MAD COW and Similar Diseases

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MAD COW and Similar Diseases

• What Are They?
• by Norbert Fischer

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Spongy Brain Disease

• Transmissible

Spongiform
Encephalopathy
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Common TSE s

• Sheep Scrapie
• Cattle .. Mad Cow
• Humans . Kuru, CJD, nvCJD

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Scrapie

• 1700s
• Scratching
• Incoordination

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BSE

• 1986
• Bovine SE
• Mad Cow

TIMELINE gt
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Kuru

• 1920 1960s
• Tremor to death in 3-6 mths
• Cultural practices
• slow virus?? 2-23 yrs !

P.N.G. MAP gt
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CJD

• Creutzfeldt-Jacob Disease
• Worldwide
• Madness, death
• Three types of cause

3 TYPES gt
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nvCJD new variant CJD

• human Mad Cow
• Symptoms more like
• Kuru than CJD
• Linked, not proven

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nvCJD new variant CJD

• human Mad Cow
• Symptoms more like
• Kuru than CJD
• Linked, not proven

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TSE Questions

• Replicable?

• Transmissible?

• Heritable?

• Sporadic?

• Cultural?

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TSE Qustions

• Replicable?

• Transmissible?

• Heritable?

• Sporadic?

• Cultural?

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Under the Lens

• Amyloid
• No immunological reaction

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Abnormal Protein

• folding
• resists enzymes
• resists cooking
• induces more

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Prion
Protein infection

• a fibril
• an infection
• a life form ?

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Significance

• Numbers
• Cultural Practices- recycling, medical, GM
  food
• Related Diseases ?
• More ? ? ?

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thanks
SO

• A pathological process
• Still much unknown