Title: EUROPA
1Baseline characteristics
2Patient flow
3424 centres 12 218 patients
4Not randomised
5Baseline characteristics
Perindopril (mean ? SD) Placebo (mean ? SD)
Age (yrs) 60 ? 9 60 ? 9
Male () 86 85
Weight (kg) 81 ? 12 80 ? 12
HR (bpm) 68 ? 10 68 ? 10
SBP (mmHg) 137 ? 16 137 ? 15
DBP (mmHg) 82 ? 8 82 ? 8
6Medical history
Perindopril () Placebo ()
Myocardial infarction 64.9 64.7
Revascularisation 54.7 55.2
Stroke / TIA 3.4 3.3
Heart failure 1.3 1.2
Peripheral vascular disease 7.1 7.4
7Risk factors
Perindopril () Perindopril () Placebo ()
Hypertension Hypertension 27.0 27.2
Diabetes mellitus Diabetes mellitus 11.8 12.8
Hypercholesterolaemia Hypercholesterolaemia 63.3 63.3
Current smoker Current smoker 15.4 15.1
8Baseline medication
Perindopril () Placebo ()
Platelet inhibitors 91.9 92.7
?-blockers 62.0 61.3
Lipid lowering drugs 57.8 57.3
Nitrates 42.8 43.0
Ca-blockers 31.7 31.0
Diuretics 9.1 9.4
Oral anticoagulants 4.4 4.2
9Results
10Primary endpoint
CV death, MI or cardiac arrest
Placebo
Perindopril
Years
Placebo annual event rate 2.4
11Primary and first secondary endpoint
12Sub-groups analysis
13Sub-groups analysis
14Sub-groups analysis
92 patients on platelet inhibitors
15Secondary endpoints
16Fatal and non fatal MI
()
Placebo
Perindopril
17Hospitalisation for heart failure
Placebo
Perindopril
18Blood pressure
?SBP 5 mmHg ?DBP 2 mmHg
19Adherence to treatment
20Withdrawal from treatment
Perindopril Placebo
Cough 2.7 0.5
Hypotension 1.0 0.3
Kidney failure 0.3 0.3
Intolerance 2.4 1.3
Study end-point 6.2 7.5
Hypertension 0.4 0.8
Refuse to continue 4.3 4.2
Other reason 5.7 5.8