Mutations Foldable

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Mutations Foldable

1. Fold 3 pieces of paper, so you have 5 layered
   flaps
2. Write Mutations on the top flap as a title

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On each flap write

1. What is a mutation?
2. Point Mutations
3. Chromosomal Mutations
4. Advantages/Disadvantages
5. Real Life Example

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1. What is a mutation?
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(Inside) On Top Half of 1st Flap write

• Mutations- any change in DNA that may affect the
  expression of a gene
• Proteins that produced as a result of mutations
• may fail to function
• may change the phenotype of an organism
• Mutations can be caused by mutagens.
• Examples from the environment- UV light,
  chemicals, radioactive substances, X-rays

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(Inside) On Bottom Half of 1st Flap

• Glue in the following picture Label the
  following
• Strand D- DNA was mutated by UV light circle the
  5th base- it should be T but now is C
• Strand H- mRNA is made from mutated DNA template
  during transcription circle the 5th base- it
  should be A but now is G
• Stand N- Polypeptide chain (amino acid sequence)
  circle the 2nd amino acid (THIS IS THE WRONG
  AMINO ACID!)
• O- Mutation is seen here first mutation causes
  no color pigment to occur
• Flowers have no color!

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2. Point Mutations
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(Inside) On Top Half of 2nd Flap write

• Point Mutations- a change in a specific base in
  the DNA that causes a shift in the reading
  frame ? causes a change in codons

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(Inside) On Bottom Half of 2nd Flap write

• TYPESGlue in the following picture Label the
  following
• Circle the substitution that has occurred next
  to the picture write Substitutions occur when
  one base is changed
• Circle the deletion that has occurred next to
  the picture write Deletions occur when one base
  is removed or lost
• (3) Circle the insertion that has occurred
  next to the picture write Insertions occur when
  one base is added to a sequence of DNA

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3. Chromosomal Mutations
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(Inside) On Top Half of 3rd Flap write

• Chromosomal Mutations- a change in a specific
  segment of the DNA ? both positive and negative
  affects
• cause a protein to malfunction
• cause a different protein to be made

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(Inside) On Bottom Half of 3rd Flap write

• TYPESGlue in the following picture Label the
  following
• Color the segment of DNA that has been deleted
  next to the picture write Deletions occur when a
  segment of DNA has been removed
• Color the segment of DNA that has been inverted
  next to the picture write Inversions occur when
  a segment of DNA has been flipped
• Color the segment of DNA that has been
  translocated next to the picture write
  Translocations occur when a segment of DNA has
  moved to a different location on another
  chromosome
• Color the segment of DNA that has been
  duplicated next to the picture write
  Duplications occur when another copy of a segment
  of DNA is made

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4. Advantages/Disadvantages of Mutations
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(Inside) On Top Half of 4th Flap write

• ADVANTAGES
• New forms of a trait
• Drug resistance
• Antibiotic resistance

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(Inside) On Bottom Half of 4thFlap write

• DISADVANTAGES
• Absence of a trait
• Cancer
• Diseases/Genetic Disorders
• Sickle Cell Anemia

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5. Mutations in the Human Body
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Examples of Disease that cause mutations
Sickle Cell Anemia
Next to picture Explain the mutation