Double Edged Sword of Antibody

1
??????

• Double Edged Sword of Antibody

2
????

• ?????
• ?????
• ?????
• ??????
• ????????
• ???????

3

• ??????????,????????????????????????

??????????????B?????????? ???????????????????????,
??????????
4
???(constant region,C?)
???(variable region,V?)
???(hypervariable regions)
???(frame region)
5
?????
IgG2H2L LVLCL HVH3CH
6
???(hinge region) ???????????????????????????
?
??? ????
????? ???????N Fab?/Fc?
???? ???????C F(ab)2?/PFc?
7
??????? (Properties of Antibody Classes)
??????????????
????(membrane bound)??BCR???B??????????????????
8
??????

• ? ????????????????????????Ig???(gamma)?-IgG
  ,???????,???IgG1?IgG2?IgG3 ?IgG4a(alpha)??IgA,? ?
  ????(???IgA,SIgA)????,???IgA1? IgA2
• µ(mu)??IgM,?????????,??IgM1?IgM2
• d (delta)??IgD,??????
• e(epsilon)??IgE,??????
• ??????????????????K?(Kappa)? ??(Lambda)??-Ig????
  ??L????????Ig????????L?????????,????????Ig
  ??21?

9
??????????
10
????????
11
1.???????(Recognition of antigen)

• ?????????,???????????????????????????????????
  ???????????

12
2.????(Activation of complement)

• IgM?IgG???????????????????IgA?IgG4?IgE??????????

13
3.??Fc?????(Opsonization)

• ????????Fc???IgM?IgG?Fc?????????Fc????????????,?NK
  ?????Fc????ADCC,??NK????????

14
(No Transcript)
15
(No Transcript)
16
4.???????

• IgG???????????,?????????????? SIgA????????????,??
  ????????????

17
5.Ig??????????????

• ?????????????,?????????

18
(No Transcript)
19
???????

• ??????
• ??????

20
??????

• 1 ??????????(???lgE)???????????????,?????????????
  ?????????
• ???? lgE

21
2 ???lgE???????

• ??????????,?????????????????

22
3??

• (1)??
• ???????lgEFC?????????lgE?????
• (2)??
• ???????????????????
• ??????????????
• ??????????,???????????
• (3)???????
• ???????????????,???????????????????????
  ?,IgE??????????????,????????????????????????? ??

23
????
24
???
????? ??? ?? ??? ?????? ??????
25
(No Transcript)
26
4 ????????

• (1)??????????????????????
• (2)??????????????,????????
• (3)???????,????????????????????

27
??????????(IgG?IgM)?????????????,????????????????
??,???????????
???????????? ?????????????????,???????????????,??
?????????
?????? ????TD???????????????????????????????????
??????,??????,???????,?????????????????????????,??
?????????
28
?????
29
?????
30
??? ????????????(???)?12???? ????????????????????
???,???????????????????????
31
??????

• ?????????????????????,????????????????????????????
  ???????,????????????,??????????
• ???????????,????????????????

32
???????
33
?????????

• ????????,???B?????????T????????????
• ???T????????T??????????????,
• ????????????????Fc???????
• ??????80,???30?????,??????????

34
????

• ??????? ?
• ???
• ???
• ? ?
• ???