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Thermo Scientific Konelab PRIME 60 and Konelab PRIME 30

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Thermo Scientific Konelab PRIME 60 and Konelab PRIME 30 – PowerPoint PPT presentation

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Title: Thermo Scientific Konelab PRIME 60 and Konelab PRIME 30


1

Thermo Scientific Konelab PRIME 60 and Konelab
PRIME 30
2
Fully automated clinical chemistry systems
  • For medium sized laboratories as a stand-alone
    instrument
  • For high volume testing as a part of automated
    workcell

Konelab PRIME 60 Capacity up to 600 tests/hour
depending on workload
Konelab PRIME 30 Capacity up to 300 tests/hour
depending on workload
3
WORKCELL Automation
  • Single entry point without pre-sorting
  • Minimizes the need of aliquots
  • Workload balancing
  • Centralized control over the system

4
Continuously expanding test range
  • Over 80 carefully validated methods for
  • Enzymes
  • Substrates
  • Electrolytes
  • Specific proteins
  • Drugs of Abuse Tests
  • Therapeutic Drug Monitoring
  • CE marked applications can be complemented with
    user-definable tests

5
Product overview
  • Continuous access to samples, reagents and
    cuvettes
  • On-board capacity of
  • 84 routine samples, 6 STAT samples
  • 39 fixed calibrator control samples
  • 45 reagents in the refrigerated disk
  • 600 cuvette storage positions in PRIME 30,2100
    in PRIME 60
  • ISE option K, Na, Cl-,
  • also Li and Ca2 as optional extra
  • Interface to a sample track system

6
Operational efficiency
  • Automated sample pretreatment feature
  • Automatic sample clot detection
  • Versatile dilution features
  • Pre-dilution possibility
  • Post-dilution with both high and low secondary
    dilution ratios
  • Calibrator set made automatically from one stock
    calibrator for most specific proteins
  • Different sample types can be analysed at the
    same time
  • Important in drug monitoring and therapeutic
    control
  • Reflex testing
  • Saves time and money when finding out the
    specific test to be run

7
Productive, accurate analysis
  • User-safe and contamination free measurement
  • Proven, unique, single use 12-cell cuvette
  • Cost-effective due to low reaction volume
  • Only 100 to 250 ?l
  • Typically 120 - 200 ?l
  • Flexibility and long walk-away time
  • Cuvette storage enables up to 4 hours walk-away
    time
  • Continuous loading access without interrupting
    testing

8
Advanced design to facilitate routine work
  • Integrated workstation with touch screen
  • Enables a working posture with less physical
    strain
  • Ideal for limited space
  • Intuitive graphical user-interface
  • Provides fast guidance
  • Makes the analyser easy to use
  • Available in more than 15 language versions

9
Safe sample handling
  • Error free sample handling
  • Automatic sample identification, direct barcode
    reading and cup/ tube recognition
  • Bidirectional LIS interface for quick data
    transfer
  • Sample tubes
  • 5, 7 and 10 ml tubes
  • 0.5 and 2 ml sample cups
  • Calibrators and controls
  • Cooled positions
  • Possibility to load also into segments

10
Automated sample pretreatment
  • Saves the operator time, e.g. by automating
    hemolyzation in HbA1c measurement
  • Improves quality by minimizing operator variation
  • Dedicated sample segment for whole blood samples
  • For one segment hemolyzation takes about 10 min,
    total turnaround time about 30 min

11
KUSTI - optional module for point-in-space
dispensing
  • Making automatically an aliquot from the primary
    sample
  • Equipped with a 92-positions segment
  • While part of automated workcell requested tests
    processed autonomously
  • Sample is sent further to the next analyzer
  • Minimizing delays on the sample conveyor
  • Manual sample loading using segments possible at
    the same time

12
Automatic clot detection
  • To secure result integrity
  • Based on pressure differential technology
  • Both in sample and KUSTI dispensers
  • The pressure system is calibrated
  • By making a series of air aspirations, takes
    appr. 5 seconds, no extra solutions needed
  • At start up with sample dispenser
  • At every water wash with KUSTI
  • Operator is alarmed about clot
  • All requests are cancelled for that sample
  • Extra wash is performed for needles

13
Clot detection in sample dispenser
  • Pressure signals of succesful aspirations on
    sample dispenser
  • The pressure dives in an aspiration and returns
    through a maximum to the rest level
  • The clot message is sent if in aspiration
    maximum fails to reach the rest level or if the
    end pressure of the curve remains too far below
    the rest level

14
Clot detection in KUSTI dispenser
  • Pressure signals of a succesful aspiration
  • In each sub-aspiration the pressure signal dives
    to a certain depth, but returns to the rest level
    between aspirations
  • The clot message is sent if in aspiration the
    pressure dives deeper than in a successful
    aspiration

15
Convenient reagent handling
  • Continuous monitoring possibility
  • Flagging of expired reagents
  • Determination of vial volume
  • Estimation of reagent sufficiency
  • Automatic bottle change-over increases the
    walk-away time
  • Possibility to run QC with every new bottle
  • Used reagent lots can be archived

16
Simultaneous electrolyte measurement
  • Direct measurement method used in Konelab
  • Generally considered the most accurate ISE method
  • Serum, plasma and urine samples
  • Direct or by manually pre-diluted urine sample
  • Micro volume electrodes for even smaller sample
    volumes
  • Sample volume of only 50 ?l is sufficient for
    Na, K and Cl-
  • Additionally 6 ?l if Li, Ca 2 or pH is required
  • Maintenance-free electrodes
  • Delivered ready-to-use

17
Proactive support
  • Minimal user maintenance tasks
  • About 5 min daily
  • Start up and Stand by procedures
  • Maintenance contracts
  • 6 and 12 months programs

18
Proven technology and experience
  • Konelab analyzers are supported with
  • Customized installation
  • Product training
  • Product Application support
  • After-sales support
  • Maintenance contracts
  • Technical service

19
Confirmed quality
  • Quality system is certified according to the ISO
    90012000 standard extended with the EN ISO
    134852003
  • Konelab Analyzer systems comply with the
    requirements of the In Vitro Diagnostic Medical
    Device Directive (IVDMDD)

20
Key benefits of Konelab analyzers
  • Easy to use
  • Clearly laid out, simple to navigate user
    interface
  • Automation and analyst efficiency
  • Once loaded, the analyzer will run without the
    assistance of the analyst
  • Automatic dilution of an over range sample
  • Automated sample pretreatment feature
  • Reflex test possibility
  • Clot detection
  • Different types of samples can be analysed at the
    same time
  • Important in drug monitoring and therapeutic
    control
  • Productivity
  • Low reagent volumes -gt low cost per test,
    important in expensive tests
  • Quick daily start up
  • Minimal maintenance
  • User-safe and contamination free analysis
  • Disposable cuvettes

21
Key benefits of Konelab analyzers
  • Carefully selected methods and applications
  • Over 150 CE-marked reagents
  • Optimized kits serve laboratories of all sizes
  • Liquid stable and ready for use
  • System-specific multi-calibrators and controls
  • Flexible software
  • Easy method set-up
  • Special applications to be validated by the
    customer or distributor
  • Direct electrolyte measurement
  • The most accurate ISE method
  • Maintenance-free electrodes delivered
    ready-to-use
  • Full application and technical support

22
One reagent line to be used in all Konelab
analyzers
  • Amphetamine
  • Barbiturates
  • Benzodiazepines
  • Cannabinoids
  • Cocaine Metabolite
  • Opiates
  • Cotinine
  • Ethyl Alcohol
  • Methadone
  • Propoxyphene
  • Carbamazepine
  • Phenobarbital
  • Phenytoin
  • Theophylline
  • Valproic Acid
  • Lithium
  • Albumin
  • Antistreptolysin O
  • ? -1-Antitrypsin
  • Apolipoprotein A1 and B
  • Ceruloplasmin
  • Complement C3 and C4
  • C-reactive protein
  • Cystatin C
  • High Sensitive CRP
  • HbA1c
  • Haptoglobin
  • IgA, G and M
  • Lipoprotein (a)
  • Microalbuminuria
  • Myoglobin
  • Orosomucoid
  • Prealbumin
  • Rheumatoid factors
  • Albumin ACP
  • Total and Direct Bilirubin ALP
  • Carbon Dioxide ALT/GPT
  • Calcium AST/GOT
  • Cholesterol Amylase
  • HDL and LDL Cholesterol Cholinesterase
  • Creatinine Dibucaine
  • Glucose CK
  • Iron CK-MB
  • Magnesium Gamma-GT
  • Phosphorus ?-HBDH
  • Total Protein LDH
  • Triglycerides Lipase
  • U/CSF Protein
  • Urea
  • Uric Acid Na, K, Cl
  • Ca, pH

Enzymes
Substrates
DoA (DAT)
Specific Proteins
TDM
Electrolytes
23
Konelab PRIME 60 and PRIME 30
  • Operational efficiency and
  • accurate results!
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