Title: actin
1(No Transcript)
2actin
3troponin
actin
4tropomyosin
troponin
actin
5tropomyosin
troponin
actin
6myosin binding site
tropomyosin
troponin
actin
7(No Transcript)
8Ca2
Ca2
Ca2
Ca2
9Ca2
Ca2
Ca2
Ca2
Calcium ions are released from the sarcolemma
after stimulation from the T system
10Ca2
Ca2
Ca2
Ca2
11Ca2
Ca2
Ca2
Ca2
the calcium ions bind to the troponin and changes
its shape
12Ca2
Ca2
Ca2
Ca2
the calcium ions bind to the troponin and changes
its shape
13Ca2
Ca2
Ca2
Ca2
14Ca2
Ca2
Ca2
Ca2
15Ca2
Ca2
Ca2
Ca2
the troponin displaces the tropomyosin and
exposes the myosin binding sites
16Ca2
Ca2
Ca2
Ca2
17Ca2
Ca2
Ca2
Ca2
18Ca2
Ca2
Ca2
Ca2
the bulbous heads of the myosin attach to the
binding sites on the actin filaments
19Ca2
Ca2
Ca2
Ca2
20Ca2
Ca2
Ca2
Ca2
21Ca2
Ca2
Ca2
Ca2
the myosin heads change position to achieve a
lower energy state and slide the actin filaments
past the stationary myosin
22Ca2
Ca2
Ca2
Ca2
23Ca2
Ca2
Ca2
Ca2
24Ca2
Ca2
Ca2
Ca2
ATP binds to the bulbous heads and causes it to
become detached
25Ca2
Ca2
Ca2
Ca2
ATP binds to the bulbous heads and causes it to
become detached
26Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
Ca2
Ca2
Ca2
hydrolysis of ATP provides the energy to
re-cock the heads
27Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
Ca2
Ca2
Ca2
hydrolysis of ATP provides the energy to
re-cock the heads
28Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
Ca2
Ca2
Ca2
29Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
Ca2
Ca2
Ca2
calcium ions are re-absorbed back into the T
system
30Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
calcium ions are re-absorbed back into the T
system
31Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
the troponin reverts to its normal shape and the
tropomyosin move back to block the myosin binding
sites
32Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
the troponin reverts to its normal shape and the
tropomyosin move back to block the myosin binding
sites
33Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
the troponin reverts to its normal shape and the
tropomyosin move back to block the myosin binding
sites
34Pi
A
Pi
Pi
Pi
Pi
A
Pi
Pi
A
Pi
Pi
Ca2
phosphocreatine regenerates ATP
35A
Pi
Pi
Pi
Pi
A
Pi
Pi
Pi
A
Pi
Pi
Ca2
phosphocreatine regenerates ATP
36A
Pi
Pi
Pi
A
Pi
Pi
Pi
A
Pi
Pi
Pi
Ca2
phosphocreatine regenerates ATP
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