Title: Comparison of Orbscan and Ultrasound Pachymetry Measurements
 1Comparison of Orbscan and Ultrasound Pachymetry 
Measurements 
Faik Orucov, MD, Abraham Solomon, MD,Ziv Caspi, 
David Landau, MD, Eyal Strassman, MD, and Joseph 
Frucht-Pery, MD
Department of Ophthalmology, Hadassah University 
Hospital School of Medicine  Hebrew University, 
Jerusalem, Israel 
RESULTS
BACKGROUND
An excimer laser surgery has become the most 
common procedures performed for correction of 
ametropias. The preoperative evaluation of 
refractive laser surgeries include refraction, 
topography and orbscan examination, Schirmers 
test, pupil size, pachimetry, intraocular 
pressure, slit lump and dilated fundoscopic 
examination. Accurate assesment of corneal 
thicness is an important part of the refractive 
surgery workup.
6466 eyes were included in the study. Orbscan II 
measurements were significantly higher than US 
pachymetry measurements when applying the 
manufacturer-recommended acoustic correction 
factor of 0.96 (553.8  41.2 micron and 531.7 
31.6 micron, respectively) (P lt 0.0001). Corneal 
thickness measured by US pachymetry was 
approximately 22.1 19.7 microm (4) higher than 
the thickness measured by Orbscan II with 
correction.
A significant correlation was observed between 
ultrasound pachymetry and Orbscan slitscan 
pachymetry (Pearson correlation coefficient, r  
0.887 P lt 0.001). Analysis of regression showed 
a significant linear regression between the 
values obtained with the devices (P lt 0.0001, F 
test).
PURPOSE
To compare central corneal thickness measurements 
(CCT) using Orbscan II (Bausch and Lomb, 
Rochester, NY) and Sonogage ultrasonic (US) 
pachymetry in normal eyes of large population. 
Ultrasonic pachymetry 
METHODS
Orbscan pacymetry 
 Preoperative central corneal thickness 
measurements obtained by Sonogage ultrasonic 
pachymetry and Orbscan II in patients who 
underwent LASIK procedures between January 2002 
and January 2006 were analyzed. Thinnest point 
included for Orbscan II and for US pachymetry 
after at least 3 repeated measurements. 
Ultrasonic pachymetry and Orbscan pacymetry ( 
custom acoustic factor  0.96 )
The cylinder was higher in negative differences 
than the positive differences (Mean -1.261.4 
diopter and -0.870.9 diopter Plt0.001) while 
simKs were same between groups ( P0.491 and 
P0.585 ). 
CONCLUSION
- Orbscan scanning-slit system obtained 
significantly different values for corneal 
thickness. The differences between two devices 
are more in thick and thin corneas. The degree of 
variability within each group indicated that 
these two techniques are not clinically 
comparable. These differences are important for 
planning and measuring the effects of corneal 
refractive procedures.  
Student t test was used to identify significant 
differences between methods, and the correlation 
between methods was determined using the Pearson 
bivariate correlation. 
The differences between orbscan and US pachymetry 
are divided to three as, high positive difference 
when orbscan measured thicker than 22 micron and 
high negative difference when orbscan measured 
thinner than 22 micron and small difference when 
measurements were  22 micron. High positive 
differences appeared in thicker corneas (Mean 
575.432.4 micron and 538.229.4 Plt 0.001, 
orbscan vs US pachymetry ) while high negative 
differences appeared in thin corneas ( Mean 
477,9 44.1 micron and 514.1 45.4 micron Plt 
0.001, orbscan vs US pachymetry ).