Lehninger Principles of Biochemistry 5/e

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Lipids
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Butyric 4 COOH-CH2-CH2-CH3
Myristi 14 COOH(CH2)12-CH3
Palmitic 16 OOH-(CH2)14-CH3
Stearic 18 COOH-(CH2)16-CH3
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Palmitoleic Palmitoleic w7 1619 1619 1619 -0.5
Oleic Oleic w9 1819 1819 1819 13.4
Linoleic Linoleic w6 1829,12 1829,12 1829,12 -5
y-Linolenic y-Linolenic w6 1836,9,12 1836,9,12 1836,9,12 -11
Arachidonic Arachidonic w6 2045,8,11,14 2045,8,11,14 2045,8,11,14 -49.5

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1-???????? ????
???? ??????
CH3(CH2)7CHCH(CH2)7COOH H2 -
CH3(CH2)7CH2CH2(CH2)7COOH????
????????2-??????? ????CH3(CH2)7CHCH(CH2)7COOH
Br2 -CH3(CH2)7CHBr-CHBr(CH2)7COOH3-?????
????R-COOH HOR R-COORH2O

• ???? ???? ??? ????

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4-?????????? CH3(CH2)7CHCH(CH2)7COOH1/2O2
-CH3(CH2)7CHOCH(CH2)7COOH????????CH3(CH2)7C
HCH(CH2)7COOHO2 --CH3(CH2)7CHO-CHO(C
H2)7COOH???????CH3(CH2)7CHCH(CH2)7COOH2O2
-CH3(CH2)7COOHCOOH(CH2)7COOH???????
?????????
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??? ???????-??? ???? ???????

• 1-??????? 1 ???? ??? ??? ???? ???????
• CH2-O-COR
• CHOH
• CH2OH
• 2-??????? 2 ???? ??? ?? ???? ???????
• CH2-O-COR
• CH-O-COR
• CH2OH

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3- ??????? 3 ???? ??? ??? ???? ???????
CH2-O-CORCH-O-CORCH2-O-COR
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?????

• 1CH2-O-COR
  CH-O-CO-R2
• CH2-O-CO-R3

• CH2-O-COR
• CH-O-COR
• CH2-O-COR

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???? ???????

• 1-?????? ???
• CH2-O-COR CH2OH
• CH-O-COR1 3KOH CHOH
• CH2O-COR2 CH2OH
  
• ????? ???? ??? KOH ???? ???? ?????? ???? ?? ???
  ???? ?? ????? ?????? ?? ?????.

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2-????? ?? ????????????? ??? ??? ?? ??????
???????? ?????? ????? ?? 100 ??? ???? ??? ???
????? ??? ?????? ?????. 3-??????? ??? ????
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?????????????-?????????????????

• CH2OH CH2-O-COR
  CH2-O-COR
• CHOH 1CH-O-COR
  CH-O-COR1
• CH2-O-PO3H2 CH2-O-PO3H2
  CH2-O-PO3H-X
• ??????? 3-????? ???? ?????????
  ?????? ????? ???????????

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-????????? ????? (??????)

CH2-O-COR ????
?????-????? ????? ?? ?????? ???? ????-????? ????
????CH-O-COR1
CH2-O-PO2H-O-CH2CH2N(CH3)3 - ?????????????
????(???? ??????) - ??????
???? ????????? ????? - ??? ?????????
??????? ????? ??????? ??? -
??????? ????? ??????? ???? ??????
- ?? ???????? ?????? ?????????- ??????
?????? ?????
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-????????? ?????? ????(??????)CH2-O-COR
???? ???????
????CH-O-COR1CH2-O-PO2H-O-CH2CH2NH3
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3-????????? ????CH2-O-COR
??????? ????CH-O-COR1CH2-O-PO2H-O-
CH2-CHNH3-COOH4-????????? ?????????CH2-O-COR
1-?? ???? ??????? ???
????CH-O-COR1
2-????????? ??? ?????CH2-O-PO2O- C6H5O6
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5-?? ????????? ?????????(???????????)CH2-O-COR
CH-O-COR1CH-O-PO3-CH
2-CHOH-O-CH2-CH-O-COR2CH2-O-COR36-????????????
CH2-O-CHCH-R1 10 ???????
???CH-O-COR2CH2-O-PO3-CH2-CH2-NH3
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?????? ???????CH3-(CH2)12-CHCH-CHOHCH-NH2

?????????CH2OH
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 1-???????????????????? ???? ??? ??????
??????? ???? ? ??????? ???
-???????????? ???? ??????? ??????
????????????????2-??????????????????? ????
?????? ????????????? ????????????
?????????????????? ???????????????? ??????
???? ????????????????
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3-??????????????????? ????? ?? ????????????
6 ???? ??????? ??? ???????????????????-N-
????? ???????????? ??? ??? ????? ?????
??????-???? ??? ????
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???????2/3 ???? 1/3
???????? 1-??????????? 2-????????
?????7-?????????????7-?????????????-------
VIT D3?????????------- VITD2
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?????? ??????? ?? ???? ??????????
204(5.8.11.14) ???? ???????????
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??????????? ??1-?????????? ?? ????? ??????
0.94??? 75-100 80-90 TG 1-2
PRO2-??????????? ??? ?? ????? ???????
VLDL)) ????? ???? ?? 0.94-1.006 ???30-50-
TG55-65 PRO103-LDL ????? ????
1.006-1.063 ??? ?20-22 PRO 25 ? CHOL
50-604-HDL????? ???? 1.063-1.21 ???7.5-10
PRO45-55 CHOL35
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