Jetzt bekommen Sie Ihr Fett

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Jetzt bekommen Sie Ihr Fett

• Wer ist Dr. Barry Sears ?
• www.DrSears.com
• Welche Rolle spielt Fischöl in der
  Menschheitsgeschichte ?

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Fettsäuren

• Einfach-ungesättigte Fettsäuren
• ( flüssig bei Raumtemperatur wenige
  Doppelbindungen)
• Mehrfach-ungesättigte Fettsäuren
• ( flüssig im Kühlschrank viele
  Doppelbindungen)
• Gesättigte Fettsäuren
• ( fest bei Raumtemperatur )

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Eicosanoide

• Eicosa Zwanzig für 20 C-Atome in einer Reihe
• 1936 von Ulf van Euler entdeckt-
• Genannt Prostaglandine weil aus der Prostata
  isoliert
• Z.Zt. gt 100 verschiedene Eicosanoide bekannt
• 1982 Dr. J.R. Vane, Dr. Samuelsson und Dr.
  Bergstrom bekommen den Nobelpreis in Medizin für
  ihre Arbeiten über Eicosanoide

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Eicosanoide Eigenschaften

• Second messenger
• Rezeptoren für Eicosanoide in der Zellwand
• Bestimmen die Wirkung auf cAMP
• gute Eicosanoide cAMP
• schlechte Eicosanoide cAMP

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Die Eicosanoid Stoffwechselwege

Gamma Linolsäure

Linolsäure
(GLA)




182w6
183w6
Delta 6 Desaturase

18 Carbon, 3 Doppel
-
Eine Omega 6 -
-

bindungen, eine Omega 6
Gehemmt durch Alkoholüberschuss,Virus
Fettsäure



FS




Alphalinolsäure (ALA)
Schlechte

Elongase

Eicosanoide
(verlängert Carbonkette)

Aktiviert durch


Di
-
homo Gamma
Insulin

Arachidonsäure


Linolsäure


(AA)
Delta 5 Desaturase

(DGLA)

204w6

gehemmt durch

203w6


EicopentaeonsäureEPA,
COX

Glucagon
Gute Eicosanoide


COX (Cycloxygenase)

PGG1 PGH1 Effekte von PGE1


12
-
15 Lipoxygenase

PGE

2

5
-
Lipoxygenase

Unterdrückt Insulinfreisetzung

Erweitert Blutgefässe

Verhindert Thrombozytenverklumpung

Erhöht das menschliche Wachstumshormon

Erhöht die Lymphokinfreisetzung

Leukotriene


Hydroxylierte
Senkt Cholesterol
(LTB4)

Senkt Histamin

Fettsäuren

Reduziert Schmerz

Reduziert Entzündung

5 Hydroxyeicosa
-

Senkt Schlafbedürfnis

Tetranoide

Senkt Magensäure

(5
-
HETE, 5 HETE

Wirkt als Bronchodilatator

Lacton)
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Eicosanoide

• Schlechte Eicosanoide ( Arachidonsäure AA
  langkettige Omega 3 Fettsäure)
• Gute Eicosanoide
• ( Eicopentaeonsäure EPAlangkettige Omega 3
  Fettsäure)
• Ratio AA/EPA 1,5 3 ideal
• 10 es drohen chron. Erkrankungen
• 15 oder höher bei chron.
  Erkrankungen
• Triglyceride/HDL 1 ideal 2 gut

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Die Diät nach Dr. Barry Sears

• Die ausgewogene Protein- und Kohlehydratzufuhr
  bei jeder Mahlzeit
• Die Reduktion von Kalorien ohne Hungergefühl und
  Entsagung
• Zufuhr von Fischöl

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Insulin und Eicosanoide

• Insulin stimuliert die Cholesterolproduktion in
  der Leber
• Weniger Insulin weniger schlechte
  Eicosanoide weniger Cholesterol
• gute Eicosanoide senken den Insulinspiegel
• Wichtig die Kontrolle des Insulinspiegels

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Der Sears Teller
1/3 Proteine 2/3
Kohlehydrate 1 Teelöffel
einfach ungesättigtes Fett

• 
  

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Welche Proteine ? Welche Kohlehydrate ? Welches
Fett ?

• Protein Gut Fisch, Hähnchen,Truthahn,Schweinef
  leisch mit wenig Fett
• Kohlehydrate Gut Gemüse,
• Früchte,ausgesuchtes Getreide (Hafer, Gerste
  )
• Schlecht Stärke und das meiste Getreide
• ( Brot,Nudeln, Reis,Kartoffeln )
• Fett Gut Olivenöl, Avocados
• Schlecht Milch, Margarine, Sojaöl
  Sonnenblumenöl

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Fischöl - Dosierung

• Erhaltungstherapie 2,5 Gramm/Tag1 Teelöffel
  oder 4 Kapseln
• Verbesserung der Herz-Kreislaufsituation
• 2,5-5 Gramm/Tag1-2 Teelöffel oder 4-8
  Kapseln
• Verbesserung der Hirnleistung und Reduktion von
  Entzündung
• 5-10 Gramm/Tag2-3 Teelöffel oder 8-16
  Kapseln
• Zur Behandlung von neurologischen Erkrankungen
  10-25 Gramm/Tag ( 1-3 Eßlöffel )

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Qualität von Fischölprodukten

• Kriterien
• 1. Gesamtmenge an langkettigen Omega 3 Fettsäuren
  gt 60 aller Fettsäuren
• 2. Quecksilbergehalt lt 10 ppb
• 3. PCB lt 30 ppb
• 4. Dioxine lt 1 ppt

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Stiftung Warentest 8/05

• Aldi Lachsölkapseln 500 mg
• 120 Stück 3 Euro
• Dm/Das gesunde Plus Omega-3 Lachsöl 1000
• 60 Stück 3 Euro 95

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Omega-6 fatty acids cause prostate tumor cell
growth in culture potential new drug target
identified, as well August 1, 2005. A study
conducted at the San Francisco VA Medical Center
(SFVAMC) has demonstrated that omega-6 fatty
acids such as the fat found in corn oil promote
the growth of prostate tumor cells in the
laboratory. The study also identifies a
potential new molecular target for anti-tumor
drugs an enzyme known as cPLA2, which plays a
key role in the chain leading from omega-6 fatty
acids to prostate tumor cell growth. The study
was led by Millie Hughes-Fulford, PhD, director
of the Laboratory of Cell Growth at SFVAMC and
scientific advisor to the U.S. Undersecretary of
Health for the Department of Veterans Affairs. It
is being published in the September 2005 issue of
Carcinogenesis, and is currently available
online. Working with human prostate cancer cells
in tissue culture, Hughes-Fulford and her fellow
researchers identified for the first time a
direct chain of causation When introduced into
prostate tumor cells in culture, omega-6 fatty
acid causes the production of cPLA2, which then
causes the production of the enzyme COX2. In
turn, COX2 stimulates the release of PGE2, a
hormone-like molecule that promotes cell growth.
"What's important about this is that omega-6
fatty acids are found in corn oil and most of the
oils used in bakery goods," says Hughes-Fulford,
who is also an adjunct professor of medicine at
the University of California, San Francisco
(UCSF). "Which means that if you're eating a diet
high in omega-6 fatty acids, it's possible that
you're turning on this cancer cascade, which has
been shown to be a common denominator in the
growth of prostate, colorectal, and some breast
cancers." The study points out that 60 years ago
in the United States, the dietary ratio of
omega-6 to omega-3, a beneficial fatty acid, was
1 to 2. Today, the ratio is 25 to 1. Over that
same 60 years, the incidence of prostate cancer
in the U.S. has increased steadily.
Hughes-Fulford also found that flurbiprofen, a
non-steroidal anti-inflammatory drug commonly
prescribed for arthritis, blocked the production
of cPLA2 and broke the chain leading to cell
growth. This means, she says, that new drugs
might be developed that could specifically target
cPLA2 and prevent COX2 from being released.
"COX2 has been implicated in the growth of many
types of tumors," she notes. "So if you can find
a way to block that cascade in the tumor,
starting with cPLA2, you might have a new way of
modifying or slowing tumor growth."
Hughes-Fulford points out that cPLA2 inhibitors
would avoid the problems inherent in the class of
drugs known as COX2 inhibitors. These drugs have
been shown to be effective against tumor growth
as well as in treating the pain associated with
inflammatory conditions such as arthritis, but
have been implicated in increased risk of
cardiovascular problems in people who take them
regularly. "COX2 inhibitors also inhibit
prostacyclins, which are enzymes that are
beneficial to the heart, and cPLA2 inhibitors
would not affect those," she explains. In future
research, Hughes-Fulford will be looking at the
overall effect of different types of fatty acids
on different tumor types in cell lines as well as
human biopsies. She plans a study that will
correlate type of fatty acid with tumor stage and
grade in order to obtain a clearer picture of
specific effects of different fats on tumor
progression. Co-authors of the study were
Raymond R. Tjandrawinata, PhD, of UCSF, Chai-Fei
Li, BA, of SFVAMC, and Sina Sayyah, BA, of SFVAMC
and UCSF. The research was funded by awards from
the U.S. Department of Veterans Affairs and in
part by grants from the National Aeronautics and
Space Administration. Funding was administered by
the Northern California Institute for Research
and Education (NCIRE).  
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Conclusions In this prospective randomized
dietary intervention trial, a low-fat diet
resulted in changes in serum fatty acid levels
that impacted the growth of human LNCaP cancer
cells in a dish. Further studies are indicated
evaluating reducing linoleic acid intake and
increasing omega-3 fatty acid intake for prostate
cancer prevention and treatment. GROWTH
INHIBITORY EFFECTS OF A LOW-FAT DIET ON PROSTATE
CANCER CELLS IN VITRO RESULTS OF A PROSPECTIVE
RANDOMIZED DIETARY INTERVENTION TRIAL IN MEN WITH
PROSTATE CANCER William J Aronson, Los Angeles,
CA Stephen J Freedland, Baltimore, MD Francisco
Conde, Naoko Kobayashi, Pinchas Cohen, Tung Ngo,
Pak Leung, Susan Bowerman, Jenny Hong, Brandon
Varr, Patricia deMiranda, David Elashoff, John
Glaspy, Susanne Henning, David Heber, R James
Barnard, Los Angeles, CA. Abstract This page
reported by J. Strax, last updated May 18, 2005
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Supplements von Dr.Snuffy Myers