Easyef

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Easyef Ointment Recombinant Human Epidermal
Growth Factor
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General Information
Easyef Ointment
What is EGF?

• Epidermal Growth Factor (EGF) is a single-chain
  polypeptide consisting of 53 amino acids with a
  molecular weight of about 6,200 Daltons. Six
  cysteine residues in the sequence of hEGF from
  three disulfide bonds are required for hEGF to be
  biologically active.
• EGF was first isolated from the submaxillary
  glands of adult male mice. Human EGF was
  discovered in human urine as an inhibitor of
  gastric acid secretion. Today, hEGF has become
  one of the most attractive growth factors in life
  sciences as well as biotechnological fields.
• Human EGF is a potent stimulator of epithelial
  and endothelial cells and fibroblast
  proliferation both in vitro and in vivo, which
  results in its potential as a promising healing
  agent for the treatment of various skin and
  corneal wounds. In dermatology, EGF can be used
  as a healing agent for skin wounds, such as
  diabetic ulcers, bed sores, venous stasis ulcers,
  skin burns and surgical incisions. In
  ophthalmology, EGF can be utilized as a healing
  agent for corneal ulcers and ophthalmic surgery,
  such as corneal transplantation and excimer laser
  keratectomy, and the prevention of corneal
  degeneration. It is also a good candidate for the
  treatment of gastric ulcers because it inhibits
  gastric acid secretion and regenerates gastric
  mucosal layer.

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Easyef Ointment
Mechanism of EGF Action

• 1. Re-epithelialization
• EGF promotes epithelial cells to proliferate and
  move to fill wounds.
• 2. Promotion of granulation tissue
• EGF stimulates fibroblasts in dermal tissue to
  facilitate dermal cells to differentiate and
  proliferate.
• 3. Angiogenesis
• EGF promotes endothelial cells to proliferate to
  regenerate blood vessels.

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Skin Regeneration and the Healing Effect
Easyef Ointment
1. Non-clinical study
2. Clinical study
? Indication Wound healing (Skin graft donor
site model) ? Methodology Placebo-controlled,
randomized, double-blind, multi-center study ?
Primary endpoint Healing time by the direct
evaluation(naked eye) of skin graft donor site ?
Result The test group displayed statistically
significant 1.0 day faster healing time
compared to the control
group (p0.0005).
ITT N64 ITT N64 PP N61 PP N61
Placebo EGF 1 µg/g Placebo EGF 1 µg/g
Healing time (day) (meanSD) 8.1091.492 7.6091.344 8.1071.528 7.5981.363
Healing time difference (day) (meanSD) median (min, max) 0.5001.098 1.000 (-1.500, 3.500) 0.5001.098 1.000 (-1.500, 3.500) 0.5081.116 1.000 (-1.500, 3.500) 0.5081.116 1.000 (-1.500, 3.500)
p-value 1) 0.0005 0.0005 0.0007 0.0007
95 confidence interval 0.500, 1.000 0.500, 1.000 0.000, 1.000 0.000, 1.000
1) Wilcoxon signed- rank test
Outstanding effect of skin generation The wound
applied with Easyef Ointment demonstrated the
quickest healing ability. Rapid wound healing
ability The shortest healing time was achieved in
the same wound area.
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Key Benefits and Features
Easyef Ointment
Wound healing ointment with a new concept,
containing EGF, a granulation ingredient
(granulation tissue) in the human body, offered
first in Korea. Safe because it contains no
steroids or antibiotics. White blood cells or
macrophages themselves, which are created during
the healing process in our body, suppress
bacteria, to some extent. Therefore, this
medicine does not contain a steroid or an
antibiotic of which the excessive use may make us
tolerant of the antibiotic. Proven in its safety
and healing effect through a clinical studies in
Korea. Top medical staffs from three prestigious
Korean Institutions (Asan Medical Center,
Severance Hospital, and Samsung Medical Center)
joined the clinical procedures, and approved the
safety and remarkable healing effect of EGF.
Table of Comparison with Competitors
Product name Easyef Ointment A B C
API EGF (Epidermal Growth Factor) Sodium fusidate Mupirocin Centella asiatica extract
Type No antibiotic No steroid Antibiotic Antibiotic Antibiotic, steroid
Tolerance/ Side effect Same ingredient as in the human body (no side effect) Tolerance (antibiotic) Tolerance (antibiotic) Tolerance (antibiotic) Side effect (steroid)
Efficacy/ Effect Assistive topical treatment of wound and skin ulcer Pyoderma, acne, folliculitis, boil, and secondary infection due to a burn and wound Bacterial skin disease   Skin inflammation, infected wound
Storage Store in a refrigerator (28?) Room temperature (130?) Room temperature (130?) Room temperature (130?)
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Product Information
Easyef Ointment
Component In 1 g Recombinant human epidermal
growth factor ------------------------------ 1
µg (Host E. coli JM101, Vector pTE105) Ointment
base white petrolatum (KP) ----------------------
-------------- 700 mg Ointment base Light liquid
paraffin (KP) -----------------------------
298.45 mg Preservative propylparaben (KP)
------------------------------------------- 1.5
mg Appearance Colorless or pale yellow,
translucent ointment in tube Administration/Dosag
e Apply it to the infected area several times a
day as needed. Efficacy/Effect Assistive topical
treatment of wounds and skin ulcers Storage
Store in a refrigerator (28?).
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Easyef Ointment
Release Date 2010.12.30 http//www.daewoong.com
For More Information Contact Chang-woo Suh
Tel [phone] E-mail
cwsuh_at_daewoong.co.kr 163-3, Samsung-dong,
Gangnam-gu, Seoul 135-715, KOREA