SAN FRANCISCO EAST BAY AUTISM/ASPERGERS CONFERENCE

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SAN FRANCISCO EAST BAY AUTISM/ASPERGERS
CONFERENCE

• DECEMBER 1-2, 2006
• ALAMEDA COUNTY FAIRGROUNDS
• PLEASANTON, CA

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OVERVIEW BIOMEDICAL TESTING AND
TREATMENT OF AUTISM Jaquelyn
McCandless, M.D.

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SUMMARY DAN! ASD BIO-MEDICAL TREATMENTS

• 1) DIETARY RESTRICTION
• 2) NUTRIENT THERAPY
• 3) GUT PATHOGEN TREATMENT
• 4) METHYLATION STRATEGIES
• 5) DETOXIFICATION (CHELATION)
• 6) IMMUNE ENHANCEMENT
• 7) ANTI-VIRAL TREATMENT
• 8) HBOT, NEUROFEEDBACK

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WORLDWIDE ASD EPIDEMIC

• FROM 2001-04, 1026 INCREASE IN FULL-DIAGNOSIS
  ASD SCHOOL AGE CHILDREN PER US DEPT OF EDUCATION.
  
• OVER 2 MILLION CHILDREN IN US HAVE ASD, OVER 6
  MILLION HAVE ADD/ADHD, OVER 2 MILLION TAKE
  RITALIN
• INCIDENCE OF CLASSIC 110,000 TO ACQUIRED
  (REGRESSIVE) ASD 1150
• RATIO - BOUSGIRLS 41 for ASD, ADD/ADHD,
  LEARNING/BEHAVIOR

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AUTISM (ASD) CHARACTERISTICS

• AUTISM SPECTRUM INCLUDES
• AUTISM, HFA, ASPERGERS, PDD, ADD/ADHD
• ? FAILURE TO BOND
• ? LACK OF SOCIAL INTERACTION
• ? AVOIDANCE OF EYE-TO-EYE CONTACT
• ? DIFFICULTIES IN LANGUAGE DEVELOPMENT
• ? REPETITIVE BEHAVIORS CALLED STIMMING

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ASD BIO-MEDICALLY

• GENETIC PREDISPOSITION ALLERGIES, AUTOIMMUNITY,
  FAMILY HISTORY
• WEAKENED IMMUNE SYSTEM, FREQUENT
  INFECTIONS/ANTIBIOTICS 1st YEAR
• GUT INFLAMMATION, PATHOGENS
• IMPAIRED NUTRITIONAL STATUS INABILITY TO
  EXCRETE THEREFORE ACCUMULATE HEAVY METALS IN
  THEIR BODIES

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BASIC EVALUATION

• HISTORY, PHYSICAL EXAM
• BASIC GENERAL LAB SCREEN
• CBC, URINALYSIS
• SERUM CHEMISTRIES
• THYROID PANEL
• IRON PANEL

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BASIC DIAGNOSTIC TESTS

• FOR GUT
• URINE ORGANIC ACIDS
• COMPREHENSIVE STOOL STUDY
• FOR NUTRIENT STATUS
• ORGANIC ACIDS, AMINO ACIDS
• RBC MINERALS, FATTY ACIDS VITAMIN PANEL

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CLINICAL HISTORY EARLY INDICATIONS OF GUT
DYSFUNCTION

• 1) FAMILIAL DIGESTIVE DIGESTIVE DYSFUNCTIONS
• 2) INABILITY TO BREAST FEED
• 3) PERSISTENT COLIC IN INFANCY
• 4) FREQUENT INFECTIONS (E.G. EAR) LEADING
  TO FREQUENT ANTIBIOTICS
• 5) REACTION TO CERTAIN VACCINATIONS

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GASTROINTESTINAL PATHOLOGY SYMPTOMS REPORTED
BY PARENTS

• PERSISTENT DIARRHEA AND/OR CONSTIPATION,
  BLOATING, GAS AND ABDOMINAL PAIN
• SELF-RESTRICTION OF DIET
• NIGHT WAKING REFLUX
• GREATER ALLERGIC SUSCEPTIBILITIES

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G.I. HEALTH TREATMENTS PARENTS CAN DO

• ELIMINATE SUGARS AND JUNK FOOD FOR EVERYONE IN
  THE FAMILY
• READ LABELS ON FOODS, GET EDUCATED ABOUT TOXINS
  IN BOTH FOOD AND WATER
• GF/CF/SF OR SCD DIET
• ENZYMES AND PROBIOTICS
• BASIC NUTRIENT SUPPLEMENTATION

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G.I. HEALING TREATMENTS THAT REQUIRE A PHYSICIAN

• LAB TESTING FOR GUT PATHOGENS
• ANTI-FUNGAL PRESCRIPTIONS RX
• ANTI-BACTERIAL PRESCRIPTION RX (CLOSTRIDICA AND
  OTHER)
• SECRETIN, VIT M-B12 INJECTABLES
• IMMUNOGLOBULIN, IV OR ORAL, ENDOSCOPY

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METABOLIC IMBALANCES IN AUTISM SPECTRUM DISORDER

• MULTIPLE NUTRITIONAL DEFICIENCIES
• ELEVATED IgG ANTIBODIES GLUTEN/CASEIN
• IMBALANCE GUT BACTERIAL FLORA
• URINE BACTERIAL/FUNGAL BYPRODUCTS
• MYELIN SHEATH INJURY IN BRAIN
• EVIDENCE OF IMMUNE IMPAIRMENTS
• METHYLATION DISORDERS
• INABILITY TO EXCRETE TOXINS/METALS

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ASD CAUSATION MODELS

• 1) SIMPLY GENETIC?
• 2) GUT HEALTH MEASLES, GLUTEN/CASEIN
  INTOLERANCE, ENZYME DEFICIENCY, FUNGAL
  OVERGROWTH MODEL
• 3) TOXIC CHEMICALS/HEAVY METALS VACCINATIONS,
  AMALGAMS/FISH
• 4) AUTOIMMUNITY, VIRAL MODEL

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GENETICS AS CAUSE?

• RESEARCH HAS BEEN UNABLE TO IDENTIFY A SPECIFIC
  CHROMOSOME OR LOCATION ON A GENE THAT IS THE SITE
  OF A PRIMARY AUTISM DEFECT.
• GENETIC SUSCEPTIBILITY PROBABLE

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GUT HEALTH TREATMENTS THAT PARENTS CAN DO

• ELIMINATE SUGARS AND JUNK FOOD FOR EVERYONE IN
  FAMILY
• READ LABELS ON FOODS, GET EDUCATED ABOUT TOXINS
  IN BOTH FOOD AND WATER
• GF/CF/SCD DIET
• ENZYMES AND PROBIOTICS
• BASIC NUTRIENT SUPPLEMENTATION

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GUT HEALTH TREATMENTS THAT REQUIRE A DOCTOR

• LAB TESTING FOR GUT PATHOGENS
• ANTI-FUNGAL PRESCRIPTIONS
• ANTI-BACTERIAL PRESCRIPTIONS (FOR CLOSTRIDIA AND
  OTHERS)
• SECRETIN, VIT M-B12 INJECTIONS
• IMMUNOGLOBULIN, IV OR ORAL
• ENDOSCOPY-ANTI-INFLAMMATORIES

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WAKEFIELD INFLAMMATORY BOWEL DISEASE IN AUTISM

• GUT BIOPSIES, 1998 MEASLES VIRUS DETECTED IN
  DENDRITIC CELLS AND MATURE LYMPHOCYTES IN 75/91
  ASD CHILDREN VS 5/70 CONTROLS WITH LYMPHOID
  NODULAR HYPERPLAXIA
• NEW 2006 BUIE, KRIGSMAN VALIDATE WAKEFIELDS
  FINDINGS INCREASED GI INFLAMMATION IN ASDS WITH
  87 BIOPSIES SHOWING VACCINE STRAIN MEASLES IN
  GUT

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GUT MEASLES ASSESSMENT

• HISTORY, MMR RESPONSE
• GUT ISSUES
• RUBEOLA ANTIBODIES TEST
• BRAIN AUTO-ANTIBODIES TEST
• ENDOSCOPY
• BIOPSY, CSF ANALYSIS
• PCR (POLMERASE CHAIN)

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MEASLES AND BRAIN VIRAL AUTO-ANTIBODIES IN ASD

• SINGH 1998 70 OF AUTISTIC SERA HAD ANTI-MYELIN
  BASIC PROTEIN ANTIBODIES, NONE IN NT CHILDREN.
• 57 ASD HAD ANTI-NEURON-AXON FILAMENT PROTEIN,
  NONE IN NT KIDS
• HIGHER ANTI-MEASLES ABS THAN NT KIDS, MUMPS AND
  RUBELLA NOT DIFFERENT FROM NTS

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GUT MEASLES TREATMENT

• DIETARY RESTRICTION
• ENZYMES
• GENERAL IMMUNE ENHANCEMENT
• METHYLATION
• DECREASE HEAVY METALS
• HEAL LEAKY GUT
• ANTI-OXIDANTS
• LIVER SUPPORT
• ANTI-INFLAMMATORIES
• HIGH DOSE VIT A PROTOCOL

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HIGH-DOSE VITAMIN A FOR GUT MEASLES

• BAKER - McCANDLESS PROTOCOL
• 200,000-400,000IU ORAL 2 DAYS EVERY SIX MONTHS
  IF 3 OF 5 POSITIVE
• 1) HISTORY OF REGRESSION AFTER MMR
• 2) PERSISTENT GUT PROBLEMS, PAIN
• 3) MORE THAN SLIGHTLY ELEVATED IgG SERUM RUBEOLA
  ABS
• 4) ELEVATED ANTI-MBP ANTI-NF ABS
• 5) ENDOSCOPY SHOWS ILH, CSF/BIOPSY, PCR VACCINE
  STRAIN MEASLES

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ANTI-FUNGAL PRESCRIPTIONS (BASED on 40-50
CHILD)

• DIFLUCAN (FLUCONAZOLE - PRIMARY ONE I USE)
• 4-5mg/kg/day for 3-4 weeks in divided doses
• NIZORAL (ITROCONAZOLE -GOOD FOR LOWERING
  TESTOSTERONE)
• 5mg/kg/day for 3 weeks in divided doses
• SPORANOX (USE WHEN RESISTANCE TO FLUCONAZOLE)
• 75-100mg/day for 3-4 weeks
• NYSTATIN (TOPICAL MANY YEAST OUTGROW), BENIGN
  INEXPENSIVE
• 250,000 units qid
•  

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ANTI-BACTERIAL PRESCRIPTIONS (Based on 50 child)

• FLAGYL (clostridia, parasites) 250mg BID for 10
  days
• BIAXIN 125mg/BID (tonsillitis, sinusitis)
• GENTAMYCIN 40-80mg BID for 10 days
• VANCOMYCIN 1 gram/day in 1/4 gm QID doses 5-10
  days
•  

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NEUTRACEUTICAL COMPANIES I USE MOST FREQUENTLY
(U.S.)

• ECOLOGICAL FORMULAS 800-888-4585
• KLAIRE LABS
  866-216-6127
• INTEGRATIVE THERAPEUTICS, INC.
• (NF FORMULAS/TYLER) 503-582-8386
• THORNE RESEARCH 800-228-1966
• VITAMIN RESEARCH 800-877-2447
• KIRKMAN LABS 877-365-9265
• PHYSIOLOGICS 800-765-6775

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SUMMARY RX GUT DISORDER

• RESTRICTIVE GF/CF/SF DIET, PROBIOTICS
• REMOVE OFFENDING FOODS PER IGG HYPERSENSTITIVITY
  TESTING
• REPLACE NUTRIENT DEFICIENCIES, ENZYMES
• TREAT FOR PATHOGEN OVERGROWTH
• WITH NATURAL PRESCRIPTIVE ANTI-FUNGALS,
  BACTERIALS

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TREATMENTS BEYOND THE BASICS

• TRIO
• 1) GLUTATHIONE, TD-ORAL-IV
• 2) TTFD (ALLITHIAMINE AUTHIA)
• 3) M-B12 SUBCUT INJECTIONS
• QUARTET
• 4) ADD FOLINIC ACID

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METHYLCOBALAMIN

• VIT B12 LEAST TOXIC, BEST TOLERATED
• UPTAKE FROM ORAL INTAKE LOW, PARTICULARLY IN
  GI INFLAMMATION.
• VIT B12 PLAYS KEY ROLE IN GSH STABILIZATION
  REDUCTION STATUS FOR ENDOGENOUS ANTIOXIDANTS
• DIFFICULT TO TEST FOR DEFICIENCY
• ULTRA HIGH DOSES MAY REGENERATE NERVES

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GLUTATHIONE (GSH)

• NATURALLY OCCURING TRI-PEPTIDE FROM CYSTEINE,
  GLUTATMIC ACID, GLYCINE
• PRESENT IN ALL LIVING CELLS,
• HIGHEST LEVEL FOUND IN LIVER
• INHIBITS FORMATION OF FREE RADICALS
• DETOXIFIES HARMFUL COMPOUNDS.
• DEFICIENCY INCREASES SENSITIVITY
• TO THIMEROSAL AND OTHER
• PRO-OXIDANT AGENTS.

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GLUTATHIONE, Contd.

• ENHANCE GSH LEVELS BY HELPING BODY
  MANUFACTURE IT
• VIT C, E, A-LIPOIC ACID (ALA), N-ACETYL CYSTEINE
  (NAC), SELENIUM, GLUTAMINE, AND SILYMARIN
• VITAMIN B12 HELPS MAINTAIN GLUTATHIONE IN ITS
  USEFUL REDUCED BIOLOGICAL STATE.

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TTFD (ALLITHIAMINE)

• TTFD THIAMINE TETRAHYDROFURFURL DISULFIDE,
  SYNTHETIC COUNTERPART TO ALLITHIAMINE, DERIVATIVE
  VIT B1 (THIAMINE), FOUND IN GARLIC.
• THIAMINE WATER-SOLUBLE, REQUIRED METABOLISM
  PROTEINS, CARBS, FATS
• THIAMINE DEFICIENCY IN ALCOHOLISM, MALNUTRITION,
  USE OF CERTAIN DRUGS

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TTFD, CONTD

• GENTLE CHELATOR FOR ARSENIC, CADMIUM, ALUMINUM,
  LESS FOR HG
• NON-TOXIC, NO PRESCRIPTION NEEDED, TRANSDERMAL
  CREAM TWICE DAILY

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TRIO QUINTET DOSES

• 1) GLUTATHIONE (GSH)
• 150 MG BID ORAL, 125 MB BID TRANSDERMAL,
  300-600MG IV WEEKLY
• OR BI-WEEKLY OR MONTHLY
• 2) ALLITHIAMINE (TD-TTFD)
• 50 MG 2X DAILY (COMPOUNDED
• OR AUTHIA)
• 3) METHYLCOBALAMIN (INJECTABLE M-B12) CONC
  25-MG/ML, 64.5 MCG/KG 2X/WEEK
• 4) FOLINIC ACID, 400-MCG TWICE DAILY

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TOXICITY

• TOXIC CHEMICALS
• HEAVY METALS
• GLUTATHIONE
• VACCINATIONS
• AMALGAMS, FISH INGESTION

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DETOXIFICATION OF HEAVY METALS

• DMSAORAL, TD, NEW - SUPPOSITORIES
• DMPSORAL, TD, IV
• CaEDTA--- IV, SUPPOSITORY
• TTFD (AUTHIA) - TD

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VIRAL-IMMUNE ISSUES IN AUTISM

• EVIDENCE OF EFFECTS OF PSYCHOTROPIC VIRUSES IN
  AUTISM OTHER DEVELOPMENTAL DELAY DISORDERS
• POSITIVE RESPONSES TO ANTI-VIRAL TREATMENTS IN
  AUTISM

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HEALTHY IMMUNITY

• BALANCE BETWEEN Th1 - Th2, SWITCHES BACK AND
  FORTH AS NEEDED
• INABILITY TO RESPOND ADEQUATELY TO Th1 CHRONIC
  INFECTION CANCER
• OVERACTIVE Th2 RESPONSE PLAYS ROLE IN
  AUTOIMMUNITY AND ALLERGIES

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UNHEALTHY IMMUNITY

• FAILURE OF THE Th1 ARM OVERACTIVE Th2 ARM
• AIDS, CANCER
• CFS (FATIGUE)
• CANDIDIASIS
• MULTIPLE ALLERGIES
• MCS (CHEMICAL)
• AUTISM

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Th1/Th2 BALANCE

• Th1 CELLULAR IMMUNITY, DIRECTS NK T-CELLS AND
  MACROPHAGES TO ATTACK ABNORMAL CELLS AND
  PATHOGENS INSIDE THE CELL
• Th2- HUMORAL IMMUNITY, CREATES ANTIBODIES TO
  NEUTRALIZE FOREIGN INVADERS OUTSIDE CELL

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IMMUNE-ENHANCING

• OMEGA-3 FATTYACIDS
• GLUTATHIONE
• METHYLCOBALAMIN/FOLINIC
• DIETARY RESTRICTION
• PROBIOTICS
• VITAMIN C, E, A, CO-Q-10
• ANTI-FUNGALS
• ANTI-VIRALS

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NATURAL ANTI-VIRALS

• LAURICIDIN (ENVELOPED VIRUSES)
• GARLIC, OLIVE LEAF EXTRACT
• GLUTAMINE, PROBIOTICS
• BLACK ELDERBERRY
• OIL OF OREGANO
• IP- 6 (INOSITOL HEXAPHOSPHATE)
• GRAPEFRUIT SEED EXTRACT
• PROTEASE ENZYMES (VIRASTOP)
• HEALTHY LIFE STYLE

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ANTI-VIRAL PRESCRIPTIVES

• GENERAL IMMUNITY
• ORAL, IM, IV IMMUNOGLOBULINS
• LOW-DOSE NALTREXONE
• ACTOS
• ANTI-VIRALS
• VALTREX (PRIMARY ONE I USE)
• FAMVIR
• ACYCLOVIR FOR SMALL CHILDREN

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LIFE-STYLE ANTI-VIRAL MESSAGES

• EAT LOTS OF FRESH VEGETABLES
• DONT SMOKE
• GET ENOUGH SLEEP
• DONT EAT JUNK FOOD
• DONT DRINK TOO MUCH ALCOHOL
• NURTURE YOUR RELATIONSHIPS
• DO WORK YOU BELIEVE IN
• LAUGH AT YOURSELF
• IF VACCINATE, GET HG-FREE!!!!

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SUMMARY DAN! ASD BIO-MEDICAL TREATMENTS

• 1) DIETARY RESTRICTION
• 2) NUTRIENT THERAPY
• 3) GUT PATHOGEN TREATMENT
• 4) METHYLATION STRATEGIES
• 5) DETOXIFICATION (CHELATION)
• 6) IMMUNE ENHANCEMENT
• 7) ANTI-VIRAL TREATMENT
• 8) HBOT, NEUROFEEDBACK