BCIRG

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• Prof. Jean-Marc Nabholtz, MD, MSc
• Chairman

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Cancer Therapy Development
ADJUVANT
Nabholtz, May, 2001
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Evolution

• BCIRG is the Breast Cancer division of CIRG
  (Cancer International Research Group)
• Present evaluation of potential other divisions
• Disease sites eg. LCIRG, GICIRG
• Mechanistic groups Kinase Inhibitors IRG
  others?...
• Integration of activities in Global
  Translational Processes.
• with UCLA/JCCC and other Universities
• Development of Translational Tools (Cancer
  International Tumor Bank).

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Global Translational Processes
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Multistep Process 7 major steps

• 1. Identification of Gene abnormalities
• 2. Determination of relevance in human cancers
• 3. Pathway Identification
• 4. Identification of therapeutic interventions
• 5. Identifications of patients sub-populations
  with given abnormality / Tests
• 6. Identification of predictive factors / Tests
• 7. Pivotal clinical development

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Translationnal Multistep Process(7 of 7)

• Pivotal Global Clinical Development
• Acces to multiple targeted subpopulations in a
  timely fashion for proof of concept in humans
• CIRG
• First Academic Global Translational Intergroup

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Meeting the Challenges

• Phenomenal acceleration of new compounds
• Emergence of targeted therapies in subpopulations
• Concept of biology based individualized therapy
• Need to define new models of development and
  define new translational strategies
• Patient Access
• Overall stable number of patients
• Targeted therapies Need to study subpopulations
• Need for new processes for developing new drugs

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Summary Science is our guide

• BCIRG and CIRG were created to meet that need
• The concept has been proven to work
• Integrated Translational approach
• Academic Global Translational collaboration

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