HARMONY Study of Dementia in Swedish Twins

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HARMONY Study of Dementia in Swedish Twins
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• health Hälsa
• genes ARv
• environment Miljö
• and Och
• new NY

NIA grant R01AG08724 and the Alzheimers
Association
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The Swedish Twin Registry
Old Cohort Born 1886-1925 (10,945 pairs)

Computer Assisted Telephone Interviews
1998-2001
Questionnaires 1961, 1963, 1967 (1970)
Middle Cohort Born 1926-1958 (13,665 pairs)
N 20,269 Individuals aged 65 (MZ, same sex
DZ, and opposite sex DZ)
Questionnaire 1973
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Swedish Twin Data for Studies of Cognitive Aging
and Dementia
Swedish Twin Registry
HARMONY
Old Middle SATSA SALZA
Gender I Cohort Cohort OCTO-Twin
1970 1980 1990 2000
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(No Transcript)
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Registry Linkage
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Inpatient Psychiatric Registry
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Dependent Variable

• Clinically diagnosed Alzheimers disease
• Clinically diagnosed dementia
• Cases screened as suspects and diagnosed with
  dementia
• Controls screened as not suspects
• Cognitive dysfunction
• Screening outcomes
• Registry diagnosed dementia

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Samples for Analysis of Dementia

• Case-control
• N 547 cases, 12133 controls
• Co-twin control
• 140 pairs
• Discordant MZ pairs
• Enhanced by registry linkage
• 106 twin pairs
• Prospective dementia cohort

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Summary of published results

• Basic description of study
• Heritability
• Cognitive screening
• Age of onset
• Early life risk factors
• Occupation
• Cancer
• Education
• Personality