE
Garfinkel D., 1997
ANCIENT ROME
C H I L D R E N
POPULATION
PRODUCTIVE
25
75
50
100
24
POPULATION BALANCE
Garfinkel D., 1997
CHILDREN
2 0 0 0
POPULATION
PRODUCTIVE
25
75
50
100
25
GERIATRIC BOOM CATASTROPHE
Garfinkel D., 1997
CHILDREN
PRODUCTIVE
21 st. CENTURY
POPULATION
DEPENDENT
25
75
50
100
26
1995 gtgt 2020
MURRAY LOPEZ, THE LANCET 1997 MAY 3, 10, 17, 24
27
GLOBAL HEALTH CARE - GOAL
GERIATRIC
DEATH

DEATH
VERY SICK
PALLIATIVE
SICK
CURATIVE
PREVENTION
HEALTHY

HEALTH PROMOTION
28
GLOBAL HEALTH IN THE ELDERLY
PALLIATIVE MEDICINE
VERY SICK

CURATIVE MEDICINE
SICK
AGE
PREVENTION HEALTH PROMOTION
HEALTHY
29
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
Four Living Generations in Many Families. A
Rapidly Distorted Balance Between the Sick,
Debilitated, Non-productive, Poor Elders - and
the Young, Healthy, Productive Population that
has to Bear the Burden.
POPULATION BALANCE SOCIAL Change
ECONOMIC -
30
DISABILITY ADJUSTED LIFE YEARS
LEADING CAUSES IN 2020 (Excluding Cancer)

• Ischemic Heart Disease
• Unipolar Major Depression
• Road-Traffic Accidents

• Cerebrovascular Disease
• Chronic Obstructive Lung Disease
• Lower Respiratory Infections
• Tuberculosis
• War Injuries
• Diarrheal Diseases

2020
31
GLOBAL BURDEN OF CANCER

• 60 of all Cancers Occur in the Population
  Over the age of 65......
• The Absolute Number of Older Cancer
  Patients Will Only Increase in the Next
  Three Decades, and

WE ARE ILL EQIPPED FOR THIS
INTELLECTUALLY,
EMOTIONALLY
ECONOMICALLY
WB Ershler, Editor, J Gerontol 1997
32
GLOBAL BURDEN OF CANCER

• Large Increases in Absolute Numbers of
  Cancer Patients ... in the Next Century
  are Already Programmed Due to the

Oncological Time - Bomb
of the Ageing Population This has
Important Implications for Public Health.

Peter Boyle, The Lancet, May 1997
33
GLOBAL BURDEN OF CANCER

• NEW CASES OF CANCER WORLDWIDE
• ( in millions )
• 1975 5.9
• 1980 6.4
• 1985 7.6
• 1990 8.4
• 2000 10.3
  (estimated)

34
Number of Hip Fractures Annually
ESTIMATED
No. (x 1000)
?
USA
UK
1980
2000
2050
35
Number of Patients with Dementia
ESTIMATED
?
No. x 106
USA
USA
UK
UK
1980
2000
2050
36
GLOBAL BURDEN OF DISEASE
"?????? ??????? ????..." ???? ??? ???? ???? ????
??? ??????? ????? ?????? ??????? ???????? ??
????? ??????? ???????. ?????? ?????? "???"
????????? ????? ??????? ????? ?? ??? ????? ????
?? ????? ???? - ?????, ????? ??????.
???? ??? ?????? ?????? ?????? ???? 65 - 74 ????
?????? ???????? ?????.
??????? ?????? ??? ???? (ADL) ????? ????? ?????
??????? ???? ??? ?????? ???? ????? ??? ??????
?????? ????? ?????? ?????. ?????? ?????? ??????
???????? ?????? ?? ????? ?????? ????, ?????? ????
??? ???? ?????... ???? ???? ????? ???? ??????,
???? ?? ????? ??????? ????? ??????? ????.
?????, ???? ?????? ????"? ???? ???? ????????
(NURSING HOMES) ???? 1985 ??? 1.1 ??????. ?????
????? ???? 2000 ????? ????? ???? 2050 ? - 5.5
?????!
37
(No Transcript)
38
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
Four Living Generations in Many Families. A
Rapidly Distorted Balance Between the Sick,
Debilitated, Non-productive, Poor Elders- and
the Young, Healthy, Productive Population that
has to Bear the Burden.
POPULATION BALANCE - SOCIAL Change
Expenditures for the Elderly and Disabled are
Growing Rapidly in an Alarming Rate Social
Security Resources Health Insurance may NOT
Suffice
ECONOMIC -

• ETHICAL LEGAL -
• Restrains

39
GLOBAL BURDEN OF DISEASE
COST
HUMANITY
MEDICINE
LAWS
ETHICS
40
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
POINTS FOR CONSIDERATION
Four Living Generations in Many Families. A
Rapidly Distorted Balance Between the Sick,
Debilitated, Non-productive, Poor Elders- and
the Young, Healthy, Productive Population that
has to Bear the Burden.
POPULATION BALANCE - SOCIAL Change
Expenditures for the Elderly and Disabled are
Growing Rapidly in an Alarming Rate Social
Security Resources Health Insurance may NOT
Suffice
ECONOMIC -

• ETHICAL LEGAL
• Restrains

• Do Not Allow us to Denote Specific Age-related
• Medical Conditions that we do Not Treat/Support
• Our Children may have to Decide Whether
• to Optimally Care for Their Parents OR
• Invest in Their Childrens
  Future .

41
???? ??????
???? ?????? ?????? ??????? ?? ???? ????
??? ????????? ??????? ??????? ????
????? ????? ????, ?????,????? ??????
???????? ?????? ?????? ?????,??????????,??
???,?????, ?????? ??????, ????? ???????,
????? ??????

• ????? ?????? ??????? ?????? ????? ?????
• ??????? ?/?? ????? ?????? ??????? ????

42
I N H I B I T I O N OF GERIATRIC BOOM
Garfinkel D., 1997
CHILDREN
POPULATION
PRODUCTIVE
DEPENDENT
75
50
25
100
43
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
I WANT TO DIE YOUNG..

• AS LATE IN LIFE AS POSSIBLE !

44
HEALTH PROMOTION IN A RAPIDLY
CHANGING WORLD
WHO IS GOING TO DO IT ???
TO WHOM ?? WHEN TO START ? HOW ?
EMBRYO CHILD YOUNG MIDDLE AGE
ELDERLY EMBRYO CHILD
YOUNG MIDDLE AGE ELDERLY
EMBRYO CHILD
YOUNG MIDDLE AGE ELDERLY


EMBRYO CHILD
YOUNG MIDDLE AGE ELDERLY

EMBRYO
CHILD YOUNG MIDDLE AGE
G E R I A T R I C I A N S
F A M I L Y P H Y S I C I A N S
P E D I A T R I C I A N S
PREVENTION SHOULD START AS EARLY AS POSSIBLE
45

ANTI AGING EXPERTS" ....
YES, TAKE THIS PILL AND YOU WILL BE YOUNG FOREVER
!!! (HA, HA, HA)
46
ANTI AGING MEDICINECHARACTERISTICS
THERE CANT BE TWO KINDS OF MEDICINE -
CONVENTIONAL AND ALTERNATIVE

THERE IS ONLY MEDICINE THAT HAS BEEN
ADEQUATELY TESTED AND MEDICINE
THAT HAS NOT, MEDICINE THAT WORKS AND
MEDICINE THAT MAY OR MAY NOT WORK
New Eng J Med 1998
47
ANTI AGING MEDICINECHARACTERISTICS
ONCE TESTED, IT NO LONGER MATTERS WHETHER
IT WAS CONSIDERED ALTERNATIVE AT THE
OUTSET. IF FOUND TO BE REASONABLY SAFE
AND EFFECTIVE, IT WILL BE ACCEPTED.

• BUT ASSERTIONS, SPECULATION AND TESTIMONIALS
• DO NOT SUBSTITUTE FOR EVIDENCE.

New Eng J Med 1998
48
ANTI AGING MEDICINECHARACTERISTICS
THE MOST DISTURBING ASPECT OF THE
ANTI-AGING MEDICINE MOVEMENT IS ITS CLEAR
CUT COMMERCIALITY

• MANY OF THE ANTI-AGING PRODUCTS
• MIGHT EVEN POSE PHYSICAL AND ECONOMIC HARM
• SENIORS ARE PARTICULARLY SUSCEPTIBLE
  RISK OF POSSIBLY DANGEROUS DRUG
  INTERACTIONS
• MANY PRODUCTS WERE FOUND NOT TO MEET
  CRITERIA GIVEN ON THE LABEL
• ONE IN 10 HERBAL PRODUCTS MAY BE
  CONTAMINATED BY PESTICIDES AND HEAVY METALS

United States General Accounting Office (GAO),
Report Sept. 2001
49
ANTI AGING MEDICINECHARACTERISTICS

• FALSE HOPES OF REJUVENATION
• BY ALTERNATIVE MEDICINE AND
• ANTI - AGING PRODUCTS
• DELAYS APPROPRIATE
• PROFESSIONAL THERAPY

United States General Accounting Office (GAO),
Report Sept. 2001
50

THE "ANTI AGING EXPERT" VS. THE FAMILY
PHYSICIAN
51

THE "ANTI AGING EXPERT" VS. THE FAMILY
PHYSICIAN
MAKE MONEY ! PUBLICITY, MARKETING
EVIDENCE BASED GOOD PRACTICE MEDICINE
52
ANTI AGING EXPERTS" CHARACTERISTICS
UNLIKE THE FAMILY PHYSICIAN

• USE AGGRESSIVE METHODS OF
• MARKETING TO PROMOTE
• THEIR CLINICS
• (MEDIA, FAMOUS ACTORS
• CELERITIES,
  Etc.)

53
ANTI AGING EXPERTS" CHARACTERISTICS
CLAIM TO SOLVE A PROBLEM THAT IS
REALLY ESSENTIAL - INHIBITION OF AGING
THIS GOAL IS ACTUALLY INDISTIGUISHABLE FROM
CONVENTIONAL HEALTH PROMOTION OFFERED BY THE
FAMILY PHYSICIAN
CLAIM TO BE EXPERTS IN THE FIELD AND
THEREFORE SUPERIOR TO THE FAMILY
PHYSICIAN THOUGH, IN MANY CASES ARE NOT
SPECIALISTS IN ANY MEDICAL FIELD
54

ANTI AGING EXPERTS" CHARACTERISTICS

• PERFORM ( SEND TO THE U.S.) MANY
• EXPENSIVE LABORATORY TESTS WITH
• ATTRACTIVE NAMES ALL MINERALS
• VITAMINS AND ANTI OXIDANTS

• FOR MANY OF THESE TESTS,
• NOTHING PRACTICAL CAN BE DONE
• WITH THE
  RESULTS !

55
ANTI AGING EXPERTS" CHARACTERISTICS
UNLIKE THE FAMILY PHYSICIAN

• GIVE A VERY CLEAR PROMISE COME TO ME,
• ILL MAKE YOU YOUNGER AND HEALTHIER !

MIX CONVENTIONAL ACCEPTED REMEDIES
WITH UNPROVEN BUT VERY POPULAR MEANS WITH
APPEALING NAMES (eg. ANCIENT, ORIENTAL,
REJUVENILE, YOUTH INJECTIONS etc)
56
ANTI AGING EXPERTS" CHARACTERISTICS

• FIGHT SCIENTIFIC CRITICS USING POPULAR,
• PSYCHOLOGICALLY APPEALING MEANS
• MANY GREAT INVENTIONS HAVE NOT BEEN PROVEN
• OR ACCEPTED INITIALLY OBVIOUSLY, OTHER
• DOCTORS ARE ENVY BECAUSE OF OUR
  SUCCESS..

TAKE ADVANTAGE OF A UNIVERSAL HUMAN
WEAKNESS, BASED ON THE HOPE AND DESIRE
OF EACH AND EVERY ONE OF US, TO BE
YOUNG AND HEALTHY FOREVER
57
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??????? ???? 2/7/02 ????? ????-???????
????? ???? ????? ????-??????? ????? ???
???????? ?????? ???? ????? ??? ?? ?? ?????
??????.
?????? ???? ????? ?? ???? ?? ????? ?????
??????? ?????? ?????? ??????? ????
58
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
???????? ?????, ????? ????? ??????? ??????? ????
- ????? ????? ????? ???????? ???????? ???? ?????
?????? ?????? ???? ?????? ?? ?????-???????,
???? ???? ?????? ???? ???? ????? ?? ????????
???????
(????? ????, ????? ????? ????? ????? ???????,
????? ?????? ?????? ????? ?????? -??? ???? ?? ???
????? ???)
59
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
??? ??, ????? ????? ????????? ??????
???????? ??????
??????
????? ???? ???? ?? ??????? ?? ???? ?????? ???????
??????? ?????? ???? ????? ???? ????? ?????
????? ????? ??????? ?????? ????? ??????? ??
????? ??????? ????? ????? ????? (????-???????)
60
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
????? ????? ???? ????? ??????? ??????
??????? ????, ?? ???? ?????? ?????? ????
???? ?? ??????? ????? ?? ????
????? ?? ????? ???? ???? ??????? ?? ???????
???? ?????? ????? ?????? ??????? ???????
61
???? ????-??????? ?? ???? ??????? ????
????? ????? ?????????/?????? ?????????? ??????
?????
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
??"? - ?"? ??? ??????? - ?????? ??????/?????
????? ???? ????? (??? ?-?) ????' ????? ???? -
?????????????? ?"? ???? ??????? - ???????? ?"?
????? ??????? - ???????? (??"? ?????? ??????
??????? ??????? ????) ?"? ????? ???-????? ?????
(??? ??? ????? ????? ?????, ???? ???????) ????'
????? ??????? - ?????? ??????/????? ????? ???'
??? ???? - ?????? (???? ???? ?????? ??? ???????
?? ???? ???????) ?"? ????? ????-?????? - ?????
(??? ?????? ????? ??????, ???? ???????) ????' ???
??????? - ????????, ?????? ?????? ????' ???? ????
- ???? ????? ?????? ?????? ??????? ????' ?????
????? - ??????????? ????' ??????? ??? - ?????
??????
62
????? ??????? ???? ???? ??????????? ?? ?????
??????? ???? 2/7/02 ????? ????-???????
???? ????-??????? ?? ???? ???????
???? ???? ?????? ??????? ???? - ????? 2003,
????? ???????? ??? ??????? ???? ????' ???'?,
??"? ?????? ??????? ?????????, ??' ???? ??,
???? ???"? ???? ???????, ??????? ?????? ?????
????? ??????? ???????? ????? ??????. ???? ???????
???? ????? ????? ?????? ????? ??????? ???????
????.
63
?????? ????? ???? ???????
1. ???? ?? ????? ?????? ??????? ??? ???? ???"?
?????? ?. ??? ????? ??????? ??????? ????
?????? ??????? (aging process), ????? ??
????? ?? ?????? ???????. ?. ?????? ?????????
???????? ???? ????? ??????? ???? (age-related
diseases). ?. ????? ?????? ???? ?????? ?????
???? ????/????? ????? ????? ??????? ????????? ??
??? ????? ????? ?????? ?????? ?????
???????, ???? ???, ????? ????-????. ????? ??????
??????, ????? ??????, ?????, ????? ?????, ?? ???
???? ????, ???? ????? ?????????, ????? ?? ????
??? ????, ??????? ????? ???? ????, ???? ?????
??????-???????, ??????? ??????, ????? ?????
??????, ??????? ??? ????, ???????? ????? ????????
(?????/????? ?? ?????, ??-????? ??????? ??????,
??-????? ?????? ?????? ????, ??-????? ???? ??????
??-??????) ????? ???? ???? ?????? ?? ??? ???
????????? ??????? ????? ????? ??? ????? ???.
64
?????? ????? ???? ???????

• 1. ???? (????)
• ?. ??? ????? ??????/?????? ?????????? ?????
  ?????? "????-????'???"
• 1) ????? ????????? ???? ?????? ?????,DHEA ,
  ?????????, ???????, ?????? ????? ?????, ???????
• 2) ????? ?????? ?????
• 3) ????? ?????? ????/???? ???? ???????
• 4) ????? ????
• ????? ?????? ????? ??????

?. ????? "????-????'???" ?? ????? ?????? ???????
??????? ?????? ?????? ?? ?? ???? ????
?????? - ????? ????????, ??? ????? ?????? ??
?????? ????? ?????. ?. ?? ????? ??????
"????-????'???"/????? ?????? ??????? ????? ?"?
?????? ??????? / ?????? ??????? ???????
???? ?? ????"?.
65
???????
?. ?? ?????? ??????? ?????? ??-?????? ??????
?????? ??????? ????? ?????? ?? ???? ???????
"????-????'???" ??????? ??????? ?????? ??????
?????? ????? ????? ????? ????? ???????
????. ?. ?? ????? ???????? ??????? ?????? ???"?
?????? ????? ?????? ?????? ????
????-????'??? ???? ????? ???????? ???????? ?? ??
???-???? ????-????? ?????. ?. ?? ????? ?? 1) ???
?????? ?-2) ??????? ???????? ?? ????? ????? ????
????? ????? ?????? ?? ???????, ?? ???
??????? ??????? ????? ?????? ?"? ??????
????? "????-????'???. ?? ????? ??????? ?????
?????/????? ???????.
?. ?? ????? ????? ????? ????? ?????-????? ????
?????? ?? ??? ?????? ?????????, ??????
????????, ??????? ?????? ?????/?????? ?????? ?"?
??? ?????? ?? ????? ?????? ???????? ?????
?????? ??"? ??? ???? ???? ?????? ???? ???????
???????. ?? ???? ???? ???? ??????? ??????
????? ??????. ?? ????? ????? ???? ??? ?????
?????? ??????? ?????? ????? ?????? ???????
???-?????? ?????????. ?. ?? ????? ????? ??????
????????????? ????? ????? ????? ?????. ????? ????
??? ???????? ??, ??????? ???? ????? ??????
????? ????? ??? ????????? ?????? ??????, ??
?????? ?????? ???????? ??????.
66
HEALTH PROMOTION IN ADULTS (ANTI-AGING ?)
M A J O R I N T E R V E N T I O N S
GENE THERAPY
PHYSICAL ACTIVITY
AVOIDING / STOPPING SMOKING
WEIGHT LOSS
DIET ( FOOD SUPPLEMENTS / VITAMINS
MINERALS / ANTI OXIDANTS etc.)

• DRUGS

67
I N H I B I T I O N OF AGE RELATED DISEASES
PRIMARY SECONDARY PREVENTION OF
ATHEROSCLEROSIS (MI, STROKE, PVD, KIDNEYS)

DEVELOPING IMPROVED MEANS FOR EARLY DETECTION
ANTI COAGULATION PLATELET AGGREGATION
(ASPIRIN) CHOLESTEROL LOWERING DRUGS BLOOD
PRESSURE LOWERING DRUGS BETA BLOCKERS ACE
INHIBITORS VITAMINS?, ANTI OXIDANTS?
68
I N H I B I T I O N OF AGE RELATED DISEASES
PRIMARY SECONDARY PREVENTION OF
C A N C E R
DEVELOPING IMPROVED MEANS FOR EARLY DETECTION
GENETIC MANIPULATIONS? MONOCLONAL
ANTIBODIES ANTI COAGULATION PLATELET
AGGREGATION (SECONDARY, PRIMARY?) VITAMINS?, ANTI
OXIDANTS? DRUGS FOR SPECIFIC CANCERS (PREVENTION
CURE)
69
I N H I B I T I O N OF AGE RELATED DISEASES
PRIMARY SECONDARY PREVENTION OF
?
OSTEOPOROSIS
DEVELOPING IMPROVED MEANS FOR EARLY DETECTION
CALCIUM, OTHER MINERALS TRACE ELEMENTS?
VITAMIN D ESTROGENS RALOXIFEN BISPHOSPHONATES CAL
CITONIN, PTH EXTRACTS? (SECONDARY)
70
I N H I B I T I O N OF AGE RELATED DISEASES
PRIMARY SECONDARY PREVENTION OF
DEMENTIA, ALZHEIMERS
DEVELOPING IMPROVED MEANS FOR EARLY DETECTION
EDUCATION MENTAL SOCIAL ACTIVITIES VASCULAR
PROTECTION ( B.P., CHOLESTEROL LOWERING,
etc.) DONEPEZIL, RIBOSTIGMIN ESTROGENS ? ANTI
INFLAMATORY DRUGS (NSAID) ?
71
I N H I B I T I O N OF AGE RELATED DISEASES
PRIMARY SECONDARY PREVENTION OF
DEPRESSION
DEVELOPING IMPROVED MEANS FOR EARLY DETECTION
PSYCHOLOGICAL MEANS AVOIDING SOCIAL
ISOLATION TREATING UNDERLYING MEDICAL CAUSES D
R U G S ? ?