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Title: Pharmanex Workshop ReishiMax


1
PharmanexWorkshopReishiMax
2
Michael N. Chang, Ph.D.
  • Chief Scientific Advisor
  • Ph.D. in Organic Chemistry
  • Post-doctoral Fellowship at MIT
  • Over 20 years of pharmaceutical business
    experience
  • 35 patents

3
Josh Zhu, M.D., Ph.D.
  • Director of Clinical Affairs Manager of
    Clinical Pharmacology
  • Capital Institute of Medicine
  • Ph.D. in Molecular and Cellular Physiology
  • Member of six American medical societies

4
Reishi and Immunity A Scientific Overview
Presented by Michael N. Chang, Ph.D.Chief
Scientific Advisor, Nu Skin Enterprises, Inc.
This material is provided for scientific and
educational purposes only and should not be
distributed or used in conjunction with the sale
or distribution of any dietary supplement product.
5
The Human Immune System
  • ...is a complicated network of cells, antibodies
    and proteins that serves following three main
    functions

1. Removes waste and harmful material, to ensure
the normal function of the body. 2. Defends
against pathogens - bacteria, fungi and
virus. 3. Kills and removes dead and altered
cells.
6
The Human Immune System
  • ......is delicately balanced by a very
    sophisticated feedback regulation and control
    system
  • Prolonged immune deficiency can lead to
    infection, frequent sickness, lack of vigor and
    energy and impaired metabolism.
  • On the other hand, chronic activation of immune
    system can also lead to certain autoimmune
    conditions such as arthritis, lupus, nephritis,
    allergy, etc.
  •  

7
Immune Cells Recognize and Destroy Pathogens
and Altered Cells
Immune cell swallows foreign invader
Chemical message alerts immune system that an
invader is present
8
  • Cell Surface Antigen
  • How does it work?
  • Pathogens, such as bacteria, fungus, virus, have
    carbohydrates protruding outside of its surface.
  • Altered cells also have carbohydrate antigens
    protruding.

9
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Reishi Mushroom
Reishi (Ganoderma lucidum) mushroom is a fungus
occurring as a shelf-like form on the sides of
trees and stumps in densely wooded mountains with
high humidity and low light.
The spores of Reishi have such tough outer husks
that germination is next to impossible, which
accounts for its rarity
11
Reishi Growing Process
Zoom in of Reishi body
1
1. Reishi body 2. Basidiomycete produces
sporidium 3. Mycelium
2
3
Growth of Basidiomycete
12
Types of Reishi
  • There are 62 types of Reishi, of which six are
    most common
  • RED BLACK
  • BLUE WHITE
  • YELLOW PURPLE
  • RED Reishi is preferred because it can produce
    the highest quality extract and has been subject
    to the most scientific evaluation

13
Cultivation of Reishi
  • In 1971, Yukio Naoi, a researcher of the Kyoto
    University in Japan, successfully developed the
    artificial cultivation of Reishi, which resulted
    in reproducible and consistent production of
    Reishi.

14
Compounds Identified in Reishi Mushrooms
15
Reishi Spores
  • These highly active substances are the essence of
    Reishi
  • They are the reproductive cells that are released
    at maturity
  • However, Reishi spores are protected by an
    extremely hard shell which prevent us from
    optimally absorbing the actives

16
Traditional Use
  • Reishi, also known as Lingzhi, is one of the most
    valued herbal products in Traditional Chinese
    Medicine (TCM)
  • Reishis earliest herbal remedies were recorded
    between 206 B.C. - 8 A.D.
  • In Taiwan, families often give Reishi to their
    aging grandparents

17
Clinical Research Approach for Reishi
  • The polysaccharides of Reishi can regulate our
    immune system.
  • It is generally recognized that certain
    polysaccharides cannot be absorbed by the human
    body.
  • When our intestine senses the presence of
    certain polysaccharides, receptors within our
    body will create a series of signals which then
    stimulate the body to carry out biological
    actions that regulate the immune system.

18
Research Findings
Reishi Mushroom Extracts
  • Cell support
  • Immune dysfunction-related diseases
  • Liver protection
  • Nervous system dysfunction
  • Cardiovascular protection and blood sugar support

19
Pre-Clinical Studies
  • Animal and in vitro studies have shown that
    Reishi extracts
  • Enhances activity of lymphocytes and natural
    killer (NK) cells
  • Enhances activity of cytokines and macrophages
  • Decreases histamine release from mast cells

Wang SY, et al. International Journal of Cancer
199770(6)699-705. Lu Z, Lin ZB. 1994
International Symposium on Ganoderma Research,
October 24-26, 1994, Beijing Medical University,
Beijing , China, Program and Abstracts, p. 82.
20
Clinical Studies
  • In clinical studies, Reishi extracts have been
    shown to
  • Increase levels of T-cell counts, CD4/CD8 ratio,
    cytokine IL-2, complement C3 and
    immunoglobulin G
  • Lower levels of T-suppressor cell counts
  • Improve vigor and appetite
  • Shorten recovery time

Kupin, V. (1992). The 4th International Symposium
on Ganoderma lucidum, Hyatt Regency hotel, June
10, 1992, Seoul, Korea, Program and Abstracts,
pp. 36-39. Yang QY, Wang, M. M. (1996). 1996
Taipei International Ganoderma Research
Conference, Taipei International Convention
Center (TICC), August 15-15, 1996, Abstracts,
Special Lecture.
21
Clinical Application for Reishi
  • Reishi stimulates the immune systems ability to
    recognize pathogens and altered cells
  • Reishi provides complementary therapy to promote
    health and longevity
  • stimulates the formation of antibodies
  • stimulates the ability of proliferation of
    immune cells
  • modulates the function of T cells and NK cells

22
Optimal Immune System Support
Presented by Josh Zhu, M.D., Ph.D.Director of
Clinical and Pharmacology Affairs, Pharmanex, LLC
This material is provided for scientific and
educational purposes only and should not be
distributed or used in conjunction with the sale
or distribution of any dietary supplement product.
23
  • Scientifically Proven
  • Health Benefits
  • Supports healthy immune system functions
  • Stimulates proliferation of defensive immune
    cells in your body, including T Cells, B Cells
    NK cells

These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
24
  • Use of the best Reishi species
  • RED Reishi or Ganoderma lucidum
  • Use of the best Reishi cultivation method
  • solid tree trunk, organic cultivation for
    120-200 days
  • Free of pesticides, free of heavy metals, and no
    unwanted microbial contamination

25
Use of Pharmanex proprietary manufacturing
process to extract active components from Reishi
26
Cracked Reishi Spores
Reishi spores 100 Cracked spores
3000X magnification under an
electronic microscope
27
  • Proprietary Formula
  • Contains 1 Reishi spores (100 cracked)
  • Standardized to
  • 6 Reishi triterpenes
  • 13.5 Reishi polysaccharides

28
ReishiMax Pre-Clinical Studies
  • A recent comparative study demonstrated enhanced
    immune functions by ReishiMax
  • Increased serum antibodies
  • Stimulated proliferation of immune cells
  • Modulation of the T cell functions
  • Enhanced the NK cell functions

These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
29
Humoral and Cell-Mediated Immune
  • Humoral immune
  • Blocking and eliminating infectious agents via
    humoral molecules,
  • such as Immunoglobulin G (IgG)
  • Cell-mediated Immune
  • Blocking and eliminating infectious agents via
    immune cells,
  • such as T cells and NK cells

30
ReishiMax enhances humoral immune functions
By Medical Institute at National Taiwan
University
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
31
ReishiMax enhances cell-mediated immune
functions
By Medical Institute at National Taiwan
University
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
32
Higher Amount of Actives
33
Recent Publications
  • ReishiMax GLp contains unique
  • polysaccharides that are responsible
  • for immuno-modulating activities
  • Conducted by Pharmanex SAB member Chi-Huey Wong
    at Academia Sinica in Taiwan
  • Published Wang YY, Wong CH, et al. Bioorganic
    Medicinal Chemistry 2002101057-1062.
  • Three new active compounds (lanostanoids)
    identified in Reishi
  • Conducted by Pharmanex Scientists - J. Chang,
    M. Chang, and others.
  • Published Ma J, Ye Q, et al. Journal of Natural
    Products 200265(1)72-75.

34
Higher Solubility
By Pharmanex Research Center at Shanghai Medical
University
35
Competitive Advantage
  • 6S process
  • Best natural Red Reishi species
  • Organic cultivation
  • Cracked spores
  • Proprietary manufacturing technology
  • Highest level of actives on the market
  • Scientifically proven

36
Recommended Usage
  • Take twice daily with meals
  • 1 capsule each time for health maintenance
  • 2 capsules each time for immune modulation
  • Safe and well tolerated at the recommended dosage

37
Taken together, ReishiMax and Tegreen 97 provide
a comprehensive cellular health maintenance
program
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
38
  • www.pharmanex.com
  • product information
  • powerpoint presentation (Whats New)
  • Pharmanex Information Packet
  • product fact sheet
  • frequently asked questions
  • Pharmanex Product Showcase
  • meet the experts
  • interactive computer product training
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