Patrick

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Patrick An Introduction to Medicinal Chemistry
3/e Chapter 22 ANTIULCER AGENTS Part 2
Helicobacter pylori
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Contents Part 2 Helicobacter pylori 21. Feature
s of H. pylori (3 slides) 22. Treatment of H.
pylori 5 slides
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21. Features of H. pylori

• Spiral, curved bacterium
• Grows best in oxygen concentrations of 5
• Naturally present in the stomachs of many people
• Attaches to a sugar molecule on the surface of
  the cells lining the stomach wall
• The organism secretes proteins and toxins that
  inflame the stomach lining
• Responsible for the recurrence of esters
• The organism is protected by the mucus layer
• A pH gradient across the mucus layer means that
  the pH is near neutral at the stomach lining

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21. Features of H. pylori
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21. Features of H. pylori

• Bacterium produces urease enzyme
• Neutralises any acid in the local environment

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22. Treatment of H. pylori

• Triple therapy of a proton pump inhibitor and two
  antibiotics
• Antibiotics work better at a higher pH than is
  normally present in stomach
• The proton pump inhibitor is present to raise the
  pH
• Example