Pharmanex Workshop ReishiMax

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PharmanexWorkshopReishiMax
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Michael N. Chang, Ph.D.

• Chief Scientific Advisor
• Ph.D. in Organic Chemistry
• Post-doctoral Fellowship at MIT
• Over 20 years of pharmaceutical business
  experience
• 35 patents

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Josh Zhu, M.D., Ph.D.

• Director of Clinical Affairs Manager of
  Clinical Pharmacology
• Capital Institute of Medicine
• Ph.D. in Molecular and Cellular Physiology
• Member of six American medical societies

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Reishi and Immunity A Scientific Overview
Presented by Michael N. Chang, Ph.D.Chief
Scientific Advisor, Nu Skin Enterprises, Inc.
This material is provided for scientific and
educational purposes only and should not be
distributed or used in conjunction with the sale
or distribution of any dietary supplement product.
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The Human Immune System

• ...is a complicated network of cells, antibodies
  and proteins that serves following three main
  functions

1. Removes waste and harmful material, to ensure
the normal function of the body. 2. Defends
against pathogens - bacteria, fungi and
virus. 3. Kills and removes dead and altered
cells.
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The Human Immune System

• ......is delicately balanced by a very
  sophisticated feedback regulation and control
  system
• Prolonged immune deficiency can lead to
  infection, frequent sickness, lack of vigor and
  energy and impaired metabolism.
• On the other hand, chronic activation of immune
  system can also lead to certain autoimmune
  conditions such as arthritis, lupus, nephritis,
  allergy, etc.
•  

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Immune Cells Recognize and Destroy Pathogens
and Altered Cells
Immune cell swallows foreign invader
Chemical message alerts immune system that an
invader is present
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• Cell Surface Antigen
• How does it work?
• Pathogens, such as bacteria, fungus, virus, have
  carbohydrates protruding outside of its surface.
• Altered cells also have carbohydrate antigens
  protruding.

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Reishi Mushroom
Reishi (Ganoderma lucidum) mushroom is a fungus
occurring as a shelf-like form on the sides of
trees and stumps in densely wooded mountains with
high humidity and low light.
The spores of Reishi have such tough outer husks
that germination is next to impossible, which
accounts for its rarity
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Reishi Growing Process
Zoom in of Reishi body
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1. Reishi body 2. Basidiomycete produces
sporidium 3. Mycelium
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Growth of Basidiomycete
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Types of Reishi

• There are 62 types of Reishi, of which six are
  most common
• RED BLACK
• BLUE WHITE
• YELLOW PURPLE
• RED Reishi is preferred because it can produce
  the highest quality extract and has been subject
  to the most scientific evaluation

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Cultivation of Reishi

• In 1971, Yukio Naoi, a researcher of the Kyoto
  University in Japan, successfully developed the
  artificial cultivation of Reishi, which resulted
  in reproducible and consistent production of
  Reishi.

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Compounds Identified in Reishi Mushrooms
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Reishi Spores

• These highly active substances are the essence of
  Reishi
• They are the reproductive cells that are released
  at maturity
• However, Reishi spores are protected by an
  extremely hard shell which prevent us from
  optimally absorbing the actives

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Traditional Use

• Reishi, also known as Lingzhi, is one of the most
  valued herbal products in Traditional Chinese
  Medicine (TCM)
• Reishis earliest herbal remedies were recorded
  between 206 B.C. - 8 A.D.
• In Taiwan, families often give Reishi to their
  aging grandparents

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Clinical Research Approach for Reishi

• The polysaccharides of Reishi can regulate our
  immune system.
• It is generally recognized that certain
  polysaccharides cannot be absorbed by the human
  body.
• When our intestine senses the presence of
  certain polysaccharides, receptors within our
  body will create a series of signals which then
  stimulate the body to carry out biological
  actions that regulate the immune system.

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Research Findings
Reishi Mushroom Extracts

• Cell support
• Immune dysfunction-related diseases
• Liver protection
• Nervous system dysfunction
• Cardiovascular protection and blood sugar support

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Pre-Clinical Studies

• Animal and in vitro studies have shown that
  Reishi extracts
• Enhances activity of lymphocytes and natural
  killer (NK) cells
• Enhances activity of cytokines and macrophages
• Decreases histamine release from mast cells

Wang SY, et al. International Journal of Cancer
199770(6)699-705. Lu Z, Lin ZB. 1994
International Symposium on Ganoderma Research,
October 24-26, 1994, Beijing Medical University,
Beijing , China, Program and Abstracts, p. 82.
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Clinical Studies

• In clinical studies, Reishi extracts have been
  shown to
• Increase levels of T-cell counts, CD4/CD8 ratio,
  cytokine IL-2, complement C3 and
  immunoglobulin G
• Lower levels of T-suppressor cell counts
• Improve vigor and appetite
• Shorten recovery time

Kupin, V. (1992). The 4th International Symposium
on Ganoderma lucidum, Hyatt Regency hotel, June
10, 1992, Seoul, Korea, Program and Abstracts,
pp. 36-39. Yang QY, Wang, M. M. (1996). 1996
Taipei International Ganoderma Research
Conference, Taipei International Convention
Center (TICC), August 15-15, 1996, Abstracts,
Special Lecture.
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Clinical Application for Reishi

• Reishi stimulates the immune systems ability to
  recognize pathogens and altered cells
• Reishi provides complementary therapy to promote
  health and longevity
• stimulates the formation of antibodies
• stimulates the ability of proliferation of
  immune cells
• modulates the function of T cells and NK cells

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Optimal Immune System Support
Presented by Josh Zhu, M.D., Ph.D.Director of
Clinical and Pharmacology Affairs, Pharmanex, LLC
This material is provided for scientific and
educational purposes only and should not be
distributed or used in conjunction with the sale
or distribution of any dietary supplement product.
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• Scientifically Proven
• Health Benefits
• Supports healthy immune system functions
• Stimulates proliferation of defensive immune
  cells in your body, including T Cells, B Cells
  NK cells

These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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• Use of the best Reishi species
• RED Reishi or Ganoderma lucidum
• Use of the best Reishi cultivation method
• solid tree trunk, organic cultivation for
  120-200 days
• Free of pesticides, free of heavy metals, and no
  unwanted microbial contamination

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Use of Pharmanex proprietary manufacturing
process to extract active components from Reishi
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Cracked Reishi Spores
Reishi spores 100 Cracked spores
3000X magnification under an
electronic microscope
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• Proprietary Formula
• Contains 1 Reishi spores (100 cracked)
• Standardized to
• 6 Reishi triterpenes
• 13.5 Reishi polysaccharides

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ReishiMax Pre-Clinical Studies

• A recent comparative study demonstrated enhanced
  immune functions by ReishiMax
• Increased serum antibodies
• Stimulated proliferation of immune cells
• Modulation of the T cell functions
• Enhanced the NK cell functions

These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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Humoral and Cell-Mediated Immune

• Humoral immune
• Blocking and eliminating infectious agents via
  humoral molecules,
• such as Immunoglobulin G (IgG)
• Cell-mediated Immune
• Blocking and eliminating infectious agents via
  immune cells,
• such as T cells and NK cells

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ReishiMax enhances humoral immune functions
By Medical Institute at National Taiwan
University
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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ReishiMax enhances cell-mediated immune
functions
By Medical Institute at National Taiwan
University
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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Higher Amount of Actives
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Recent Publications

• ReishiMax GLp contains unique
• polysaccharides that are responsible
• for immuno-modulating activities
• Conducted by Pharmanex SAB member Chi-Huey Wong
  at Academia Sinica in Taiwan
• Published Wang YY, Wong CH, et al. Bioorganic
  Medicinal Chemistry 2002101057-1062.
• Three new active compounds (lanostanoids)
  identified in Reishi
• Conducted by Pharmanex Scientists - J. Chang,
  M. Chang, and others.
• Published Ma J, Ye Q, et al. Journal of Natural
  Products 200265(1)72-75.

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Higher Solubility
By Pharmanex Research Center at Shanghai Medical
University
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Competitive Advantage

• 6S process
• Best natural Red Reishi species
• Organic cultivation
• Cracked spores
• Proprietary manufacturing technology
• Highest level of actives on the market
• Scientifically proven

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Recommended Usage

• Take twice daily with meals
• 1 capsule each time for health maintenance
• 2 capsules each time for immune modulation
• Safe and well tolerated at the recommended dosage

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Taken together, ReishiMax and Tegreen 97 provide
a comprehensive cellular health maintenance
program
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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