Cardiac Physiology Electromechanical Function

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Cardiac PhysiologyElectromechanical Function

• Jim Pierce
• Bi 145a
• Lecture 11, 2009-10

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Early Insights intoMuscle Electrophysiology
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Early Insights intoCardiac Electrophysiology
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Cardiac Myocyte Action Potential
5
Cardiac Action Potentials
6
CardiacActionPotentials
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Conductance in the Myocyte
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Cardiac Myocyte Action Potential
9
Refractory Periods
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Myocyte Activiation Duringthe Relative
Refractory Period
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Sodium Channels
12
Electromechanical Coupling
13
Calcium Mediated Contraction
14
Contraction
15
Intercalated Disk
16
Gap Junctions
17
Cardiac Conduction System
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Automaticity
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Sinoatrial Node
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Automaticity andOverdrive Supression
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Cardiac Action Potentials
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Conductance in the Conduction system
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Cardiac Action Potentials
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Cycle Length
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Surface Electrode RecordingElectrocardiogram
(EKG)
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Contraction
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Contraction
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Contraction
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Contraction
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12 Lead EKG
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P - Wave Atrial Contraction
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A-V Insulation
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Electromechanical Coupling
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PR Interval AV Node Conduction
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QRS - Complex Ventricular Contraction
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Ventricular Contraction
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Ventricular Contraction
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Ventricular Contraction
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Depolarization - Repolarization
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Cardiac Cycle on the EKG
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Surface Electrode RecordingElectrocardiogram
(EKG)
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Concealed Conduction
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Concealed Conduction
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12 Lead EKG
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Limb Leads
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LimbLeads
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Bipolar Limb Leads
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Augmented Limb Leads
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Limb Leads
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Limb Leads
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Limb Leads
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Limb Leads
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Chest Leads
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Chest Leads
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Ventricular Contraction
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The QRS Vector Projection
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Electrical Axis
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Electrical Axis
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Electrical Axis
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Electrical Axis
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Electrical Axis
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Surface Electrode Recording
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Cardiac Action Potentials
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Electricity
65
Sinus Paced Rhythms
66
Rhythms Tachycardia
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Rhythms Fibrillation
68
Questions?