???????(human leukocyte antigen, HLA),?????,??????MHC?HLA???HLA?????,????????HLA???HLA?? ?

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• ???????(human leukocyte antigen,
  HLA),?????,??????MHC?HLA???HLA?????,????????HLA???
  HLA?? ?

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??? MHC?????????

• MHC?????,??????
• ????
• ???

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• ???????????????????????,???????????????

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• ?????????? ? ???
• ????????
• ?????????????,?????????????,????T????????,
  ??????????
• ???????????
• ????????,????? ? ? ???,????????,???????????
  ?,??????????????

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??? HLA?????????? ?????
1)?????????,???????????,?????????????????????????
? HLA?????????? ??I???
??II??? ???????? A B C DRA DRB1
DRB3 DQA1 DQB1 DPA1 DPB1 E G TAP 250
490 119 3 315 38 22 53
20 99 6 15 10
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?4?? ? ??????a??a1?a2?????????,????????? ?
Ig??a3 ?CD8????????ß2 -m??????a3???????????? ?
??????????????,?? ??? ? ??????????,????????????
?????????????????,?????????,???????????????
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(?)????MHC
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??????HLA???????????

• ???????MHC????(?????)?????????(????????????????,?
  ???????????????)
• ????(anchor residue)?????
• ????

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??????MHC?????????

• ??MHC???????????????,?? ?????
• ???MHC?????????????????,?????????????????,??MH
  C??
• ???(flexibility)MHC??????????????????????,???
  ????MHC???????????????????,???MHC???????????????
• ????????????

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(?) HLA??????? 1. HLA ????????
???????????????????,??CTL?????????????,???????????
???? 2. HLA ???????? ????
IFN-? ????MHC ???? ???????????????????
????T???
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