H1:????,????????????

1
???? ???????
??????
?????????????????????,????????????????????????
???????????????,????? ??????????????????,????,
?????????????????????????????,????????????????
2
????????????? H1????,????????????
H2??????,???????? H3????????????
3
??????
1.?? ????????H2??,???????,?????????
????AC,?CAMP??,????????H-K-ATP?(???),??H,??????
2.??? ????????????H1??,?????????,?????????
4
3.????? (1)??????H1-R,??????,??????,?????????????
A??V??,????,????? (2)?????????????????
???? ?????? 1. ???????? ???????????????????????,
??????? 2. ?????????????????(???????? ??? )?
5
????????
??H1 ?????
??????????,?H1?????????,??????,????????
6
???? ???H1 ?????????????(???)? ????(???)?
????(???)???????????,??????,??????????
???H1 ??????????(???)?????(???)?,??????????,?????
,??????
7
?????? ??H1???????????,23???????,????46?????
??????,????????????12???????,?????????,????1224?
????
8
??????
1. ???H1???? ?????????????????????????????????
?????????????,??????H2????????????H2???????????
9
2.?????? ? ????????????????,??????,????(???)????
???(????????)? ?????????????? ? ??????
???????H1??,??????????????????
3. ?? ?Ach???????????????????
10
??????
1. ??????? ????????????????????????????
?? ????????????????? ? ???????????????????
2.???? ???????????????,????????????????????? 3.
?????
11
??????
1. CNS???????????????????????????????????? 2.
????????????
????????? 1.?????????????????? 2.???????????/????
?,????????? 3.??????????? 4.???????????????????A
ST?ALT??,?????????
12
?? H1??????????
? ? ???? ???? ????? ??????(h)
????
46 ????
46 ???

46 ????
46 ????
46
????
gt24 ????
1224 ??? ???
68
????,????,???,???
13
??H2?????
????????????????????????????
?????? ?????,???????75,t1/2 ?2 h,????4
h????????????????????????
14
????(cimetidine)
???? 1.???????????????H2 ??,?????????????????M
-R?????????????????????????????????
15
2.????? ??????????????????????????????????????????
3. ??????????T????H2??,??????????? (HSF)
??,???????,????????????
16
?????? 1. ????????????????????,??????????????? 2.
???????(?-????,ZES)????? 3. ??????????????????????
?
17
??????
1. ?????????????? 2. CNS???????? 3.
???????????,?????? 4. ???????????????????????????
???????????????????????