?????????? Insulin and Oral Hypoglycemic Drugs

1
??????????Insulin and Oral Hypoglycemic Drugs

• Diabetes is not a single disease. Instead,
  it is a heterogeneous group of syndromes all
  characterized by an elevation of blood glucose
  caused by a relative or absolute deficiency of
  insulin.Frequently the inadequate release of
  insulin is aggravated by an excess of glucagon.

2
INTRODUCTION
INSULIN
SULFOUNYLUREAS
THIAZOLIDINEDIONE
a GLUCOSIDASE INHIBITOR
BIGUANLDES
SUMMARY
3
INTRODUCTION
4
INTRODUCTION
5
INSULIN(???)
6
INSULIN (???)
7
SULFOUNYLUREAS(????)
8
SULFOUNYLUREAS (????)
9
SULFOUNYLUREAS (????)
10
SULFOUNYLUREAS (????)
11
THIAZOLIDINEDIONE(?????)
12
THIAZOLIDINEDIONE (?????)
13
aGLUCOSIDASE INHIBITOR ( a-????????)
14
BIGUANLDES(???)

• METFORMIN(???)
• PHENFORMIN(????)
• BUFORMIN(???)

15
SUMMARY
HYPOGLYCEMIC DRUGS
INSULIN Regular insulin Semilante insulin Lante
insulin Rotamine zinc insulin Protamine zinc
insulin Ultralante insulin
ORAL HYPOGLYCEMIC DRUGS Sulfonylureas
Tolbutamide
Chlorpropamide
Glibenclamide Biguanldes
Metformin
Phenformin -Glucosidase inhibitor Acarbose

Voglibose Thiazolidinedione
Rosiglitazone
Ciglitazone