Some TNFa induced signaling pathways

1
Some TNFa induced signaling pathways
TNF-mediated clustering
TNFa
TNFa
TNFR2
TNFR1
TNF-Receptor 1
TNF-Receptor 2
(p75)
(p55)
TRAF2
DD
TRADD
FADD
TRAF-domain
TRAF2
TRAF1
IAP1/2
Death domain
Pro-Caspase-8
NIK
NIK
IKKg
RIP
Caspase-8
P
IKAP
GCK
MAPKKKs
IKK1
IKK2
P
IkB Phosphorylation on Tyr42 (via c-Src)
Apoptosis
MEKK1
IkB
degradation in proteasomes
MKK6
IkB phosphorylation (S32,36)
ubiquitinylation
MKK7
JNK pathway
p65 phosphorylation on S276
p38 pathway
LPS
PKA pathway
NFkB
p50
p65
p38s
SAPKs (JNKs)
p65 phosphorylation on Ser529
p38 pathway
Jun, Elk, Fos, ATF2
CBP..
co-activators
AP-1
mRNA for inflammatory genes, IkB, IAPs, A20,
TRAFs,...
P
transcription
DNA
nucleus
Johannes Schmid 12/98