Plasma Glucose Homeostasis Widmaier et al., p. 567-580

1
Plasma Glucose HomeostasisWidmaier et al., p.
567-580

• Glucose metabolism
• Hormonal Control
• Disruptions of glucose homeostasis
• Case Study

2
Homeostasis of Plasma Glucose Concentration

• Normal physiological range 65-100 mg/dl
• What is the set point?
• Why is too much plasma glucose harmful?
• Plasma glucose concentration glucose entering
  the plasma glucose leaving the plasma
• What are the mechanisms that regulate plasma
  glucose concentration?
• What are the components of the negative feedback
  loop
• Glucose receptors?
• Afferent pathway?
• Integrator?
• Efferent pathway(s)?
• Effector organ(s)?

Phasesabsorptive, post-absorptive, and
fasting
3
Fig. 16.01
Lipoprotein Lipase
Absorptive Phase
Hepatic Portal System
Once inside, glucose is converted to something
else, thereby maintaining a concentration
gradientfor facilitated diffusion ofglucose
into cells.