14-3 Human Molecular Genetics

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14-3 Human Molecular Genetics
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Testing for Alleles

• Genetic tests are now available for hundreds of
  disorders
• Tay-Sachs
• Cystic Fibrosis
• Sickle Cell
• Helps parents see what disorders they risk
  passing to their children

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DNA Fingerprinting

• Analysis of sections of DNA that have little or
  no known function, but vary widely from one
  individual to another, in order to identify
  individuals.
• What does this mean? How is it done?

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What is DNA Fingerprinting used for?
Forensic Science (Crime Investigations Body
Identification)
Paternity Testing
Missing Persons
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Review
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The Human Genome Project

• It took 10 years to sequence all 46 chromosomes
  (1990 2000)
• Human genome roughly 3,000,000,000 base pairs
  (3 billion bp)
• How is it done?

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Human genome roughly 3 billion base pairs
Longest Genome Sequence to Date
Loblolly pine 23 billion base pairs

• E. coli genome 5 million base pairs.

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• 21,000 genes are on the 46 chromosomes in the
  Human Genome

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Gene Therapy

• The process of changing the gene that causes a
  genetic disorder by using a recombinant virus
  (vector) to insert an unaffected gene into the
  DNA.
• An absent or faulty gene is replaced by a normal,
  working gene.

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