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Human Chorionic Gonadotropin (hCG):

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Title: Human Chorionic Gonadotropin (hCG):


1
???????????
  • Human Chorionic Gonadotropin (hCG)
  • The Story Of Pregnancy Hormone

???
2
General introduction
  • ?????????
  • Human Chorionic Gonadotropin (hCG)
  • MeSH
  • Chorionic Gonadotropin
  • Placental Hormones
  • Pregnancy Proteins

3
General introduction
  • hCG????????????,????????????????hCG??????,????????
    ????,????????,?????????hCG
  • ???hCG???????????????,???????????hCG???????????

4
General introduction
  • ??LH????,????, ???????,??????
  • hCG???????????????(steroidogenesis),??????????????
    (testosterone)
  • ?hCG???????6?,?hCG?12-14????
  • ?????48-72 h,?????????,?????? 96 h???8 - 10
    w??,???????????

5
General introduction
  • ?FSH?LH?TSH??,??a?ß????????a?????????????????,????
    ?????,??????ß???
  • ?????ß-HCG,?????????

6
Key things about hCG levels (1)
  • ?hCG??????????? ?????hCG?????????????
  • ??????hCG??(5 - 6 ???? )????

7
Key things about hCG levels (2)
  • ???? ???????(beta hCG)??
  • The hCG hormone is measured in milli-international
    units per milliliter (mIU/ml)
  • ?????lt 5mIU/ml ??
  • gt 25mIU/ml ??????

8
Key things about hCG levels (3)
  • ??????? 1,000 - 2,000mIU/ml
  • ??????????????,???hCG??????,???????????????????
  • ???????,?????????????????

9
Guideline to hCG levels during pregnancy
  • 3 weeks LMP 5 - 50 mIU/ml
  • 4 weeks LMP 5 - 426 mIU/ml
  • 5 weeks LMP 18 - 7,340 mIU/ml
  • 6 weeks LMP 1,080 - 56,500 mIU/ml
  • 7 - 8 weeks LMP 7, 650 - 229,000 mIU/ml
  • 9 - 12 weeks LMP 25,700 - 288,000 mIU/ml
  • 13 - 16 weeks LMP 13,300 - 254,000 mIU/ml
  • 17 - 24 weeks LMP 4,060 - 165,400 mIU/ml
  • 25 - 40 weeks LMP 3,640 - 117,000 mIU/ml
  • Non-pregnant females lt5.0 mIU/ml

10
False positive of hCG?
  • ?ß-HCG????????????????,?????????,?????
  • - ??????????????????hCG??,????????????
  • - ???????????????????,????????hCG
  • - ??????????,?????????hCG???

11
What can a low hCG level mean?
  • A low hCG level can indicate
  • -????
  • -????(????)
  • -????
  • rechecked within 48-72 hours to see how the level
    is changing.

12
What can a high hCG level mean?
  • A high hCG level can indicate
  • -????
  • -???
  • -????
  • rechecked within 48-72 hours to evaluate changes
    in the level.

13
Should hCG level be checked routinely?
  • ???????????,????
  • ????
  • - ????
  • - ??(??)
  • - ???

14
hCG levels after a pregnancy loss?
  • ?????????4 - 6 weeks??(lt5.0 mIU/ml)
  • ????,??????? (????, ??????, ????,2 weeks)
    ,??????
  • ?????? lt5.0 mIU/ml

15
?????HCG???(mIU/ml) ?????HCG???(mIU/ml) ?????HCG???(mIU/ml)
????? 12 34 56 78
5 70 66 12.5 19.5
??? 950 260 49 41
95 5750 2450 330 140
16
?????HCG??? (mIU/ml) ?????HCG??? (mIU/ml) ?????HCG??? (mIU/ml)
????? 15 610 1115 1620
5 lt12.5 lt12.5 lt12.5 lt12.5
??? 15000 230 92.5 57.5
95 46500 3250 490 205
17
Applications
  • Prengnancy diagnosis
  • Ectopic pregnancy
  • Hydatidiform mole
  • GTN
  • PSTT
  • Assistant reproduction
  • Contraception

18
Others
  • ?????4-8?,HCG??2-3d?????
  • LMP?7?,???????????????,HCG?20000mU/ml?
  • ?9-10???????,??????lt5ng/ml??????(?????????),gt25ng
    /ml?????????

19
Others
???????????????? ???????????????? ???????????????? ????????????????
?? ng/ml ng/L  
7 24.5 76.4  
8 28.6 89.2  
912 38 118.6  
1316 45.5 142  
1720 63.3 197.5  
2124 110.9 346  
2534 165.3 514.8  
gt35 202 630  
20
Others
  • ?8-13?????????,?????????????????(cm)6.5
  • ??????2cm?????????,?????5mm????????

21
The End
  • THANKS FOR YOUR ATTENTION!
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