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n.s. n.s. n.s. n.s. n.s.
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6.11 5.72 30.47 84.00 13.79
plt0.01 plt0.01 n.s. n.s. n.s.
13.00 13.69 35.15 88.7 14.62
15
???????55???oxy-Hb????????????
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1998?4?2001?9???????????????????
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26
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27
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28
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29
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31
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0
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40
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70
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90
100

(Kessler RC et al.,Arch Gen Psychiatry 2006
63415)
32
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33

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34
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35
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(1)????? (7)???? (2)??? (8)????? (3)?????
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??? (6)???
36
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?????(6.82.4)
(N94)
37
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(N94)
38
??????????(1)
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39
?????????????

• ADF ??????????Angstanfalle????????????????????????
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• ????????ADF????????
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40
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41
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  ?????????????????

42
(No Transcript)
43
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44
   ?????????????

???1??24??????????????????1?????25????????????1?????????????????????25????????????????????????????1?24????????24????????????????????25??1???1??????24???1??????????????????????????????????????????????????????????????????????????????1??????????????????????????????????????38?????????????????????????????????????????????????????????14????????????????????????????????????????????????????????????????1???????????????????????

www.creativehealth.jp/pages/lib/w3000298.html
45
??????????
www.creativehealth.jp/pages/lib/w3000298.html
46
????????????

• Eleven panic patients concentrations of
  melatonin were significantly lower than controls
  at 10 p.m. and midnight. At 9 p.m. and 11 p.m.,
  the concentrations were also nonsignificantly
  lower. (McIntyre IM et al J Affect Disord, 1987
  , 12203)
• Seven panic patients had significantly greater
  melatonin concentrations from 400 a.m. to 700
  a.m. than the control subjects. (McIntyre IM et
  al Am J Psychiatry,1990 , 147 462)

47
????
48
??????????????????????????????
???24?????????????????????????????????????????????
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www.kodomo-seikatsusyukan-tokyo.jp/important.html
49

?????????? (1)


???????????? ?????????????
??????????????????????????????????????????????! ?????????????????????????????


www.creativehealth.jp/pages/lib/w3000298.html
50
??????????(2)

????????????????
????????????????????????????????????????????????????
www.creativehealth.jp/pages/lib/w3000298.html
51
??????????(3)

??????????????
??????????!??????????????24??????????????????????????25??????????????????????????????????????????????
www.creativehealth.jp/pages/lib/w3000298.html
52
??????????(4)

?????????????
????????????????????1??????????????
www.creativehealth.jp/pages/lib/w3000298.html
53
?????????

• ????????????????????????????????????????(Broocks??
  1997)
• 10????????????????????????????????????????????????
  ????????(Meyer ?1999)
• ??????10??????????????????????????????????????????
  ?????????????????????????????????(Broocks??1998)

54
?????????
www.uniurb.it/Fisiologia/.../ MainResNeurogenesis
.htm
55
?????????????????

• ??.?????????????????5-HT(2C)??????
• ??????? brain-derived neurotrophic factor
  (BDNF)????????

Broocks A, et al Psychiatr Prax. 2007 Sep34
Suppl 3S300
56
???????????


75.512.30
69.09.10
40.89.05
39.38.75
SDS50???
SDS30???
????20-100?
Multiple Fatigue Inventry-20
plt.05, plt.01
57
Panic disorder among patients with chronic
fatigue.Manu P, Matthews DA, Lane TJ. South
Med J. 1991 Apr84(4)451-6.

• Department of Medicine, University of Connecticut
  School of Medicine, Farmington 06032.Among 200
  adults with a chief complaint of chronic fatigue
  evaluated in an internal medicine practice,
  currently active panic disorder was diagnosed in
  26 patients (13), a frequency tenfold greater
  than that in the general population. Panic
  disorder preceded or was coincidental with the
  onset of chronic fatigue in 21 of these patients.
  In comparison with the rest of the study cohort,
  significantly more patients with panic disorder
  had a history of severe depression, including
  persistent thoughts of death or suicide.
  Moreover, more patients with panic disorder
  showed a lifetime tendency to have physical
  symptoms that remained unexplained after medical
  evaluation. Our findings suggest that treatable
  panic disorder is an important contributor not
  only to major depression and somatization, but
  also to the etiology and clinical presentation of
  chronic fatigue in patients in an outpatient
  practice.
•  

???????????????13?????????????
58
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59
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60
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61
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62
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63
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64
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65
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66
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67
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68
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69
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70
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71
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72
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Anger Attack(????) ?????? ??????
?????????? ??????(???) ????? ?? ????(??)
73
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74
???????????????? ?????? 52ch NIRS??(????????)
75
???????NIRS ?????????????
???????
??(-)
??()
30 30.43 5.70 10.22 6.22 41.4314.10 12.87
4.67
18 32.615.09 8.225.42 31.948.03 14.943.23
??(?)
n.s. n.s. plt0.01 n.s.
??(?)
PDSS-J
SDS
????(?)
76
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?????(??31?)
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77
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78
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79
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80
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83
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84
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85
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