Glc

1
The Liver
Glc
Glc
Glc ? Glc6P ?? glycogen ?G1P ?G6P ?Glc
Glycerol Lactate Alanine
Glycerol Lactate Alanine
Glycolysis Krebs
OUT
Fatty Acids (Diet)
Fatty Acids
VLDL (chol, TAG)
VLDL (chol, TAG)
IN
Fatty Acids (adipose)
Fatty Acids (adipose)
ketone bodies
ketone bodies
AcetylCoA
Glucogenic Ala,Ser, Cys Gly, Thr, Trp
Other glucogenic AA
Pyruvate
Amino Acids
Amino Acids
Arg, Gln, Glu, Pro, His to aKG Ile, Met, Val to
succCoA Asp, Phe, Tyr to fumarate Asp, Arg to OAA
Ketogenic Ile, Leu, Thr, Trp (Leu, Lys, Phe,
Tyr?AcAc
AcetyCoA
AA1 aKG ? OAA Glu