Title: Pharmanex Workshop ReishiMax
1PharmanexWorkshopReishiMax
2Michael N. Chang, Ph.D.
- Chief Scientific Advisor
- Ph.D. in Organic Chemistry
- Post-doctoral Fellowship at MIT
- Over 20 years of pharmaceutical business
experience - 35 patents
3Josh Zhu, M.D., Ph.D.
- Director of Clinical Affairs Manager of
Clinical Pharmacology - Capital Institute of Medicine
- Ph.D. in Molecular and Cellular Physiology
- Member of six American medical societies
4Reishi and Immunity A Scientific Overview
Presented by Michael N. Chang, Ph.D.Chief
Scientific Advisor, Nu Skin Enterprises, Inc.
This material is provided for scientific and
educational purposes only and should not be
distributed or used in conjunction with the sale
or distribution of any dietary supplement product.
5The Human Immune System
- ...is a complicated network of cells, antibodies
and proteins that serves following three main
functions
1. Removes waste and harmful material, to ensure
the normal function of the body. 2. Defends
against pathogens - bacteria, fungi and
virus. 3. Kills and removes dead and altered
cells.
6The Human Immune System
- ......is delicately balanced by a very
sophisticated feedback regulation and control
system - Prolonged immune deficiency can lead to
infection, frequent sickness, lack of vigor and
energy and impaired metabolism. - On the other hand, chronic activation of immune
system can also lead to certain autoimmune
conditions such as arthritis, lupus, nephritis,
allergy, etc. - Â
7Immune Cells Recognize and Destroy Pathogens
and Altered Cells
Immune cell swallows foreign invader
Chemical message alerts immune system that an
invader is present
8- Cell Surface Antigen
- How does it work?
- Pathogens, such as bacteria, fungus, virus, have
carbohydrates protruding outside of its surface. - Altered cells also have carbohydrate antigens
protruding.
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10Reishi Mushroom
Reishi (Ganoderma lucidum) mushroom is a fungus
occurring as a shelf-like form on the sides of
trees and stumps in densely wooded mountains with
high humidity and low light.
The spores of Reishi have such tough outer husks
that germination is next to impossible, which
accounts for its rarity
11Reishi Growing Process
Zoom in of Reishi body
1
1. Reishi body 2. Basidiomycete produces
sporidium 3. Mycelium
2
3
Growth of Basidiomycete
12Types of Reishi
- There are 62 types of Reishi, of which six are
most common - RED BLACK
- BLUE WHITE
- YELLOW PURPLE
-
- RED Reishi is preferred because it can produce
the highest quality extract and has been subject
to the most scientific evaluation
13Cultivation of Reishi
- In 1971, Yukio Naoi, a researcher of the Kyoto
University in Japan, successfully developed the
artificial cultivation of Reishi, which resulted
in reproducible and consistent production of
Reishi.
14Compounds Identified in Reishi Mushrooms
15Reishi Spores
- These highly active substances are the essence of
Reishi - They are the reproductive cells that are released
at maturity - However, Reishi spores are protected by an
extremely hard shell which prevent us from
optimally absorbing the actives
16Traditional Use
- Reishi, also known as Lingzhi, is one of the most
valued herbal products in Traditional Chinese
Medicine (TCM) - Reishis earliest herbal remedies were recorded
between 206 B.C. - 8 A.D. - In Taiwan, families often give Reishi to their
aging grandparents
17Clinical Research Approach for Reishi
- The polysaccharides of Reishi can regulate our
immune system. - It is generally recognized that certain
polysaccharides cannot be absorbed by the human
body. - When our intestine senses the presence of
certain polysaccharides, receptors within our
body will create a series of signals which then
stimulate the body to carry out biological
actions that regulate the immune system.
18Research Findings
Reishi Mushroom Extracts
- Cell support
- Immune dysfunction-related diseases
- Liver protection
- Nervous system dysfunction
- Cardiovascular protection and blood sugar support
19Pre-Clinical Studies
- Animal and in vitro studies have shown that
Reishi extracts - Enhances activity of lymphocytes and natural
killer (NK) cells - Enhances activity of cytokines and macrophages
- Decreases histamine release from mast cells
Wang SY, et al. International Journal of Cancer
199770(6)699-705. Lu Z, Lin ZB. 1994
International Symposium on Ganoderma Research,
October 24-26, 1994, Beijing Medical University,
Beijing , China, Program and Abstracts, p. 82.
20Clinical Studies
- In clinical studies, Reishi extracts have been
shown to - Increase levels of T-cell counts, CD4/CD8 ratio,
cytokine IL-2, complement C3 and
immunoglobulin G - Lower levels of T-suppressor cell counts
- Improve vigor and appetite
- Shorten recovery time
Kupin, V. (1992). The 4th International Symposium
on Ganoderma lucidum, Hyatt Regency hotel, June
10, 1992, Seoul, Korea, Program and Abstracts,
pp. 36-39. Yang QY, Wang, M. M. (1996). 1996
Taipei International Ganoderma Research
Conference, Taipei International Convention
Center (TICC), August 15-15, 1996, Abstracts,
Special Lecture.
21Clinical Application for Reishi
- Reishi stimulates the immune systems ability to
recognize pathogens and altered cells - Reishi provides complementary therapy to promote
health and longevity - stimulates the formation of antibodies
- stimulates the ability of proliferation of
immune cells - modulates the function of T cells and NK cells
22Optimal Immune System Support
Presented by Josh Zhu, M.D., Ph.D.Director of
Clinical and Pharmacology Affairs, Pharmanex, LLC
This material is provided for scientific and
educational purposes only and should not be
distributed or used in conjunction with the sale
or distribution of any dietary supplement product.
23- Scientifically Proven
- Health Benefits
- Supports healthy immune system functions
- Stimulates proliferation of defensive immune
cells in your body, including T Cells, B Cells
NK cells
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
24- Use of the best Reishi species
- RED Reishi or Ganoderma lucidum
- Use of the best Reishi cultivation method
- solid tree trunk, organic cultivation for
120-200 days - Free of pesticides, free of heavy metals, and no
unwanted microbial contamination
25Use of Pharmanex proprietary manufacturing
process to extract active components from Reishi
26Cracked Reishi Spores
Reishi spores 100 Cracked spores
3000X magnification under an
electronic microscope
27- Proprietary Formula
- Contains 1 Reishi spores (100 cracked)
- Standardized to
- 6 Reishi triterpenes
- 13.5 Reishi polysaccharides
28ReishiMax Pre-Clinical Studies
- A recent comparative study demonstrated enhanced
immune functions by ReishiMax - Increased serum antibodies
- Stimulated proliferation of immune cells
- Modulation of the T cell functions
- Enhanced the NK cell functions
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
29Humoral and Cell-Mediated Immune
- Humoral immune
- Blocking and eliminating infectious agents via
humoral molecules, - such as Immunoglobulin G (IgG)
- Cell-mediated Immune
- Blocking and eliminating infectious agents via
immune cells, - such as T cells and NK cells
30ReishiMax enhances humoral immune functions
By Medical Institute at National Taiwan
University
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
31ReishiMax enhances cell-mediated immune
functions
By Medical Institute at National Taiwan
University
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
32Higher Amount of Actives
33Recent Publications
- ReishiMax GLp contains unique
- polysaccharides that are responsible
- for immuno-modulating activities
- Conducted by Pharmanex SAB member Chi-Huey Wong
at Academia Sinica in Taiwan - Published Wang YY, Wong CH, et al. Bioorganic
Medicinal Chemistry 2002101057-1062. - Three new active compounds (lanostanoids)
identified in Reishi - Conducted by Pharmanex Scientists - J. Chang,
M. Chang, and others. - Published Ma J, Ye Q, et al. Journal of Natural
Products 200265(1)72-75.
34Higher Solubility
By Pharmanex Research Center at Shanghai Medical
University
35Competitive Advantage
- 6S process
- Best natural Red Reishi species
- Organic cultivation
- Cracked spores
- Proprietary manufacturing technology
- Highest level of actives on the market
- Scientifically proven
36Recommended Usage
- Take twice daily with meals
- 1 capsule each time for health maintenance
- 2 capsules each time for immune modulation
- Safe and well tolerated at the recommended dosage
37Taken together, ReishiMax and Tegreen 97 provide
a comprehensive cellular health maintenance
program
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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