???????????????,????????????????(Silent killer),??????????????????????????

1
?????????????????
2
???

• ???????????????,????????????????(Silent
  killer),??????????????????????????
• ?????????????,????????????????,?????????,????????(
  Systolic pressure)??????,????????,???????(Diastol
  ic pressure)?

3
???????

• (1) ??????(Borderline hypertension),??140/90
  mmHg?159/95 mmHg???
• (2) ???????????95?????(mmHg),?????160?????(mmHg)?

4
???

• (1) ??????????(Borderline isolated systolic
  hypertension)142-159 mmHg
• (2) ???????(Isolated systolic hypertension)gt160
  mmHg

5
???

• (1) ?????lt85 mmHg
• (2) ????85-89 mmHg
• (3) ??????90-104 mmHg
• (4) ??????105-114 mmHg
• (5) ??????gt115 mmHg

6
??????????????

• lt6?lt110 / 75 mmHg
• 6-10?lt120 / 80 mmHg
• 10-14?lt125 / 85 mmHg
• 14-18?lt135 / 90 mmHg
• 18-50?lt140 / 95 mmHg
• gt50?lt160 / 100 mmHg

7
????????????

• ?????130/85 mmHg
• ??????130-139/85-89 mmHg
• ?????140-159/90-99 mmHg
• ?????160-179/100-109 mmHg
• ?????180-209/110-119 mmHg
• ??????gt210/120 mmHg

8
??????

• ?????????????????????????????????????(?????????)?
  ????????,??????????

9
??????

• ??55?????????,???????,?????????????????,??????????
  ???(???,?????????)???????,????????????????????????
  ????????????????(??????),????????

10
????????

• ?????????????????????????????????????????????

11
????????1

• ??
• ?????????????????(Diurectics),???????????(hyponatr
  emia)?????(hypochloremia)??????(hyperuricemia)????
  ?(hyperglycemia)???,?????????????????????????????,
  ?????????,???????????????????

12
????????2

• ????????????????????????,???????????(Sympatholytic
  agents)?
• ????????(Vasodilator)??????????,??????????????????
  ?????????????

13
????????3

• ??????????????????(ganglionic blocking
  agents)???????????????????????????????????????????
  ???????????????,?????????

14
????1

• ???????,??????500-1000??
• ?????,????,????1200-1500?,????????
• ??????????50-60?
• ?????????

15
????2

• ??????????????,????????????
• ????,?????????
• ???????????????
• ???????????????????,????????

16
???????

• ?????????????
• 1 mEq?23 mg,100 mEq2.3 g?
• 1 g?0.4 g?,1000 mg?2.5 g?

17
??????1

• ??????????
• ??????????
• ???????,???????(IBW)
• ?????????
• ????
• ????

18
??????2

• ????????
• ???
• ???????????????
• ??????????????
• ??????????
• ?????????
• ?????
• ?????????
• ?????
• ??????,????,????????,????,????????,??????????

19
?????

• ?????????????????????,????????????LDL-?????,??????
  ????
• ?????,???????????(???????)????????,??????????
• ???????????????,?ß-?????,??a-???,?????????????????
  ?,??????????????

20
???????/??????

• ???????/??????(Cholesterol/ saturated-fat index
  CSI)
• CSI?????????????????????,????????????????
• ?????CSI??47???29???37???9-18???4-5???(??) 6?
• CSI(1.01????????)(0.05???????)

21
???????(Atherosclerosis)

• ???????????????????,???????????????????????

22
????

• ??????????????????????(sulfated
  polysaccharide)???????(collagen)???(debris)???????
  ???
• ??????????????????????,??????????,????,????,??????
  ??,????????

23
?????

• ????????????(cerebral vascular thrombosis),?????(S
  trokeCerebrovascular accidentCVA)
  ,???????????????????????????

24
??????

• ?????????????????(Coronary heart
  disease),?????????????????

25
?????

• ???????????????(Nephrosclerosis),?????????????????
  ??????????????????,?????(Claudication),??????????
  ??????????????

26
????

• ?????????????????,????????,???????,?????????
• ???????(150 mg/dl??),??????(hyperlipidemia),??????
  ???
• ?????

27
?????

• ???????,?????,??????,?????????LDL????170
  mg/dl??,???????(VLDL)??300 mg/dl,?????????,?HDL??
  ???50 mg/dl?

28
?????????

• ??????????????????(?????7.5 mg/dl)??????????
• ?????(????????????)???,???????

29
??

• ??????(Nicotine) ????????,???????????????,????????
  ???,?????????,???????????,?????????????

30
?????

• ???????,???LDL???HDL,?????????,???????????

31
????

• ???????????,??????????,??????????????????,????????
  ????
• ?P/S ?????1?,???????????

32
??

• ?????-3????????????LDL?VLDL???,?????????????30??,
  ????????????

33
??????

• ??????,?????????????(????150 mg/dl),??????,???????
  ,????????,??????????50-60,??????????

34
????

• ????????,??????????,????????????,???????????
• ?????????,?????????,???????????,?????,?????????
• ??????????????????????,??????????
• ?????????????????,????????????????

35
??

• ???????????
• ??????,???????
• ???????
• ??????
• ?????,?????????????????????????,??????
• ?????????????,??????
• ???????,???????,??????,???????????,?????,???????

36
?????

• ????????????????,?????????,????,???????????????,??
  ???????????????,??????????????,????????????,??????
  ??????,????????????????
• ????????????????????

37
??????

• ???????,?????????,????????????????????,???????????
  ??
• ????,????????????,??????????????????????????,?????
  ?,????????????

38
????

• ???????????,????1200-1500???????,?????????????????
  ??????????????(???????30)?????(???????25)??????(
  ???????10)?

39
P/S(??????/?????)

• ?P/S??????????,?????1200??,PS1.11????1800???,P
  S1.31????2300??,PS1.51?

40
????????????10-11??

• ?????????????,??????????,???????????????????
• ??????,?????????????10,?????????????10-11???

41
?????????300 mg

• ?????????????????300 mg,?????????????,?????????,??
  ???,????????????,???????????????????

42
???????

• ?????????????(??????40)
• ???????????????????????
• ?????????,??????????

43
????????????

• ?????,??????A,??????????????????
• ?????????????????????,??????????????
• ???????????????

44
???????

• ?????????????,???????30,???????10,???????10,??
  ?????300???????????
• 2. ???????????25-30,????????200????????????
• 3. ?????????????20-25,????????100??,???????55-60
  ,??????????3?,????????????????????

45
????(Pritikin diet)

• ?????????????????????,??????????????(???????10,??
  ????25 mg),?????????????160 mg/dl??????????100
  mg,??????75-80,????????????

46
??????(Hyperlipoproteinemia)

• ?????????????????????????????,????????????,???????
  ?
• ?????????(Hyperchylomicronemia)??????????(Hyperpr
  e-ß-lipoproteinemia, VLDL),VLDL????300 mg/dl??

47
?????????

• ?????????(Hyper-ß-lipoproteinemia,
  LDL),LDL????170 mg/dl????????????(Hypo-high
  density lipoproteinemia,HDL),?HDL???(?HDL????40
  mg/dl??)?

48
???

• ??????????(???????????????),?85??????6????5????
  2????2?????,????????????

49
???????

• ???????(VLDL),?????50??????8??????12????10????
  18???,??????????????????????

50
??????

• ??????(IDL),?VLDL?LDL???????????(LDL),?ß-???,????
  ?????37,?????????????

51
??????

• ??????(HDL),?50???,?a-???,???????????????????????
  ,??????????????,????????????????

52
???

• ???????????140-220 mg/dl,??????????? ??A(Acetyl
  CoA),??????? ??A??,?????????????????,??????????,?
  ????????D??????????,????????????

53
?????????

• ??????????,????????????,?????????????,????????,???
  ???,?????????????????,????VLDL???????

54
???????

• ??????????,?????????,????????80?????,??????
• ???????,???????(Lipoprotein lipase)????????,??????
  ??????HDL

55
??????HDL

• HDL???????? ???(Lecithin-cholesterol
  acyltransferase,LCAF)???????????,???LDL???????????
  ????????????????,?????HDL????,???LDL???,??????????
  ??

56
???????

• ??????????
• 1. Type I????????,??????????(Lipoprotein
  lipase)????????????(gt1000 mg/dl)??????????????,???
  ???,??????????????????????

57
Type II

• ?ß-??????????Type IIa?Type IIb?
• Type II a???????,LDL??,??????VLDL??????????????,?
  ???????????????????????
• Type II b??????????????,????LDL?VLDL?????????????
  ,???????????????????

58
Type III

• ???????(150-1000 mg/dl)????(350-800
  mg/dl)???????ß-?????,?????????????????????????????
  ?

59
Type IV

• Type IV?????????????,?????????VLDL?,?????????????
  ??,????????????

60
Type V

• Type V????????????????VLDL??,??????500-5000
  mg/dl???????,????????????????????????????????

61
????

• ?????????????,???????????190mg/dl?,???41.3
  mg/dl,???160mg/dl?,????4.8mg/dl?

62
?????????

• ???????????????????????,??????????????
• ????????????????,??????????????????????????,??????
  ?????????

63
??????????,??????????????

• ????????????,?????????????????????????,??????????
  ????

64
???????????

• ???????,????????????????????,??????????,?????????
  ????????
• ???????????????????,?????????

65
????????200??

• ?????????????????????????(??300????)?????????(10?
  ?)?
• ??????????,?????????????????????200??150??????????
  ?7???

66
??????????

• ??????????????????????????????,????????????????
• ??????
• ????????????,???????,?????????????????
• ??????(1)????????2???
• ????????????
• ??????,???????
• ???????,????????????