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Boron Neutron Capture Therapy BNCT : * K ... – PowerPoint PPT presentation

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Title: ?fa?

1
?fa?µ??? t?? ?et??????? s??????? st? ?e?ape?a
t?? ?a??????

Boron Neutron Capture Therapy
BNCT

??p???s? Sa??? ?????
2

K??e ????? ??? ?a? pe??ss?te??? ?????p??
pe?a????? ap? ?a?????, pa?? ap? AIDS, f?µat??s?
?a? e????s?a µa??, ?e????? p?? ?fe??eta? s?µf??a
µe t??? ep?st?µ??e? st?? d?t???p???µ??? t??p?
????, t?? t??p? d?at??f??, t?? p???t?ta t??
fa??t?? ?a? t?? pe?????sµ??? s?µat??? ?s??s? p??
??a µa?? e?????? t?? a??pt??? ?a???????? ?????.
S?µf??a µe t?? ???, se e???s? ?????a ta
pe??stat??? st?? a?apt?ss?µe?? ??sµ? ?a e??a?
t?sa p????, ?ste ?a e??a? ad??at? ?a
a?t?µet?p?st???, pa???? t? ße?t??s? t?? ?at?????
µ??a??µ?t?? ?a? t? ??????s? fa?µ???? ??a? ?e????.

?a??????a µe t?? a???s? t?? pe??stat???? t??
?a?????? a?apt?sseta? ?a? ? ?at???? te??????s?a,
?? p?a?t???? ???a???? d?????s?? ?a? ?? µ???d??
?e?ape?a?. ?????? ?µ?? st?? ?p??es?a t?? ?at?????
??e? te?e? ? p??????? f?s???, µe t? µ??f? t??
???s?? t?? ?ad?e????e?a?.

?e???? ?a?a?t???st??? pa?ade??µata
?a??a ???ta
F?t???a
F??t?sµ??a s?µat?d?a
??e?t????a-????t????a
?????a
?????a

??p?de? st? µ??? ?at? t?? ?a?????? d??e? µ?a
epa?astat??? µ???d?? p?? ßas??eta? se te??????
p?? s??d?????? t?? p??????? f?s??? µe t??
????????a
? a?t????e?ape?a µe s?????? ?et?????? ap?
????? (Boron
Neutron Capture Therapy - BNCT).

6
? p??????? a?t?d?as?

10B n ? a 7Li 2.31MeV ?(0.48MeV) 94
10B n ? a 7Li 2.79MeV 6

7
(No Transcript)
8
? e?e???? d?at?µ? t?? a?t?d?as?? e??a?
p??? ?????.
9

?a?????ta? Li ?a? He t?? ?p???? ? eµß??e?a st??
?st? e??a? 5µm ?a? 9µm a?t?st???a, d??ad? pe??p??
?s? ? d??µet??? e??? p????a ??tt???? ep?µ????,
??? ? e????e?a ape?e??e???eta? µ?sa st? ?a???????
??tta??, e?? ta ?e?t????? ??tta?a de? ß??pt??ta?.

10
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11
(No Transcript)
12
F??e?? t?? ??????

?pa?a?t?t? ? e?ap??es? µe????? a???µ?? at?µ??
ß????? 10 9 se ???e ?a??????? ??tta??.
??apat? ta ??tta?a ?a? a?t??a??st? d?µ??? t???
st???e??
?aµ??? t?????t?ta ?a? ep??e?t???? e?t?p?sµ?? st??
?a??????? pe????? t?? f???a.
??????a µe t?? ????
BSH?aµ?????
??PP?p??f?????

13
????? t?? ?et??????

????????? a?t?d?ast??e?
?p?ta???t???? d?at??e??

14
????????? ??t?d?ast??a?

Se a?t? t?? pe??pt?s? ta ?et????a e??a? p?????ta
s??s?? ßa???? p?????? ?p?? 235U ?a? 239Pu .

15
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16
(No Transcript)
17
?p?ta???t???? d?at??e??

?p?ta???t?? p??t?????ß?µßa?d?sµ?? p????e? ?p??
Li ?a? Be.
?eutron ?ubesß?µßa?d?sµ?? µeta?????? st???? p??
??e? p??s??f?s? de?te???? ? t??t??? µe d?sµ?
de?te????.
d d ? 3He n 3.27MeV
d t ? 4He n 17.59MeV

18
(No Transcript)
19
??s?

3.2 ??? 4.6 x 109 n /cm2 s

?????e?a
20 min
20
??s?µet??a

? p?s?t?ta ß????? p?? ????? ap????f?se? ta
?a??????? ??tta?a de? e??a? ded?µ???.
???sd?????eta? ?µµesa µ?s? t??
a????e?s?? t?? a?t???ß???a? ? p?? p????pte? ap?
t? ?et?????? s??????.

?a f?t???a p?? p????pt??? ap? ta ?e?µ???
?et????a p?? s???aµß????ta? ap? t? ß???? t??
de??µat?? s???????ta? ap? ??a? a????e?t? HPGe ?a?
a?a????ta? ??a ?a ?a????s??? t?? pe??e?t???t?ta
t?? de??µat?? se ß????.

22
?????e?t??

TEPC (Tissue-?quivalent gas Proportional
Counters)
TLD (ThermoLuminescent Detectors)

23
?e??pt?se?? efa?µ????

Glioblastoma (ep??et???? ?a?????? e??ef????)
?a????e? µe????µa (?a?????? t?? d??µat??)
?a????e?? ????? s?e??????? ad????
??p??? a?ept??µ???? ?a?????? p??st?t?

24
???t?a efa?µ????

??a ?????
??st???
?????
???t?
??te?
??s????

25
???e?a a??pt???? t?? µe??d??

1936 Locher ? eµp?e?st?? t?? ?d?a?
1938 University of Illinois p??te? µe??te?
1951 Brookhaven National Laboratory
1959 Massachusetts Institute of Technology
1968 Hatanaka (U.S.A) µe e??a????t???
ap?te??sµata

Berkeley University of California
??e???t??? ???t?a t?? ?ap???a?
??e???t??? ???t?a t?? S???d?a?
University of Essen in Netherlands
University of Pisa
?p?st?µ??e? se ??? t?? ??sµ?

27
??e??a

???es? ???? f????? ß????? D-CDU ? ?tlanta
Be?t??s? a????e?t???? d?at??e??
?fa?µ??? se ???a e?d? ?a????e??? p?e?µ??a,
pa????at??
???p???s? ?e???t??a? ?et??????
Berkeley
Birmingham
Texas
?ta??a
?ap???a

28
Stat?st??? - ?p?te??sµata

???e ????? 12.500 ?????p?? ??s??? st?? ??? ap?
Glioblastoma.
St? 8? d?e???? s???d??? ?NCT
201 as?e?e?? e??a? ??ße? t? ?e?ape?a
40 ap? a?t??? ?ta? ???ta??? µet? ap? 3 ?????a
10 ?ta? ???ta??? µet? ap? 10 ?????a
3 ?ta? ?e???te?a ap? p???
?a?e????e?e? pa??µ??e? µe e?e??e? t?? s?µßat????
a?t????e?ape?a?

29
??a?efa?a??s?

?NCT e??a? µ?a e?p?d?f???? µ???d?? ??a t?
?e?ape?a t?? ?a??????
?aµ?a t?????t?ta de? ??e? pa?at????e? st??
pe??aµat???? ???????? d???µ?? st? ??a ????? ?a?
t? ??st???
? a??pt??? t?? ?e???t???? ?et?????? ?a t?
?atast?se? d?a??s?µ? st? ep?ped? ??s???µe??? st?
e???? µ?????
? ??e??a s??e???eta? ?a? ap?te?e? a?a??a??t?ta
??a t?? ?atap???µ?s? a?t?? t?? as???e?a? p??
ap?te?e? p???? µ?st??a

On the optimal energy of epithermal neutron beams
for BNCT
Phys. Med. Biol. 45 (2000) 4958. Printed in
the UK
First Attempt of Boron Neutron Capture Therapy
for Hepatocellular Carcinoma
Japanese Journal of Clinical Oncology Advance
Access published June 19, 2007
Measurement and Calculation of Neutron and Gamma
Absorbed Dose in a Head Phantom in Boron Neutron
Capture Theory

University of Tehran- Iran
TWO MINIATURISED TEPCs IN A SINGLE DETECTOR FOR
BNCT MICRODOSIMETRY
Radiation Protection Dosimetry (2006), Vol.
122, No. 14, pp. 396400
APPLICATION OF DIFFERENT TL DETECTORS FOR THE
PHOTON DOSIMETRY IN MIXED RADIATION FIELDS USED
FOR BNCT
Radiation Protection Dosimetry (2006), Vol.
120, No. 14, pp. 8386
DOSIMETRY OF BNCT BEAMS WITH NOVEL
THERMOLUMINESCENT DETECTORS
Radiation Protection Dosimetry (2004), Vol.
110, Nos 1-4, pp. 623-626

??ß?????af?a
31

Performance of silicon microdosimetry detectors
in boron neutron capture therapy
University of Wollongong Australia
Brookhaven National Laboratory New York
The boronneutron capture agent D-CDU accumulates
preferentially in dividing brain tumor cells
Journal of Neuro-Oncology (2005) 74 275280