NIMH MEG Core Facility

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NIMH MEG Core Facility
Magnetoencephalography Imaging Resource, IRP,
NIMH / NINDS
Data Processing
Facility Description
Recent Studies
The MEG Core Facility is resource serving the
intramural research programs of the NIMH and
NINDS for IRP investigators to perform functional
neuroimaging studies to further the understanding
of healthy and diseased brain function and
physiology. The facility provides a complete
environment for stimulus presentation, monitoring
and recording subject behavior and physiology
while recording magnetoencephalographic data.
Time-course of cortical activation relative to
response for 2-back vs 0-back
Co-Registering with MRI
Fiducial points marked on MRI using AFNI
Head Coils placed on Fiducials
The core operates a CTF OMEGA whole head MEG
system (275 MEG and 64 EEG channels) from VSM
MedTech. Services include providing for temporary
data storage, data transfer, instruction on
running the instruments, as well as aid with
signal processing and analysis.
Brain Res. 2008 Dec 91244103-12.
Time-Frequency Analysis using the Stockwell
Transform
Basic Concepts
Comparison of temporal and spatial resolution for
various neuroimaging methods.
Time resolution of MEG allows for detailed
frequency response analysis of a five auditory
click experiment.
Dual-State Beamformer Imaging using SAMimg
User Information

• Obtain Protocol Approval
• Users are required to have an NIH IRB-approved
  protocol describing the intended MEG research.
• Request a User Account
• A Facility Access Request form must be filled out
  to establish a user account.
• The account will give access to the scheduling
  calendar and also provide access to the MEG Core
  Facility data storage system.
• Attend MEG Orientation
• New users will be given a tour of the facility,
  at which time the operation of the scanner,
  facility rules, etc., will be discussed.
• Staff can discuss in detail Issues related to
  experimental design, data analysis,
• Experiment Setup / Piloting
• The MEG Core Facility Staff can assist users in
  task design, programming, and other aspects of
  actually running the experiment.

System Overview
Comparison to fMRI
BOLD fMRI was collected at 3T with an identical
task design. Data were structurally aligned,
smoothed, and MNI normalized using SPM99. Single
subject contrast maps for 2-back gt 0-back were
followed by a group analysis.
Resources
The MEG Core Facility website (http//kurage.nimh
.nih.gov/) provides information and scheduling to
the user community. The site includes user
guidelines and training plans, manuals,
tutorials, as well as forms for requesting
access, user accounts and scheduling as well as
software and scripts for data processing. Contact
information Dr. Richard Coppola, Director

coppolar_at_mail.nih.gov
Dr. Tom Holroyd, Staff Scientist
tomh_at_kurage.nimh.nih.
gov
At a comparable p level threshold the MEG for a
window around the response showed beta
desynchronization with a very similar spatial
extent to the BOLD activation. This relationship
will be important for better understanding of the
physiological basis of neuroimaging activation.