????CAD

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????CADCG???????
2003?12?
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State Key Lab of CADCG, Zhejiang University
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• 21??????????,??????????????????????????????

State Key Lab of CADCG, Zhejiang University
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• ???????????????????,????????????????????????10????
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• - ??????????SARS???3???????
• ?,?????????????????????
• ?SARS??????????
• -

State Key Lab of CADCG, Zhejiang University
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• ?????DNA(????????)???
• - ?????? ---ATCGGCC---
• ---TAGCCGG---

State Key Lab of CADCG, Zhejiang University
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• ????(The Central Dogma)

State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• - ?????
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• - ????????????,
• ??-helix, ?-sheet?
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• - ????
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• - ????????

State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• ???????????????

• Examples
• - ???????????
• - ??????

State Key Lab of CADCG, Zhejiang University
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??????????? - ?????????(P53)
State Key Lab of CADCG, Zhejiang University
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• ??????
• - AcrA
• AcrB
• Tol C
• - ???
• ???
• ??

State Key Lab of CADCG, Zhejiang University
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??????????? ???????(living molecules)?????, ???21
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State Key Lab of CADCG, Zhejiang University
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• ????
• ????
• - HTS
• High
• Throughput
• Screening
• - ???????

State Key Lab of CADCG, Zhejiang University
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• ????

• ????

State Key Lab of CADCG, Zhejiang University
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• CPK??

State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• - ????????????????,?
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• ???,??????????

State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• ??Docking???????
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• ??????????

State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• - ???????????????????
• - ????????????????????????
• ???
• - ??????????????

State Key Lab of CADCG, Zhejiang University
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• ????????????????
• - ????????????????
• - ???????????????????
• - ????????CAD?????
• - ??????????????
• - ??????(Biology pathway)?????????
• - ???????????

State Key Lab of CADCG, Zhejiang University
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• - ????????????????
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• - ?????????????????
• - ??????????????????????
• ????

State Key Lab of CADCG, Zhejiang University
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• ???????????(???????),?????????????

State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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• 20???????????????????????????
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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State Key Lab of CADCG, Zhejiang University
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NSFC??? ?? 2003?12?2628?
State Key Lab of CADCG, Zhejiang University