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1
Studies in monkeys, and later in humans,
demonstrated that treatment (Rx) of
hypercholesterolemia with diet (in monkeys) or
statins (in humans) produces a rapid, profound
reduction in LDL. Hypercholesterolemia produces
gradual progression of structural changes
(ASatherosclerosis), and atherosclerotic plaque,
and treatment produces only modest structural
improvement (Rregression)
Donald D. Heistad, ATVB 200626689-695
2
ECSOD is synthesized and released from smooth
muscle cells, but not endothelium
Donald D. Heistad, ATVB 200626689-695
3
Some heparin-binding proteins
Donald D. Heistad, ATVB 200626689-695