Photodynamic Therapy

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Photodynamic Therapy
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Phototherapy

• The first who used the light Egyptians, Indians,
  Chinese and Grecee
• 1815. Carvin
• 1822. Sniadecki
• 1903. D. N. Finsen Nobel Prize

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Photochemotherapy

• Indians Psoralea corylifolia
• Egyptians Ammi majus

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PDT history

• 1900. Oscar Raab
• 1905. H. von Tappeiner take in the PDT

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Hematoporphyrin

• 1841. Sherer
• 1867. Thudicum
• 1871. Hoppe- Seyler

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Hematoporphyrin

• 1924. Policard
• Auler and Banzer
• Figge and co workers photodiagnosis

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Why do some photosensitiziers localize
selectively in tumors?

• Tumors have a larger interstital volume than
  normal tissues
• Tumors often contain a larger fraction of
  macrophages than normal tissues
• Tumors have a leaky microvasculature
• Tumors have poor lymphatic drainage
• The extracellular ph is low in tumors
• Tumors contain a relatively large amount of newly
  synthesized collagen
• Tumor tissue contains many receptors for
  lipoproteins

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PDT treatment
Use photosensitizing solution
Collect in cancer
Selective tumour collapse
Irradiate
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Porfirin
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PDT mechanism

• Energy transport ? reactive oxygen

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PDT mechanism

• Electron passing ? free radical

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PDT mechanism
photosensitizing
Activation with light
Introduce photosensitizing into the cell
release reactive oxygen end free radical
tissue necrosis or apoptozis
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Other tumour therapy

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  Surgery
• disadvantage - cant remove total the cancer
• - matastasis
• Radio-
  and chemotherapy
• disadvantage - to hight degree damage
• - resistance

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Photodynamic Therapy

• Advantage
• - selective destruction
• - not develop resistance
• Disadvantage
• - only use surface cancer
• - cell of small size

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Other field of application

• Arteriosclerosis
• Germ, virus inanctivation
• Gum inflammation
• Blood sterilization
• Water purification

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