???????????????????? HIV ???????

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???????????????????? HIV ???????

• ?? ????? ????????????

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Graph showing HIV copies and CD4 counts in a
human over the course of a treatment-naive HIV
infection
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• ????? ?????????????? ?
• ??????? 1 ????????????? (acute HIV
  infection)2-3 ?????????? ?????? 40-90
  ??????????? ??????? ???????? ??????
• ??????????? ???????? ???????????????????????????
  ??????????? ????????? ??????????????? ??????????
  ????????? ??? ??????????????? ??????????? 10-14
  ???????????????
• ???????????? antiHIV ??????????????????????6-8?
  ??????
• ????????????????????????? 3 ?????
• ????? 5 ????????????????? 6 ?????

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• 2. ??????? (latency stage)
• ?????????? 2 ??????? ??? 20 ??
• ????????????????????? ??????????????????????????

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• 3. AIDS
• ???????????????? ????????????CD4

?????????????? CD4 ??????(TB), ?????? (Herpeszoster), ???? (Herpes simplex)
CD4 200-180 (early AIDS) PCP, candiadiasis, Oral hairy leucophakia
CD4 120-80 (late AIDS) Cryptococcosis , Histoplasmosis Penicillinosis, Toxoplasmosis Cryptosporidium , Isosporidium (????stool modified AFB)
CD4 lt50 (advance ) MAC ,CMV ,PML, ,Norcardia (LN???)
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Herpes simplex virus type 1


Herpes simplex virus type 2
?????? ??? ????
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PCP
Pneumocystis jiroveci
?????????????? ?????????????????
????????????????????????????????????????
50 ????????? ??????????????? ?????????

• ????????? sputum induction
• (???? Geimsa )

• ??????????????????????(bronchoscopy.)

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oral hairy leukoplakia
EBV-induced epithelial hyperplasia
mostly involves the lateral border of the
tongue, but can involve other oral sites
including the buccal mucosae
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Cryptococcosis

• Pulmonary cryptococcosis
• CNS cryptococcosis
• Cryptococcosis in other sites
• After lung and CNS infection, the next most
  commonly
• involved organs in disseminated cryptococcosis
• include the skin, prostate, and medullary cavity
  of the bones.

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Histoplasmosis
pulmonary histoplasmosis
Progressive disseminated histoplasmosis
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Penicillosis
??? ????????? ??????????????? ????????? ???
Toxoplasmosis
??????????? ?????????????????????????????
????????????????????????????? ?????
??????????????????????????????? ???????? ???
????????? ????????
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Cryptosporidium

• ?????????? modified acid fast ??????????????
• ??????? sporozoite ????? 2-4 ???????????? oocyst

• ?????????????????? ???????? ??????? ???????
  ??????????
• ????????????????????????????????? 7-10 ?????
  Cyclospora

• watery diarrhea, steatorrhea,
• ???????????????? ????????????????????????????? ?
• ?????????????????????
• malabsorption ????????????????????????
  ???????????  ?????????????
• ??????????????????????????????????

Isospora
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Cytomegalovirus (CMV)

• ???????????? CD4 ??????? 50

Retinitis Esophagitis ,Colitis (??????????????
???????? ??????? ????????? ) pneumonia
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MAC

• ???????????? CD4 ??????? 50

• ??????????????????????? ?????????????????????????
  ???
• ????? ???????????????? ????????? ?????????
  ????????????????
• ???????? ????????????? ??????? ????????
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