Title: The Nervous System
1The Nervous System
Ode To The Brain http//www.wimp.com/brainautotune
d/
2The BasicsThe nervous system is your body's
decision and communication center.
- The central nervous system (CNS) is made of the
brain and the spinal cord - The peripheral nervous system (PNS) is made of
nerves.
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4Neurons
- A neuron is a nerve cell that is the basic
building block of the nervous system and are
specialized to transmit information throughout
the body. - Job communicating information in both chemical
and electrical forms. - 3 main types
- 1. Sensory neurons (afferent) carry information
from the sensory receptor cells throughout the
body to the brain. - 2. Motor neurons (efferent) transmit information
from the brain to the muscles of the body. - 3. Interneurons are responsible for
communicating - information between different neurons in
the body. - Well get back to these later..
5Do Now!
- What are the two main parts of the nervous
system? - What organs are these two parts made up of?
- What is a neuron?
- What are the 3 different kinds of neurons?
6Use the definitions below to correctly label this
neuron
- axon - the long extension of a neuron that
carries nerve impulses away from the body of the
cell to other neurons. - axon terminals - the hair-like ends of the axon
- cell body - the cell body of the neuron it
contains the nucleus (also called the soma) - dendrites - the branching structure of a neuron
that receives messages (attached to the cell
body) - myelin sheath - the fatty substance that
surrounds and protects some nerve fibers node of
Ranvier - one of the many gaps in the myelin
sheath - this is where the action potential
occurs during saltatory conduction along the axon
- nucleus - the organelle in the cell body of the
neuron that contains the genetic material of the
cell - Schwann's cells - cells that produce myelin -
they are located within the myelin sheath.
7Ready for the answers?
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10Neurons
Neuron Parts Soma body of the cell (main
space contains nucleus/DNA) Dendrites receive
messages from neurons Axon sends messages to
other neurons
Anatomy of a nerve http//www.youtube.com/watch?v
XgIaAs_ONG4featurerelated
11Two parts of Nervous system Neuron video clip
- The Nervous System
- http//www.youtube.com/watch?vxx--f9Y8wjg
The Teenage Brain on NOVA http//www.pbs.org/wgbh
/pages/frontline/video/flv/generic.html?sfrol02p3
92continuous1
12How messages are sent and received
- Neurons send messages electrochemically. This
means that chemicals cause an electrical signal. - Chemicals in the body are "electrically-charged"
-- when they have an electrical charge, they are
called ions.
Watch Bill Nyes Greatest Science Discoveries on
Neutrotransmitters.
13How messages are sent and received continued
- Resting Membrane Potential At rest, there is an
excess of negative ions inside the neuron
compared to the outside. -
14How messages are sent and received continued
http//www.teachertube.com/viewVideo.php?video_id
153535
- Action Potential
- When a message is incoming, the membrane opens at
that point, and positively charged ions flow in. - This process is repeated along the length of the
membrane, creating the neural impulse that
travels down the axon, causing the neuron to
fire. -
- Electrical changes during the action
potential.The incoming message must be above a
certain threshold to cause a neuron to fire.
After it fires, the neuron is returned to its
resting state. This process happens very quickly,
and within a few thousandths of a second the
neuron is ready to fire again.
15Myelin and Nodes of Ranvier
- The axons of the nerve cells are sheathed in a
smooth fatty protein called myelin which
insulates the axon. It considerably increases the
speed that nerve impulses travel along the axon. - Without the myelin, the axons would have to be
about one hundred times their volume to achieve
the same speed of nerve transmissions. The myelin
is wrapped around the axon in many thin layers.
The myelin does not enclose the axon in one
entire sheath, but has gaps at intervals called
the nodes of Ranvier.
16What causes the change in potential to occur?
- A stimulus causes the sodium gates (channel) to
open and, because there's more sodium on the
outside than the inside of the membrane, sodium
then diffuses rapidly into the nerve cell. - 2. All these positively-charged sodium ions
rushing in causes the membrane potential to
become positive (the inside of the membrane is
now positive relative to the outside). The sodium
channels open only briefly, then close again. - 3. The potassium channels then open, and, because
there is more potassium inside the membrane than
outside, positively-charged potassium ions
diffuse out. As these positive ions go out, the
inside of the membrane once again becomes
negative with respect to the outside.
17From One To The Next
- A chemical message (called a neurotransmitter)
passes from the sending neuron to the receiving
neuron. - The neurotransmitters leave the sending neuron
and enter the space between the sending and
receiving neurons. This space is called the
synapse or synaptic cleft. - The neurotransmitters then hook up to a receptor
on the receiving neuron to deliver their message.
18- Once neurotransmitters have sent their message,
they can be reabsorbed by the sending neuron in a
process called reuptake. - Reuptake allows the messengers to be reused.
- Two of these neurotransmitters are serotonin and
norepinephrine
Reuptake of serotonin occurs when some of the
serotonin that is passed from the presynaptic
neuron is recycled back into that neuron (see
upward arrows and F). SSRIs (P) block this
reuptake by blocking the channels (B) which allow
for this reuptake of the serotonin (C). This
increases the amount of serotonin in the synaptic
cleft that can bind with receptors on the
postsynaptic terminal.
19Antidepressant Meds
- SSRI
- Low levels of serotonin and norepinephrine in the
synapse are associated with depression and
sadness. Some medications used to treat
depression work by increasing the amount of
certain neurotransmitters that are available to
carry messages. - Antidepressants, such as selective serotonin
reuptake inhibitors, or SSRIs, work by slowing or
blocking the sending neuron from taking back the
released serotonin. In that way, more of this
chemical is available in the synapse. - The more of this neurotransmitter that is
available, the more likely the message is
received, and depression is reduced. - MAO INHIBITORS
- The antidepressants known as MAO inhibitors, or
MAOIs, affect neurotransmitters differently.
Monoamine oxidase (MAO) is a natural enzyme that
breaks down neurotransmitters. The drug MAOI
disrupts the action of the enzyme MAO. In that
way, there is an increase in the amount of
neurotransmitters in the synapse, making more
messengers available to the receiving neuron, and
thus reducing depression.
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21Neuron parts
- http//garyfisk.com/anim/neuronparts.swf
- Animated visual http//www.classzone.com/cz/books
/bio_07/get_chapter_group.htm?cin9rganimated_bi
ologyatanimated_biologyvaranimated_biology
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23Quiz Time! Name the ..
- 1. Part of the neuron that releases
neurotransmitters into the synaptic cleft. 2.
Fatty material that surrounds some axons. 3.
Part that takes information away from the cell
body. 4. The gaps in the myelin sheath. 5. Part
of neuron that contains the nucleus. 6. Part
that takes information to the cell body. 7.
Organelle in neuron that contains genetic
material.
Answers are 1. Axon terminal 4. Nodes of
Ranvier 7. Nucleus 2. Myelin 5. Soma 3.
Axon 6. Dendrites
24The Central Nervous System
young frankenstein part 1
- Interesting Facts!
- The central nervous system is divided into two
parts the brain and the spinal cord. - The average adult human brain weighs 1.3 to 1.4
kg (approximately 3 pounds). - The brain contains about 100 billion nerve cells
(neurons) and trillions of "support cells" called
gila. - The spinal cord is about 43 cm long in adult
women and 45 cm long in adult men and weighs
about 35-40 grams. - The vertebral column, the collection of bones
(back bone) that houses the spinal cord, is about
70 cm long. Therefore, the spinal cord is much
shorter than the vertebral column.
The Brain The Inside Story http//watch.thirteen
.org/video/1896942975/
25The CNS The Brain
26- The cerebrum -- which is just Latin for "brain"
-- is the newest (evolutionarily) and largest
part of the brain as a whole. It is here that
things like perception, imagination, thought,
judgment, and decision occur. - The surface of the cerebrum -- the cerebral
cortex -- is composed of six thin layers of
neurons (nerve cells) and is refered to as the
grey matter. It sits on top of a large
collection of white matter pathways. - The cortex is heavily convoluted with ridges
called gyri and valleys called sulci. If you
were to spread the cortex out, it would actually
take up about 2 1/2 square feet (2500 sq cm). It
includes about 10 billion neurons, with about 50
trillion synapses! - The cerebral cortex is divided into four
sections, called "lobes" the frontal lobe,
parietal lobe, occipital lobe, and temporal lobe.
27The Brain
The cerebral cortex is comprised of the frontal
lobe, parietal lobe, occipital lobe, and temporal
lobe.
28What do each of these lobes do?
- Frontal Lobe- associated with reasoning,
planning, parts of speech, movement, emotions,
and problem solving
29Functions associated with the frontal
lobes Conscious thought Concentration
Perseverance Judgment Attention span Impulse
control - self monitoring and supervision
Problem solving Organization Critical thinking
Forward thinking Ability to feel and express
emotions Empathy
YouTube - NEURONS AND NEURO-TRANSMITTERS
30What do each of these lobes do?
- Frontal Lobe- associated with reasoning,
planning, parts of speech, movement, emotions,
and problem solving - Parietal Lobe- associated with movement,
orientation, recognition, perception of stimuli
31Parietal Lobe
- The parietal lobes can be divided into two
functional regions. - One involves sensation and perception and the
other is concerned with integrating sensory
input, primarily with the visual system.
32What do each of these lobes do?
- Frontal Lobe- associated with reasoning,
planning, parts of speech, movement, emotions,
and problem solving - Parietal Lobe- associated with movement,
orientation, recognition, perception of stimuli - Occipital Lobe- associated with visual processing
33Occipital lobes
- The OC are the center of our visual perception
system. They are not particularly vulnerable to
injury because of their location at the back of
the brain, although any significant trauma to the
brain could produce subtle changes to our
visual-perceptual system, such as visual field
defects.
34What do each of these lobes do?
- Frontal Lobe- associated with reasoning,
planning, parts of speech, movement, emotions,
and problem solving - Parietal Lobe- associated with movement,
orientation, recognition, perception of stimuli - Occipital Lobe- associated with visual processing
- Temporal Lobe- associated with perception and
recognition of auditory stimuli, memory, and
speech
The senses of the body (speech, hearing,
feelings, seeing and memory) and control of the
muscles, are part of the grey matters function.
35TEMPORAL LOBES Located at sides of head above
ears, the temporal lobes form the wings of the
soul of our living caduceus. Functions The
dominant side is usually the left hand side and
governs- Hearing ability Understanding and
processing language Memory acquisition -
particularly long term memory Some visual
perceptions Categorization of objects. The no
dominant side or right side governs- Recognition
of facial expressions Decoding vocal intonation
Rhythm Music Visual learning
http//web-us.com/brain/braindominance.htm Left
vs. Right side brain test
How your memory works?
36- A deep furrow divides the cerebrum into two
halves, known as the left and right hemispheres.
Sometimes the right hemisphere is associated with
creativity and the left hemispheres is associated
with logic abilities. - The corpus callosum is a bundle of axons which
connects these two hemispheres.
The right hemisphere controls the left side of
the body, and the left hemisphere controls the
right side.
37Do Now!
- What are the 4 parts of the cerebrum?
- The convolutions of the cerebrum are comprised of
ridges and valleys. What are the ridges called?
The valleys? - What part of the brain is dedicated to visual
perceptions? - What part of the brain is associated with
reasoning, planning, parts of speech, movement,
emotions, and problem solving? - 5. What part of the brain is associated with
movement, orientation, recognition, perception of
stimuli? - 6. What part of the brain is associated with
perception and recognition of auditory stimuli,
memory, and speech? - 7. What is the deep furrow that divides the
cerebrum into two halves known as?
38The Cerebellum
- The cerebellum, or "little brain", is similar to
the cerebrum in that it has two hemispheres and
has a highly folded surface or cortex.
39CEREBELLUM Located at the base of the skull, and
attached to the rear of the brain stem.
Functions Coordination of voluntary
movement posture Balance and equilibrium Some
memory for reflex motor acts.
40Limbic System
- The limbic system, often referred to as the
"emotional brain", is found buried within the
cerebrum. Like the cerebellum, evolutionarily the
structure is rather old. - This system contains the
- thalamus (almost all sensory information enters
this structure where neurons send that
information to the overlying cortex ), - hypothalamus (functions including homeostasis,
emotion, thirst, hunger, circadian rhythms, and
control of the autonomic nervous system. In
addition, it controls the pituitary ) - amygdala (memory, emotion, and fear ),
- hippocampus (important for learning and memory,
for converting short term memory to more
permanent memory, and for recalling spatial
relationships in the world about us)
Sense of smell
41BRAIN STEM Located deep in the brain, leads to
spinal cord. Often referred to as The 'Reptilian'
or 'Primitive' Brain. The majority of the cranial
nerves exit from the brain stem at the
pons. Functions Breathing Heart Rate
Swallowing Reflexes to seeing and hearing
(Startle Response). Controls sweating, blood
pressure, digestion, temperature (Autonomic
Nervous System). Affects level of alertness.
Ability to sleep. Sense of balance (Vestibular
Function).
42Grey vs. White Matter
- Grey matter closely packed neuron cell bodies
(making up the cerebral cortex) form the grey
matter of the brain. The grey matter includes
regions of the brain involved in muscle control,
sensory perceptions, such as seeing and hearing,
memory, emotions and speech. - White matter neuronal tissue containing mainly
long, myelinated axons, is known as white
matter or the diencephalon. It makes up the
cerebrum. The color comes from the myelin. - The nuclei of the white matter are involved in
the relay of sensory information from the rest of
the body to the cerebral cortex, as well as in
the regulation of autonomic (unconscious)
functions such as body temperature, heart rate
and blood pressure. - Certain nuclei within the white matter are
involved in the expression of emotions, the
release of hormones from the pituitary gland, and
in the regulation of food and water intake. These
nuclei are generally considered part of the
limbic system.
43Brain stem 3 parts
- Lower animals have only a medulla.
- The brain stem controls the reflexes and
automatic functions (heart rate, blood pressure),
limb movements and visceral functions (digestion,
urination).
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45- Corpus callosum
- Cerebellum
- Pituitary gland
- Pons
- Medulla
- Spinal cord
- Frontal
- Temporal
- Occipital
- Parietal
Put answers on back of fill-in page
6.
1.
7.
8.
2.
3.
9.
4.
5.
10.
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4712 Cranial Nerves
48Fissure any cleft or groove, normal or
otherwise, especially a deep fold in the cerebral
cortex involving its entire thickness.
49Brains
- Wild pig, dolphin, human
- Chimpanzee?
50Sheep Brain Dissection Guide
http//www.wellesley.edu/Biology/Concepts/Html/she
epbrain.html http//academic.scranton.edu/departm
ent/psych/sheep/
51Dura mater
Superior ID
52After splitting the cerebral hemispheres
Part 1 Sheep brain dissection http//www.youtube.
com/watch?vy7gEWzPqm94
53Ventral side of the brain
Part 2 Brain dissection http//www.youtube.com/wa
tch?vjr3qSaUzc6Q
54Here's the cerebellum pushed downward to expose
the superior and inferior colliculi and pineal
gland
The Superior colliculus (2 parts) and the
inferior colliculus (2 parts) make up the corpora
quadrigemina. They are the reflex centers
involving hearing and vision.
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58The Nerves
The largest nerve in the body is the sciatic and
it splits into the common tibial and fibular
nerves that run down each leg.
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61How the messages travel
62PNS
- As part of the Peripheral Nervous System, nerves
reach from your brain to your face, ears, eyes,
nose, and spinal cord... and from the spinal cord
to the rest of your body. - Motor neurons (motoneurons) carry signals from
the central nervous system to the outer parts
(muscles, skin, glands) of your body. - Sensory neurons carry signals from the outer
parts of your body (periphery) into the central
nervous system. - Receptors sense the environment (chemicals,
light, sound, touch) and encode this information
into electrochemical messages that are
transmitted by sensory neurons. - Interneurons connect various neurons within the
brain and spinal cord.
63Reflex Pathways
- The simplest type of neural pathway is a
monosynaptic (single connection) reflex pathway,
like the knee-jerk reflex. - 1. When the doctor taps the right spot on your
knee with a rubber hammer, receptors send a
signal into the spinal cord through a sensory
neuron. - 2. The sensory neuron passes the message to a
motor neuron that controls your leg muscles.
Nerve impulses travel down the motor neuron and
stimulate the appropriate leg muscle to contract.
- 3. The response is a muscular jerk that happens
quickly and does not involve your brain. - Humans have lots of hard-wired reflexes like
this, but as tasks become more complex, the
pathway "circuitry" gets more complicated and the
brain gets involved.
64Revisiting the Knee-Jerk Response
- What is the stimulus?
- The hammer hits the tendon.
- The muscle contracts, causing the foot to jerk
upward. - What is the response?
- The muscle contracts, causing
- the foot to jerk upward.
65How is the Hammer Tap Detected?
- The muscles in your leg have stretch receptors.
- They react to a change in length of the muscle.
- When the hammer hits the tendon at the knee, it
- makes a muscle in the front of your thigh longer
- (stretches it).
- That stimulates the stretch receptors in that
muscle.
66Other Reflexes
Stimulus Response
An insect flying towards your eye Blinking
The aroma of your favorite food Salivation
A bright light shining in your eye Pupils get smaller
A nasty odor Nausea
67Whats a Reflex?
- You need to detect a change in the environment (a
stimulus) and react to the change (a response) in
a way that maintains homeostasis. - When you do this without thinking, it is called a
reflex.
68How is a Stimulus Detected?
- Some cells are specialized to react to a specific
stimulus. - These are called receptors (they receive a
stimulus). The receptor cells of your eyes are
stimulated by light.
69The Response
- When the receptor is stimulated, it sends a
message to a part of your body that effects the
correct response. - This is called the effector.
70Reflex arc
71How the Message Travels From the Receptor to the
Effector.
- A sensory neuron carries the message from the
receptor to the central nervous system (the
spinal cord and brain). - A motor neuron carries the message from the
central nervous system to the effector. - This is a reflex arc.
72Motor (efferent) Neurons
- Is divided into two groups
- 1. Autonomic system
- The ANS In most situations, we are unaware of the
workings of the ANS because it functions in an
involuntary, reflexive manner. - 2. Somatic system (back to this in a moment)
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74Name the Neurons
- Neuron 2 ?
- Sensory (Afferent) Neuron
75Name the Neurons
76Name the Neurons
- Neuron 4 ?
- Motor (Efferent) Neuron
77The ANS is most important in two situations
- In emergencies that cause stress and require us
to"fight" or take "flight" (run away) -
- In non-emergencies that allow us to "rest"
"digest." .
The ANS is divided into three parts 1. The
sympathetic nervous system 2. The
parasympathetic nervous system 3. The enteric
nervous system (is a meshwork of nerve fibers
that innervate the viscera (gastrointestinal
tract, pancreas, and gall bladder).
78ANS
- Parasympathetic
- This calls for "Rest and Digest" responses. Now
is the time for the parasympathetic nervous to
work to save energy - your blood pressure
decreases, your heart beats slower, and digestion
can start.
- Sympathetic
- These are "Fight or Flight" responses. In these
types of situations, your sympathetic nervous
system is called into action - it uses energy -
your blood pressure increases, your heart beats
faster, and digestion slows down.
79The Autonomic Nervous System The Autonomic Nervous System The Autonomic Nervous System
Structure Sympathetic Stimulation Parasympathetic Stimulation
Iris (eye muscle) Pupil dilation Pupil constriction
Salivary Glands Saliva production reduced Saliva production increased
Oral/Nasal Mucosa Mucus production reduced Mucus production increased
Heart Heart rate and force increased Heart rate and force decreased
Lung Bronchial muscle relaxed Bronchial muscle contracted
Stomach Peristalsis reduced Gastric juice secreted motility increased
Small Intestine Motility reduced Digestion increased
Large Intestine Motility reduced Secretions and motility increased
Liver Increased conversion ofglycogen to glucose
Kidney Decreased urine secretion Increased urine secretion
Adrenal medulla Norepinephrine andepinephrine secreted
Bladder Wall relaxedSphincter closed Wall contractedSphincter relaxed
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82- The inner part, the adrenal medulla, produces
catecholamines, such as epinephrine. - Also called adrenaline, epinephrine increases
blood pressure and heart rate when the body
experiences stress. - These hormones are produced in response to
stressors such as fright, anger, caffeine, or low
blood sugar. (Epinephrine injections are often
used to counteract a severe allergic reaction.)
Detailed epinephrine action Fight or
Flight http//www.youtube.com/watch?vejq99wLEMTw
featurerelated
83Flight or Flight Response Video
- http//www.youtube.com/watch?v4g25d7_Afmcfeature
related (from Discovery Channel 6 min.) - Adrenaline Rush Standing on a cliff
http//www.youtube.com/watch?vDplhL6mJhcQfeature
related - Adrenaline Rush Shark cage http//www.youtube.co
m/watch?v50dVhd4dmp8featurefvwrel
84Back to The Somatic Nervous System
- Somatic Nervous System
- The somatic nervous system consists of
peripheral nerve fibers that send sensory
information to the central nervous system AND
motor nerve fibers that project to skeletal
muscle. - The picture shows the somatic motor system. The
cell body is located in either the brain or
spinal cord and projects directly to a skeletal
muscle.
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86This very strange creature in the Glasgow Science
Centre is the Homunculus. The different parts of
the body are sized according to the amount of
nerves present in that part of the body.
87Disorders of the Nervous System
88Alzheimers disease
- progressive degenerative brain disease that
results in dementia associated with a shortage of
acetylcholine (an important neurotransmitter) and
structural changes in brain areas involving
cognition and memory. Because nerve cells do not
undergo mitosis, new cells can not be generated.
89Cerebrovascular accident (CVA)
- brain dysfunction where blood supply to a region
is blocked and vital brain tissues dies as by a
blood clot or ruptured blood vessel. This is
more commonly called a stroke.
http//www.webmd.com/stroke/ss/slideshow-stroke-ov
erview?ecdwnl_chl_100411
90Stroke Test Talk, Wave, Smile
- The F.A.S.T. test helps spot symptoms. It stands
for - Face. Ask for a smile. Does one side droop?
- Arms. When raised, does one side drift down?
- Speech. Can the person repeat a simple sentence?
Does he or she have trouble or slur words? - Time. Time is critical. Call 911 immediately if
any symptoms are present.
91Parkinsons Disease
- Parkinson disease (PD) is characterized by a
slowing of voluntary movements, bradykinesia
stone face, muscular rigidity and tremor at
rest. - These abnormalities result from a reduction of
neurons that make dopamine.
92Multiple sclerosis
- when the myelin sheath around the axon
deteriorates the electrical current is short
circuited. - The person may experience visual and speech
disturbances and also lose muscle control.
93M.S.
94Tourette Syndrome
- This syndrome begins in childhood and manifests
itself through various forms of tics. - These tics include frequent, irregular movements
of the head, neck, or shoulders. They also may
be more complex motor behaviors such as snorting,
sniffing, and involuntary vocalization. - As the syndrome progresses repetitive behaviors
such as touching others, obsessive compulsive
symptoms, and explosive involuntary cursing can
be more common. - Aggressive behavior and improper sexual impulses
are the rarest and most severe expressions of the
syndrome. - The cause of Tourette syndrome is not known, but
it is believed to have a genetic component.
95Famous People with Tourettes (OCD)
Dan Ackroyd was diagnosed with tourette's and
asperger syndromes at an early age, but the
symptoms seem to have disappeared when he was
around 14. The diagnosis of Asperger syndrome did
not exist in the 1960s, when Aykroyd was a
preteen. It involved mostly grunting and physical
tics through nervousness.
David suffers from OCD and it manifests itself
through constant cleanliness and perfection of
all that is around him. Anything out of order is
enough to cause a conflict and must be attended
to immediately. Examples of this complete order
is that everything must be in pairs, if there are
three books on a table one must be added, or one
must be removed. Only 2 of the population suffer
from this strong OCD.
- Wolfgang Amadeus Mozart - (1756-1791) It has
also been documented that he was hyperactive,
suffered from mood swings, had tics, and loved
made-up words. Despite these behaviors, we will
probably never know for certain whether Mozart
had TS.
96Cerebral Edema
- The brain reacts to severe head trauma by
retaining water. As a result, the brain swells.
The pressure grows as the brain presses on the
skull. This can be fatal or result in severe
brain damage.
97Famous People with Cerebral Edema
Actor Natasha Richardson
98Video The Secret Mind54 min
- http//video.google.com/videoplay?docid2661634191
857056612
99Nervous System Test
- Complete your study guide to prepare for the
test. - The test has.
- 29 multiple choice (2 pts each)
- 6 labeling neuron (2 points each)
- 10 fill in the blanks (2 pts each)
- 6 label parts of the brain
- 100 points