1224 STEMI pts, no reperfusion, < 24 hours from onset

1
Treatment with Enoxaparin and Tirofiban in acute
MI (TETAMI) M.Cohen et al, Beth Israel Hospital,
NJ

• 1224 STEMI pts, no reperfusion, lt 24 hours from
  onset
• 4 treatment groups
• Enox 30 mg iv plus 1 mg/Kg sc bd alone
• Enox 30 mg iv plus 1 mg/Kg sc bd with Aggrastat
  100 ug/Kg IV
• UFH 70 U/Kg plus 15 U/Kg per hour infusion
• UFH 70 U/Kg plus 15 U/Kg inf. with Aggrastat 100
  ug/Kg IV
• Subgroup analysis showed protective Tirofiban
  trend in
• Pts treated within 12 hours
• LV dysfunction
• Study underpowerd for mortality

2
Outcomes in TETAMI
End points (all 30 days) Enoxaparin Enoxaparin tirofiban UFH UFH tirofiban
Randomized patients n229 n305 n306 n314
Death/ recurrent MI/ recurrent angina 15.4 16.1 17.3 17.2
Death/ recurrent MI 8.7 8.5 9.2 8.0
Treated patients n297 n303 n306 n310
Major hemorrhage 1.0 2.0 1.0 1.6
Hemorrh. stroke 0.0 0.3 0.0 0.3
Cohen M. American Heart Association Scientific
Sessions 2002.