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Back

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Title: PowerPoint Author: Billgates Last modified by: wangbaoguo Created Date: 3/24/2004 8:29:55 AM Document presentation format: – PowerPoint PPT presentation

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Title: Back


1
?????
?????????????
???(?) ????(7)
???????
  1. ??
  2. ??

????
Back
2
?????
?????????????
3. ??
HLDA CD??? CD1?CD2CD339 CD??
3
?????
?????????????
?????CD??
1. T??
TCR
  • CD3 ITAM
  • CD4 MHC II
  • CD8 MHC I
  • CD2(LFA-2)
  • CD58(LFA-3)

T-APC
4
  • CD28 B7
  • CTLA-4 B7
  • (CD152)
  • CD40L CD40
  • (CD154)

?????
?????????????
5
?????
?????????????
6
?????
?????????????
2. B??
BCR
  • CD79a(Iga) ITAM
  • CD79b(Igß)
  • CD19 ???
  • CD21(CR2)
  • CD81
  • CD80(B7-1) APC-T
  • CD86(B7-2)
  • CD40 CD40L

7
?????
?????????????
8
?????
?????????????
3. ?????Fc??
9
?????
?????????????
10
????
?????
?????????????
????
1. ??
11
?????
?????????????
  • ?CD????
  • ???????

12
????
?????
?????????????
13
?????
?????????????
1. ?????
VLA-1 a1ß1 VLA-2 a2ß1 LFA-1 a1ß2
14
?????
?????????????
2. IGSF
CD4 CD8 MHC I MHC II
15
?????
?????????????
3. ?????
Selectin L P E
16
?????
?????????????
4. ????
cadherin
5. ?????? CD44
17
?????
?????????????
??????? CD4MHC II CD8MHC I
CD28B7 ICAMLFA-1
18
?????
?????????????
????
  • ??? CD4-MHC II
  • CD8-MHC I
  • 2. ???? CD28-B7
  • 3. ???????????

19
?????
?????????????
4. ??????(homing)
CD44 LFA-1
T
Homing receptor Addressin
MALT ???
20
?????
?????????????
  • ????
  • ????
  • CD4HIV
  • CD44????
  • ????
  • ??
  • CD4/CD8 AIDS?
  • ?????
  • CD3?? ?????????

21
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