Oncogenes, Anti-oncogenes

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? ? ? ?

• ????????
• ?????
• Oncogenes, Anti-oncogenes
• and Growth Factors

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? ? ? ? ? ?Oncogenes
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???(oncogene) ???????????????,???????????,????????
?
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???(oncogene)??? ???,????????,????????????,?
?????? ???(oncogene)????? ??????????????,?myc?
ras?erb?
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???????
?????(virus oncogene,v-onc) ?????????????,????????
???,??????????,???????????
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???????
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???????

• ?????(cellular-oncogene, c-onc)
• ????????????????????????(cellular-oncogene,
  c-onc)?????? (proto-oncogenes , pro-onc) ?

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• ????????
• ?????????
• ????????
• ?????????????
• ????,????????????

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• ????????????

??????????????????????? 1. src?? ??????? 2.
ras?? P21(?G??) 3. myc?? ??DNA???? 4.
sis?? P28(??????????) 5. myb?? ??????
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??????????
(?)????????? (?)???? (?)?????? (?)???
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• ????????
• ???????????
• ????????????

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(?)??????? sis---P28 (?)????????? c-src?c-abl?c
-mos ?c-raf (?)???????? c-src?c-abl?c-ras?c-mas?H-
ras?K-ras?N-ras?crk (?)?????? myc?fos
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? ? ?? ? ? ?Anti-oncogenes
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???????????
????(cancer suppressive gene, tumor suppressor
gene, anti-oncogene) ???????????????????????
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??????
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?????????
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???????????
(?)?????????(Rb??)
G0 G1?
DNA
S?
E-2F
DNA
mRNA
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(?)P53?????? 1?P53???
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2?P53?????
????A
P53??
DNA??
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P53??
P53??
P21??
???
?????G1?
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? ? ?? ? ? ?Growth factors
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????
????(growth factor) ?????????????,??????????,????
????????????
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???? ??? (endocrine) ??? (paracrine) ???
(autocrine)
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(No Transcript)
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????????
???????
???? ?????,??????
???????????
??????
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(No Transcript)
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?????????
(?)????
???? (apoptosis)
??????????,??????? ????????????????????
???????p53?? ???????p53?? ??????(NGF)
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(?)?????
1. ?????? myc?fos??????????? p53??????
2. ?????? PDGF????
3. ???? ras?myb?myc?fos?????IGF?TGF?FGF
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• 1???????????????????????????????????????????????
  ????????????????????????????
• 2????????????????????????Rb?P53??????
• 3????????????????????????????????????

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???

• 1???????????????????????????????????????????(LTR)
  
• 2?????????????????????????????????????????????????
  ?????????????Rb?P53???????????????????????????????
  
• 3??????????????????????????????????