????? Dendritic cells

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?????Dendritic cells

• ------APC?????

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?????----DC

• ?????(Dendritic cells, DC)????????????????(Antigen
  presenting cells, APC),?????????????????,???DC???
  ??????,??DC????????T??,?????????????????????

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(No Transcript)
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?????
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??????????

• ?????????????
• ???????????????
• ????????????
• ??????????????
• ????

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Where is he come from(??)?
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???????
1??????? 2???????
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??????

• ????DC?????????
• ? ??DC??

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??????

• ???????(DC1)Myeloid DC
• ????????(DC2)Lymphoid DC
• Also known as MDC and LDC.
• How do they function as DCs?

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MDC function as this
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LDC function as this
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??
??
??DC??
?????
???DC
??DC???????
??????????????? ??????????????
??
????????????? ?????,????????
??????????
DC??????????????
??????????????? ,???????????
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??DC???????????????????????????????????????
????DC??????????????????????????????DC,???????????
???,MHC-????????,??????DC???????????????????????,?
???????????????????DC,??DC??????????T???????T?????
??T???????????
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? ?????????????
1????????DC???? 2?DC?????????? 3?DC?????
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??????DC???? ??
?????????DC???? ???????????DC???????? ?????DC???
? ???????DC???????????
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DC??????????
1.DC???????????????????? 2.DC???MHC
II???(gt106/??),DC??????(Vacuoles)??,?M//C?C//VS,??
MHC II??????,????MHC II???????MHC-????????DC?????T
?????
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DC??????????
3.DC???????????????,?ICAMs?LFA-3?ß-????B7s?CD40?IL
-12?,????DC?T??????????(????????DC???????????)?
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DC??????????
4.DC??????CD83?P55?S100b???????Ig?????,??EBV?B???,
??????T???DC????S100b??????,????????DC????????????
? 5.DC??CD40??????TRANCE/RACK??,?T???TNF??????
???DC,????CD80?CD86???,????IL-12,??IL-8?MIP-1a?ß??
????
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DC?????
???DC???????,??????????DC?????????? ??????CD34???
????????????DC???? ?GM-CSF??????????????TNF-a,CD4
0L???????????DC???IL-4????????????????????????DC?
??
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???,??DC???????????,??????????????,??GM-CSF?TNF
-a?IL-4?,SCF?FL?IL-13???????DC???????,??,???DC????
?????DC?????????
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? ?????(DC)?????

• B?T?????????,??????DC????
• 1.DC?B??
• 2.DC?T??

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1.DC?B??
?DC?B????????????????????
?????APC,?DC???MHC?????????????????IL-12DC??Fc???
???(multilectin)??????,B?????????????????
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???B????????LC?DC??,?DC???IL-12???????DC?????
B??????????????,IL-10?TGF-ß??IgA1???,IgA2?????????
B?DC???????,???DC?????????
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????DC??????B???????????,??????CD11c DC
,?????????,??????B?????? ?DC?B??????????????,?D
C????????BCR????????,B????iccosomal???ThDC?CR2L?B
???CR??,????????????????????
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2.DC?T??
T?????????????????????T??????????,?????????T????
????????????????DC??????????DC??????????,????????M
HC????T??,?????????????????????T???????
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DC???????????????
??????ß??????,?draining?????BM-APC???T??,???????,
T???????????????,DC?????????????11,??,DC????????
????????T??????????????
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??T?????????,DC???CTL????????,CD1aDC???IL-12,??
???T???NK????,??Th0?Th1????,????Th1?Th2???????DC??
??????
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??,??????DC???????????? ?????,???DC?????????
???DC????????????DC,??LC,????????????????????????
?
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??????T?????????
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? ????????????

• ??DC????????,?????T?????????????,????,?????,??,??
  ????????????????DC???????

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DC????????????????????,?????????DC????,????,????DC
??????????????????????,????????????DC,???????DC?DC
????????
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1. ???DC ex vivo???????????????
??????????????????DC????????????????????????????,?
????DC?????????,???????????????????????DC?????????
???
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2. ?????????????????????DC?
?????????DC???????????????,???????APC?MHC?????????
???????,?????????????
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3. DC???????????????,?????DC?????????????????
CTL? ????????????DC,??????DC???????????,?????
???????MHC?????????CTL????????????????????.


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????(DC)????
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? ??
??,??????????,??????????????(???DC)????????????
?DC????????????????????DC,??DC???????????,DC??????
??DC?HIV????????,???????????????????????DC????????
,????????????DC???????????????
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• ???DC??????????,????,??????????,??????DC??????????
  ???DC??,??????????????,????????????????T??????????
  ???????????????????,???????????

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??,DC????????????,????????,?????????????????????
????????????????,???????????????,?????????????????
????,?????????????????????
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??DC???
????!
???????
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???DC??
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??DC?? (FDC)