Corporate EHS Strategic Perspective

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Corporate EHS Strategic Perspective

• Michael Rottas
• Associate Director, Environmental Health Safety
• Pfizer Global RD Groton/New London Laboratories

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• Pfizer is the largest pharmaceutical company in
  the world.
• Human health
• Consumer health care
• Animal health
• 120,000 employees worldwide
• Operations in 150 countries
• Largest privately funded research organization in
  the world.
• Now 8 billion/year
• Groton Labs 1.5 billion/year

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• Global Environmental Management Initiative (GEMI)
  member
• UN Global Compact member
• EPA Climate Leaders participant
• Public Environmental Goals
• Reduce CO2 emissions by 35 by 2007 (2000 as
  baseline)
• 35 of global electricity needs by 2010 from
  clean sources
• Phase out of Class I ODCs by 12/31/2005

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Where we were

• EHS professionals, in Corporate setting, were
  necessary overhead due to compliance requirements
  
• Outsiders from manufacturing and operating units
• Us vs. them
• Niche role
• Reactive
• After the fact
• End-of-line control

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Where we are

• EHS professionals are a respected participant in
  the business process
• We are at the table
• Resource for business risk minimization and
  continuity planning (post Y2K, post 9/11/2001)
• Skills transferable, financially savvy
• Proactive and preventative
• Third party EMS registrations

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Where we are going

• Holistic approach to sustainable practices
• Integrated EHS management systems
• No longer separate, but integrated into core
  business functions
• Technical professionals with sophisticated
  business skills (MBAs routine)
• Everyone is involved, cultural approach

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Industrial Evolution

• Sustainability becoming more commonplace within
  the core business of leading businesses
• Hybrid cars becoming mainstream
• Petrochemical companies working on alternative
  fuels
• Carpet companies making recyclable carpets
• Pharmaceutical companies doing green chemistry
• Investment firms recognize value in sustainable
  practices

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What is green chemistry?
the utilization of a set of principles that
reduces or eliminates the use or generation of
hazardous substances in the design, manufacture
and application of chemical products.
Source Paul T. Anastas and John C. Warner,
Green Chemistry Theory and Practice (New York,
NY Oxford University Press Inc., 1998). ISBN 0
19 850698 8
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12 Principles of Green Chemistry

1. It is better to prevent waste than to treat or
   clean up waste after it has formed.
2. Synthetic methods should be designed to maximize
   the incorporation of all materials used in the
   process into the final product.
3. Wherever practicable, synthetic methodologies
   should be designed to use and generate substances
   that possess little or no toxicity to human
   health and the environment.
4. Chemical products should be designed to preserve
   efficacy of function while reducing toxicity.
5. The use of auxiliary substances (e.g. solvents,
   separation agents, etc.) should be made
   unnecessary wherever possible and innocuous when
   used.
6. Energy requirements should be recognized for
   their environmental and economic impacts and
   should be minimized. Synthetic methods should be
   conducted at ambient temperature and pressure.

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12 Principles of Green Chemistry

• A raw material or feedstock should be renewable
  rather than depleting wherever technically and
  economically practicable.
• Unnecessary derivatization (blocking group,
  protection/deprotection, temporary modification
  of physical/chemical processes) should be avoided
  wherever possible.
• Catalytic reagents (as selective as possible) are
  superior to stoichiometric reagents.
• Chemical products should be designed so that at
  the end of their function they do not persist in
  the environment and break down into innocuous
  degradation products.
• Analytical methodologies need to be further
  developed to allow for real-time, in-process
  monitoring and control prior to the formation of
  hazardous substances.
• Substances and the form of a substance used in a
  chemical process should be chosen so as to
  minimize the potential for chemical accidents,
  including releases, explosions and fires.

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Raw Materials
Energy
Natural Resources
Product
NDA
PGM
Intellectual Property
Raw Materials
Waste
Energy
Global RD
Clinical Supply
Natural Resources
Air Emissions
Solid/Hazardous Wastes
Wastewater
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Raw Materials
Energy
Natural Resources
Product
NDA
PGM
Intellectual Property
Raw Materials
Waste
Energy
Global RD
Clinical Supply
Natural Resources
Air Emissions
Control at the source, treat on or
off-site, recycle where possible. Reduce, reuse,
recycle.
Solid/Hazardous Wastes
Wastewater
Waste Minimization Pollution Prevention
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Raw Materials
Green Chemistry
Energy
Natural Resources
Product
NDA
PGM
Intellectual Property
Raw Materials
Waste
Energy
Global RD
Clinical Supply
Natural Resources
Air Emissions
Solid/Hazardous Wastes
Wastewater
Waste Minimization Pollution Prevention
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Sertraline (Zoloft)

• Solvent use reduced from 60,000 to 6,000 gallons
  per ton of sertraline
• Eliminated the use of 440 metric tons of titanium
  dioxide per year
• Eliminating the use 150 metric tons of 35
  hydrochloric acid per year
• Eliminating the use of 100 metric tons of 50
  sodium hydroxide per year
• Increasing the efficiency of raw material, water
  and energy use
• And, doubled the product yield.

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Sertraline Process Solvent Waste/Kg
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EPAs Presidential Green Chemistry Challenge
Award - 2002
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How the amount of waste produced in the
manufacture of sildenafil (L of waste/kg of
product) has decreased over the past 13 years.
1816 L/kg
139 L/kg
31 L/kg
10 L/kg
Medicinal
Optimized
Commercial Route
Commercial Route
Chemistry
Med. Chemistry
(1997)
following solvent
1990
1994
recovery
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Who does green chemistry?

• Chemists
• EHS folks may assist with making the business
  case and providing inspiration/recognition, but
  ultimately its the chemists who do this.
• Example of integration

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Why Green Chemistry?

• Meets the challenge of the triple bottom line
• Economic
• Social
• Environmental

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Green Chemistry TBL

• Economic Aspect
• Lower cost of raw materials
• Lower costs for environmental permitting and
  regulatory requirements
• Lower costs on engineering controls for employee
  safety
• Risk of loss due to accidents, on a macro
  perspective, decreases
• Lower costs for environmental emissions control
  and treatment
• Lower costs associated with inventory control
• Competitive advantage

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Green Chemistry TBL

• Social Aspect
• Fence line issues (odors, unplanned releases)
• Resource sustainability for future generations
• Public outreach/education programs
• Pfizer reputation they expect us to do this

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Green Chemistry TBL

• Environmental Aspect
• More efficient use of non-renewable natural
  resources
• Less impact on the environment due to permitted
  wastewater discharges, air emissions, and
  hazardous waste treatment
• Less risk of incidents and unplanned releases
• Smaller environmental footprint

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