Characterization of polymicrobial infections and risk assessment among keratitis patients

1
Characterization of polymicrobial infections and
risk assessment among keratitis patients

• Denise de Freitas, Fabio Carvalho, Pedro Ferrari,
  Maria Flávia Ribeiro, Annette Foronda, Ana Luisa
  Hofling-Lima

Department of Ophthalmology, Federal University
of Sao Paulo
The authors have no financial interest in the
subject matter of this poster.
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Purposes

• To report bacterial and fungal co-infection in
  Acanthamoeba keratitis
• To investigate the risk assessment associated
  with polymicrobial infection

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Methods

• Retrospective analysis of the records
• Clinical and laboratorial diagnoses
• Patients with microbial keratitis
• Period January, 1998 June, 2009

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Results

• 65 polymicrobial keratitis patients
• AK and bacterial keratitis 61 patients
• AK and fungal keratitis 4 patients
• Occurrence of microbial co-infection among
  contact-lens wearers
• 66 of investigated patients

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Results

• Polymicrobial keratitis Acanthamoeba/ Bacteria

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Results

• Polymicrobial keratitis
• Acanthamoeba/ Coagulase-negative staphylococci
  bacteria 74

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Results

• Polymicrobial keratitis
• Acanthamoeba/ Bacteria and contact-lens wearers
  69

8
Results

• Polymicrobial keratitis
• Acanthamoeba and fungus
• 3 molds
• 1 yeast

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Conclusions

• Contact-lens wearers are the main risk group for
  polymicrobial keratitis
• The occurrence of microbial co-infection among
  keratitis patients could be an enhancer for
  disease severity

10
Conclusions

• Contact-lenses wear associated with inadequate
  lens disinfection and microbial co-infection have
  to be considered as important prognostic tools
  related with cornea and external disease.