Drugs Acting on the Blood Systems

1
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• Drugs Acting on the Blood Systems

2
Antithrombotic Agents

• Anticoagulants
• ?? heparin , ??? coumarin
• Antiplatelet Agents
• aspirin
• ???? dipryridamole (Persantine)
• ???? ticlopidine (Ticlid)
• ??? hirudin
• ???? Abciximab
• Fibrinolytic agent
• ??? (streptokinase)
• ??? (urokinas)
• t-pA (tissue plasminogen activator )

3

• ????
• ????
• ???? VB12????
• ????????
• ?????? (EPO)
• ??? (GM-CSF)
• ????
• ?????
• IL-11
• TPO
• ????? ????

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???? Anticoagulants

• Introduction
• 1? Normal Blood Coagulation
• ???????? Fig

5
Coagulation cascade and sites of action of
anti-thrombotic agents.
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• 2? Anticoagulation
• 1) Fibrinolytic system
• 2) Clotting factor inhibitor AT-III