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Paludisme: Vaccin

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Title: PowerPoint Presentation Author: Patricia Baldacci Last modified by: Myrian Created Date: 9/18/2003 2:28:32 PM Document presentation format – PowerPoint PPT presentation

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Title: Paludisme: Vaccin


1
Paludisme Vaccin anti-maladie?
IFR 113 UMR-S 945 "Infections et Immunité"
  • Dominique Mazier

2
Lycett and Kafatos, Nature, 2002
3
Vaccin(s) érythrocytaires asexués1. Vaccin
 anti-parasite 
4
Vaccin(s) érythrocytaires asexués2. Vaccin
 anti-maladie 
Tenter de reproduire létat de prémunition
5
  • Prémunition
  • Immunité acquise
  • protection

incomplète labile lente
Au prix dune mortalité importante
6
(No Transcript)
7
(No Transcript)
8
Apoptose de la cellule endothéliale
9
Gabon patients presenting with malaria of
contrasting severity
Touré et al, 2007
10
Apoptogenic versus non apoptogenic isolates
11
  • Les AC contre ces facteurs de pathogénicité
  • sont ils protecteurs?

12
Modèles in vitro
Anticorps Parasites KO
13
P. falciparum in humanized mice
Moreno et al, Trends in Parasitol, 2006
14
No cerebral malaria!
15
Generation of a transgenic hICAM-1 mouse model
for the study of P. falciparum sequestration
severe malaria
16
hICAM-1 / bEnd5 P. falciparum iRBC
17
Basis of a vaccine that could target clinical
severity?
Passive transfert?Attenuated strains?
18
(No Transcript)
19
?
20
Cytoadhérence
Nécessaire
Pas suffisante
Conséquences de la cytoadhérence
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