NIH/NIGMS Support of Structural Biology

1
NIH/NIGMS Support of Structural Biology

• NIH individual research grants with
  crystallography projects (FY 98)
• primary 225 grants, 51M total costs
• secondary 400 grants, 96M total costs
• NIGMS is 50 of each
• NIH program projects and NCRR research resources
  approx. 30M for protein crystallography

2
NIGMS Initiative for Synchrotron Beamlines

• Beamline upgrades for benefit of general users
• Reports on increasing demand for user access and
  beamline needs
• Estimate of doubling of capacity for
  crystallographic experiments from staff increases
  and equipment upgrades
• Letter to synchrotron facility directors inviting
  informal proposals
• NIGMS synchrotron advisory group
• FY99 funding of 7M from NIGMS

3
Synchrotron Beamline Upgrades Supported by NIGMS
Stanford Synchrotron Research Laboratory

• upgrades to 4 beamlines
• CCD detectors
• computer
• wet lab
• four beamline scientists/technicians
• one staff for new review/scheduling process
• 1,770K equipment
• 705K annual staff

4
Synchrotron Beamline Upgrades Supported by NIGMS
National Synchrotron Light Source

• reconstruction of bending magnet beamline
• ncluding beamline optics, monochrometer,
  detector, crystallography station
• four beamline scientists/technicians
• 2,372K equipment/construction
• 670K annual staff

5
Synchrotron Beamline Upgrades Supported by NIGMS
Cornell High Energy Synchrotron Source

• upgrades to three beamlines
• beamline optics and cooling equipment,
  monochrometer, automation/ monitors, computer
• two beamline scientists
• 1,238K equipment
• 340K annual staff

6
Synchrotron Beamline Upgrades Supported by NIGMS
Advanced Light Source

• upgrade to the focusing optics for one beamline
  and a detector
• low temperature system and computer for a new
  beamline
• four beamline scientists/ technicians
• 963K equipment
• 259K annual staff

7
Synchrotron Beamline Construction Supported by
NIGMS
Center for Advanced Microstructures and Devices

• construction of a new crystallographic beamline
• two beamline scientists
• cofunded with the NSF, Louisiana State
  University, and a consortium of PIs in the
  southern U.S.
• 1,260K construction/equipment (NIGMS NSF)
• 206K annual staff (NIGMS NSF)

8
Synchrotron Beamline Construction Supported by
NIGMS
Advanced Photon Source

• development of a new crystallographic sector of
  two crystallographic beamlines
• partnership with the NCI
• two years of NIGMS/NCI funding for construction.
• 18M construction/equipment (NIGMS NCI)