??? ???(ribosome)

1
??? ????
1?????
????????????????,????????????????,????????(occludi
n and claudins)??????????????????(????)
2?????
??????? ???????????????????????????,
????????????????????-?????????????,???????????????
? ???????? ??????????????,??????????????,?????
?????????????????????????????(???????)
2
????????
3
?????????
4
???????
5
??????
6
????????
7
??????????????
8
????????
9
???????
?????
10
???????????
??????
11
3?????
????? ?????????????,?6????????????????,????1.
5nm???,??????????,????? ????????????????????
?????????????????????????????? ?????
????????????,????,??????????????,???????? ?????
??????????????,???????????????
12
????
13
??????
14
????
15
??????
16
????????
??????
17
(No Transcript)
18
???????
19
4??????????
(????????????????????????)
???????????????????????????
?????(Integrin) ????????(Immunoglobulin
superfamily) ????????(Cadherin) ??????(Syndecans)
?????(Selectin)
20
???????
21
?????
22
????????????
23
???????
24
???????????
P-selectin
E-selectin
L-selectin
25
(No Transcript)
26
??????????????
300 kb
Chromosome 1
P-selectin
L-selectin
E-selectin
Plateletes Endothelia cells
Leukocyte
Endothelia cells
active
gene
Cycloheximide
Actomycin D
Thrombin, Histamine ???C????, ??????
Activating
IL-1, TNF-a, LPS
IL-1, TNF-a, LPS
27
??????????
28
Selectin and their ligands
PSGL-1 GlyCAM-1 CD34 MadCAM-1 Sgp200 Human
podocalyxin-like protein Sialyl 6-sulfo Lewis
X E-selectin
L-selectin
PSGL-1 Sialyl 6-sulfo Lewis X CD24/HAS(heat
stable antigen)
P-selectin
PSGL-1 Sialyl 6-sulfo Lewis X ESL-1 CD44 L-selecti
n
E-selectin
29
????????
30
??? ??????????
????(??)????????????(??????) ???????????,?????????
?????????
1???
????????30??,??????????????,??I-IV?,????????????
??????????? ???????-???????????-???? ???????????
?,???????????,?????,??????? ????????????,????????
????????,??????????
31
????????
32
????????????
33
(No Transcript)
34
2??????????(?????)
???? ???????(????????)??????????????,?????,?????
?,??,?????? ??????????????????????????????
3????????????
????? ?????????????????????,???????????????? ????
????????,????,20???,?????????,??????,???????
35
???????
36
????(A,B)?????(C)????????(D)
37
????????
38
???????
39
??????????
40
FN????????
41
????
42
????????